IP Library › Granted Patent US 12,246,078
Granted Patent B2
US 12,246,078 · App. 16/123,415 · Granted Mar 11, 2025

Oral care formulations and methods for use

Inventor: Gerald P. Curatola (New York, NY)
A61K8/35A61K8/23A61K8/347A61K8/355A61K8/67A61K8/671A61K8/673A61K8/676A61K8/678A61K8/97A61K8/9789A61K8/988A61Q11/00A61K2800/5922
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Quick Facts
Patent No.
US 12,246,078
App. No.
16/123,415
Granted
Mar 11, 2025
Kind
B2
Abstract

An oral care product comprising at least one of phytomenadione (vitamin K 1 ), menaquinone (vitamin K 2 ), vitamin C, selenium, ubiquinone (Coenzyme Q 10 ), Astragalus , Ginseng, Schisandra , adaptogenic herbs, cannabidiol, or the like. An oral care product directed toward rebalancing micro-bacterial homeostasis in the mouth, or establishing and maintaining a healthy oral microbiome.

Claims (35)

1. A method for using a toothpaste to promote a healthy oral microbiome, the method comprising:

providing a toothbrush for a user, wherein the toothbrush comprises a handle and a set of bristles opposite the handle;

selecting a toothpaste consisting of a base constituent and an operative constituent;

placing a portion of the toothpaste on the set of bristles of the toothbrush;

brushing the teeth of a user; and

producing a mouth slurry in the mouth of the user by the brushing,

wherein the operative constituent consists of an effective amount of menaquinone-7, an effective amount of ubiquinone, and an effective amount of vitamin D, and, optionally, one or more selected from the group consisting of cannabidiol, vitamin A, selenium, vitamin E, propolis, lignite, biotin, prebiotic fibers, menaquinone-4, cranberry extract, stevia extract, Echinacea, grape seed extracts, cranberry extract, tangerine oil, lemon oil, methyl sulfonyl methane, pycnogenol, refined or unrefined cocoa, homeopathic tissue salts, Astragalus, Gynostemma , acai, Ganoderma, Withania, Epimedium, Tribulus, Shisandra , ginseng, Centella , and Ocimum tenuiflorum , and

wherein the base constituent consists of one or more selected from the group consisting of calcium carbonate, silica, glycerine, and water.

2. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, and an effective amount of the cannabidiol.

3. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, an effective amount of the vitamin A, an effective amount of the selenium, and an effective amount of the vitamin E.

4. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, an effective amount of the propolis, an effective amount of the lignite, an effective amount of the biotin, and an effective amount of the prebiotic fibers.

5. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, and at least one selected from the group consisting of: the Astragalus , the Gynostemma , the acai, the Ganoderma , the Withania , the Epimedium , the Tribulus , the Shisandra , the ginseng, the Centella , and the Ocimum tenuiflorum.

6. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, and an effective amount of the menaquinone-4.

7. The method of claim 1 , wherein the operative constituent consists of the effective amount of menaquinone-7, the effective amount of ubiquinone, the effective amount of vitamin D, an effective amount of the cranberry extract, an effective amount of the Astragalus , and an effective amount of the Ocimum tenuiflorum.

8. The method of claim 1 , further comprising: swishing the mouth slurry within the mouth of the user; and spitting the mouth slurry from the mouth of the user.

9. A method for using a toothpaste to promote a healthy oral microbiome, the method comprising:

providing a toothbrush for a user, wherein the toothbrush comprises a handle and a set of bristles opposite the handle;

selecting a toothpaste that comprises a base constituent and an operative constituent;

placing a portion of the toothpaste on the set of bristles of the toothbrush;

brushing the teeth of a user;

producing a mouth slurry in the mouth of the user by the brushing;

swishing the mouth slurry within the mouth of the user; and

spitting the mouth slurry from the mouth of the user,

wherein the operative constituent consists of an effective amount of menaquinone-7, an effective amount of ubiquinone, and an effective amount of vitamin D, and

wherein the base constituent consists of one or more selected from the group consisting of calcium carbonate, silica, glycerine, and water.

10. A method for using a toothpaste to promote a healthy oral microbiome, the method comprising:

providing a toothbrush for a user, wherein the toothbrush comprises a handle and a set of bristles opposite the handle;

selecting a toothpaste that comprises a base constituent and an operative constituent;

placing a portion of the toothpaste on the set of bristles of the toothbrush;

brushing the teeth of a user;

producing a mouth slurry in the mouth of the user by the brushing;

swishing the mouth slurry within the mouth of the user; and

spitting the mouth slurry from the mouth of the user,

wherein the operative constituent consists of an effective amount of menaquinone-7, an effective amount of ubiquinone, an effective amount of vitamin D, and an effective amount of an Astragalus adaptogenic herb, and

wherein the base constituent consists of one or more selected from the group consisting of calcium carbonate, silica, glycerine, and water.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2026
From: CURATOLA, GERALD P.
To: REVITIN LIFE SCIENCES, LLC
Reel/Frame 075218/0122 →
Continuity (2)
Provisional Application 62558571 · Sep 14, 2017
Related Publication 20190076343A1 · Mar 14, 2019
References Cited (57)
US 3992519A · Hofmann · 1976 [cited by applicant]
US 4440745A · Schmidt · 1984 [cited by examiner]
US 6503483B2 · Shuch · 2003 [cited by applicant]
US 8506953B2 · Bottner · 2013 [cited by applicant]
US 8563053B2 · Mousa · 2013 [cited by examiner]
US 8728446B2 · Hurwitz · 2014 [cited by applicant]
US 9554986B2 · Harvey · 2017 [cited by applicant]
US 9987217B2 · Herrmann · 2018 [cited by examiner]
US 10172786B2 · Anastassov et al. · 2019 [cited by applicant]
US 20040067204A1 · Wolf · 2004 [cited by examiner]
US 20040258634A1 · Cazor et al. · 2004 [cited by applicant]
US 20060142184A1 · Bannister · 2006 [cited by applicant]
US 20090238774A1 · Connolly · 2009 [cited by applicant]
US 20120237456A1 · Trivedi · 2012 [cited by examiner]
CA 1237081A · 1988 [cited by applicant]
CN 104288082A · 2015 [cited by examiner]
CN 105434263A · 2016 [cited by applicant]
EP 0117321 · 1984 [cited by applicant]
EP 2815654 · 2014 [cited by applicant]
EP 2815654A1 · 2014 [cited by applicant]
JP S63179823A · 1988 [cited by applicant]
WO 2006060145A2 · 2006 [cited by applicant]
WO WO2012068730 · 2010 [cited by examiner]
WO 2014191009A1 · 2014 [cited by applicant]
WO 2015017625A1 · 2015 [cited by applicant]
WO WO2015017625 · 2015 [cited by applicant]
WO 2015099755A1 · 2015 [cited by applicant]
WO WO2016100516 · 2016 [cited by examiner]
Gordeladze et al., Vitamin K2: Vital for Health and Wellbeing, “Vitamin K2 and its impact on tooth epigenetics”, p. 27, Mar. 2017. [cited by examiner]
Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. Nov. 2004;134(11):3100-5. [cited by applicant]
Bostrom K, Watson KE, Horn S, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. Apr. 1993;91(4):1800-9. [cited by applicant]
Abedin M, Tintut Y, Demer LL. Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. Jul. 2004;24(7):1161-70. [cited by applicant]
Schurgers LJ, Dissel PE, Spronk HM, et al. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63, Abstract Only. [cited by applicant]
Iwamoto J, Takeda T, Sato Y. Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis. Nutr Rev. Dec. 2006;64(12):509-17. [cited by applicant]
Kaneki M, Hodges SJ, Hosoi T, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutritio… [cited by applicant]
Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res. Mar. 2000;15(3):515-21. [cited by applicant]
Iwamoto J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and bisphosphonate in postmenopausal women with osteoporosis. Yonsei Med J. Oct. 30, 2003;44(5):751-6. [cited by applicant]
Iwamoto J, Takeda T, Sato Y. Effects of vitamin K2 on osteoporosis. Curr Pharm Des. 2004;10(21):2557-76. [cited by applicant]
Schurgers LJ, Teunissen KJ, Knapen MH, et al. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Ar… [cited by applicant]
Luo G, Ducy P, McKee MD, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. Mar. 6, 1997;386(6620):78-81. [cited by applicant]
Wang Y, Zhang W, Zhang Y, et al. VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation. Mar. 28, 2006;113(12):1615-21. [cited by applicant]
Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF. Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2. Arch Intern Med. Jan. 23, 2006… [cited by applicant]
Schurgers LJ, Aebert H, Vermeer C, Bultmann B, Janzen J. Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood. Nov. 15, 2004;104(10):3231-2. [cited by applicant]
Habu D, Shiomi S, Tamori A, et al. Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. JAMA. Jul. 21, 2004;292(3):358-61. [cited by applicant]
Mizuta T, Ozaki I, Eguchi Y, et al. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer. Feb. 15… [cited by applicant]
Tsujioka T, Miura Y, Otsuki T, et al. The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica. May 2006;91(5):613-9. [cited by applicant]
Hojo K, Watanabe R, Mori T, Taketomo N. Quantitative measurement of tetrahydromenaquinone-9 in cheese fermented by propionibacteria. J Dairy Sci. Sep. 2007;90(9):4078-83. [cited by applicant]
Shoji S. Vitamin K and vascular calcification. Clin Calcium. Aug. 2002;12(8):1123-8. [cited by applicant]
Katsuyama H, Ideguchi S, Fukunaga M, et al. Promotion of bone formation by fermented soybean (natto) intake in premenopausal women. J Nutr Sci Vitaminol (Tokyo). Apr. 2004;50(2):114-20, Abstract Only. [cited by applicant]
Sconce E, Avery P, Wynne H, Kamali F. Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. Blood. Mar. 15, 2007;109(6):2419-23. [cited by applicant]
Database GNPD [Online] Mintel; Oct. 2012 (Oct. 2012), Calcium Bone Formula Dietary Supplement, XP002786551. [cited by applicant]
Database GNPD [Online] Mintel; Dec. 2015 (Dec. 2015), “Vitamin D Complex”, XP002786552. [cited by applicant]
Database GNPD [Online] Mintel; Jun. 2017 (Jun. 2017), “Calcium, Magnesium, and Vitamins D3 and K2 Supplement”, XP002786553. [cited by applicant]
Database GNPD [Online] Mintel; May 2017 (May 2017), “Vitamin K and D+ Calcium Based Food Supplement Gummies”, XP002786554. [cited by applicant]
Database GNPD [Online] Mintel; Jun. 2016 (Jun. 2016), “Dietary Supplement with Calcium, Magnesium and Vitamin K2”, XP002786555. [cited by applicant]
Database GNPD [Online] Mintel; May 2016 (May 2016), “Super K with Advanced K2 Complex”, XP002786556. [cited by applicant]
International Search Report for Application No. PCT/US2018/050485 mailed Nov. 30, 2018. 4 pgs. [cited by applicant]