IP Library › Granted Patent US 12,251,444
Granted Patent B2
US 12,251,444 · App. 18/102,123 · Granted Mar 18, 2025

Compositions and methods for delivering an agent to a wound

Inventors: Warren O. Haggard (Memphis, TN); Scott P. Noel (Memphis, TN); Joel D. Bumgardner (Memphis, TN)
Assignee: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
A61K47/36A61K9/7007A61K31/00A61K31/7036A61K38/14A61L15/28A61L15/44A61L27/20A61L27/58A61L29/043A61L29/146A61L29/148A61L29/16A61L31/042A61L31/146A61L31/148A61L31/16C08B37/003C08J5/18C08L5/08A61K9/0024A61L2300/232A61L2300/25A61L2300/406C08J2305/08
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,251,444
App. No.
18/102,123
Granted
Mar 18, 2025
Kind
B2
Abstract

The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

Claims (10)

1. A medical device for implantation comprising an acid-treated chitosan composition, prepared by a method comprising:

(a) dissolving chitosan in one or more acids in an aqueous solvent;

(b) forming the chitosan of step (a) into a film by pouring the chitosan into a thin layer and heating the chitosan to form a dehydrated chitosan film;

(c) lyophilizing the chitosan film under conditions that reduce the water content by about 10%-100%;

(d) neutralizing the chitosan film by contacting the film with water, a neutral, or a basic solution, wherein the water, neutral, or basic solution is selected to modulate a physical-mechanical property of the fiber;

(e) washing the chitosan film with water until neutral; and

(f) lyophilizing the film of step (e) to reduce the water content by about 80%-100%, thereby producing a biodegradable chitosan film.

2. The medical device of claim 1 , wherein the chitosan film adheres to the device.

3. The medical device of claim 1 , wherein the medical device comprises titanium or stainless steel.

4. The medical device of claim 1 , wherein the medical device is a prosthetic device.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 3, 2025
From: HAGGARD, WARREN O.; NOEL, SCOTT P.; BUMGARDNER, JOEL D.
To: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
Reel/Frame 069734/0409 →
Continuity (9)
Continuation 17027318 · Sep 21, 2020
Continuation 16050508 · Jul 31, 2018
Continuation 15483686 · Apr 10, 2017
Continuation 14618722 · Feb 10, 2015
Continuation 13256585
Provisional Application 61227606 · Jul 22, 2009
Provisional Application 61171805 · Apr 22, 2009
Provisional Application 61160539 · Mar 16, 2009
Related Publication 20230226190A1 · Jul 20, 2023
References Cited (79)
US 4895724A · Cardinal et al. · 1990 [cited by applicant]
US 5466462A · Rosenthal et al. · 1995 [cited by applicant]
US 5541233A · Roenigk · 1996 [cited by applicant]
US 5807295A · Hutcheon et al. · 1998 [cited by applicant]
US 5854382A · Loomis · 1998 [cited by applicant]
US 5958443A · Viegas et al. · 1999 [cited by applicant]
US 6162241A · Coury et al. · 2000 [cited by applicant]
US 6699287B2 · Son et al. · 2004 [cited by applicant]
US 6989157B2 · Gillis et al. · 2006 [cited by applicant]
US 7371403B2 · McCarthy et al. · 2008 [cited by applicant]
US 8303980B2 · Hirose et al. · 2012 [cited by applicant]
US 8993540B2 · Haggard · 2015 [cited by examiner]
US 9642948B2 · Haggard · 2017 [cited by examiner]
US 9662400B2 · Smith et al. · 2017 [cited by applicant]
US 10052388B2 · Haggard · 2018 [cited by examiner]
US 10799592B2 · Haggard et al. · 2020 [cited by applicant]
US 11576975B2 · Haggard et al. · 2023 [cited by applicant]
US 20030015825A1 · Sugie · 2003 [cited by examiner]
US 20030124172A1 · Lopez Lacomba · 2003 [cited by examiner]
US 20030206958A1 · Cattaneo et al. · 2003 [cited by applicant]
US 20060286156A1 · Hirose et al. · 2006 [cited by applicant]
US 20070059473A1 · Yamazaki et al. · 2007 [cited by applicant]
US 20070237811A1 · Scherr · 2007 [cited by applicant]
US 20090004276A1 · Ben-Shalom et al. · 2009 [cited by applicant]
US 20090075383A1 · Buschmann et al. · 2009 [cited by applicant]
US 20170258967A1 · Haggard et al. · 2017 [cited by applicant]
US 20190192666A1 · Haggard et al. · 2019 [cited by applicant]
US 20210113699A1 · Haggard et al. · 2021 [cited by applicant]
EP 1308177A1 · 2003 [cited by applicant]
JP H02268766A · 1990 [cited by applicant]
JP 2002526204A · 2002 [cited by applicant]
JP 2003511120A · 2003 [cited by applicant]
JP 2004231604A · 2004 [cited by applicant]
JP 2006516988A · 2006 [cited by applicant]
JP 2006347999A · 2006 [cited by applicant]
JP 2007526026A · 2007 [cited by applicant]
JP 2008110207A · 2008 [cited by applicant]
JP 2008161502A · 2008 [cited by applicant]
JP 2008527033A · 2008 [cited by applicant]
KR 20020017552 · 2002 [cited by examiner]
KR 20020017552A · 2002 [cited by applicant]
KR 2004090033A · 2004 [cited by examiner]
KR 20040090033A · 2004 [cited by applicant]
KR 20070118730A · 2007 [cited by applicant]
WO 1999043344A2 · 1999 [cited by applicant]
WO 2000016817A1 · 2000 [cited by applicant]
WO 2001025321A1 · 2001 [cited by applicant]
WO 2001041820A1 · 2001 [cited by applicant]
WO 2001057121A1 · 2001 [cited by applicant]
WO 2004069296A1 · 2004 [cited by applicant]
WO 2004078063A2 · 2004 [cited by applicant]
WO 2005062880A2 · 2005 [cited by applicant]
WO 2008157318A2 · 2008 [cited by applicant]
WO 2009056602A1 · 2009 [cited by applicant]
Muzzarelli et al., Carbohydrate Polymers, 2001, 45, 35-41. [cited by examiner]
Office Action dated Jun. 22, 2023 in corresponding European Patent Application No. 19170643.1 (3 pages). [cited by applicant]
Antonov et al., “Study of Wound Healing Properties of Chitosan,” Russian Agricultural Sciences, 2008, vol. 34, No. 6, pp. 426-427. [cited by applicant]
Bonferoni et al., “Chitosan Gels for the Vaginal Delivery of Lactic Acid: Relevance of Formulation Parameters to Mucoadhesion and Release Mechanisms,” AAPS PharmSciTech, 2006, vol. 7, No. 4, Article 104 <http://aapsphar… [cited by applicant]
Davies et al., “A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms,” Journal of Bacteriology, Mar. 2009, vol. 191, No. 5, pp. 1393-1403. [cited by applicant]
Kiang et al., “The Effect of the Degree of Chitosan Deacetylation of the Efficiency of Gene Transfection,” Biomaterials, 2004, vol. 25, pp. 5293-5301. [cited by applicant]
Merck Manual, 1992, pp. 183-189, 1460-1465. [cited by applicant]
Niekraszewicz, “Chitosan Medical Dressings,” Institute of Chemical Fibres, ul. M. Sklodowskiej-Curie 19/27, 90-570, Lödź, Poland, Fibres & Textiles in Eastern Europe, Jan./Dec. 2005, vol. 13, No. 6, p. 54. [cited by applicant]
Ohkawa et al., “Electrospinning of Chitosan,” Macromolecular Rapid Communications, 2004, vol. 25, No. 18, pp. 1600-1605. [cited by applicant]
Sangsanoh et al., “Stability Improvement of Electrospun Chitosan Nanofibrous Membranes in Neutral or Weak Basic Aqueous Solutions,” Biomacromolecules, 2006, vol. 7, No. 10, pp. 2710-2714. [cited by applicant]
Schiffman et al., “Cross-Linking Chitosan Nanofibers,” Biomacromolecules, 2007, vol. 8, No. 2, pp. 594-601. [cited by applicant]
Schiffman et al., “One-Step Electrospinning of Cross-Linked Chitosan Fibers,” Biomacromolecules, 2007, vol. 8, No. 9, pp. 2665-2667. [cited by applicant]
Bibliographic data: JP2004231604A: English abstract, dated Aug. 19, 2004 (1 page). [cited by applicant]
International Search Report mailed Nov. 2, 2010 in corresponding International PCT Patent Application No. PCT/US2010/027481. [cited by applicant]
European Search Report dated Aug. 6, 2013 in corresponding European Patent Application No. 10753982.7. [cited by applicant]
English translation of the Office Action mailed Jan. 7, 2015 in corresponding Japanese Patent Application No. 2012-500887. [cited by applicant]
English translation of the Decision of Rejection dated Dec. 11, 2015 in corresponding Japanese Patent Application No. 2012-500887. [cited by applicant]
English translation of the Decision of Dismissal of Amendment dated Dec. 11, 2015 in corresponding Japanese Patent Application No. 2012-500887. [cited by applicant]
Office Action dated Feb. 20, 2017 in corresponding Japanese Patent Application No. 2016-000051. [cited by applicant]
Office Action dated Mar. 10, 2017 in corresponding European Patent Application No. 10753982.7. [cited by applicant]
Decision of Rejection (with English translation) dated Sep. 5, 2017 in corresponding Japanese Patent Application No. 2016-000051. [cited by applicant]
Communication pursuant to Article 94(3) EPC dated Feb. 9, 2018 in corresponding European Patent Application No. 10753982.7. [cited by applicant]
Extended European Search Report mailed Nov. 26, 2019 in corresponding European Patent Application No. 19170643.1. [cited by applicant]
Yudanova et al., “Modern wound dressings: Manufacturing and properties,” Pharmaceutical Chemistry Journal, 2006, vol. 40, No. 2, pp. 85-92. [cited by applicant]
Office Action dated Mar. 1, 2024 in corresponding European Patent Application No. 19170643.1 (7 pages). [cited by applicant]