IP Library › Granted Patent US 12,281,359
Granted Patent B2
US 12,281,359 · App. 17/392,098 · Granted Apr 22, 2025

Variants of TNFSF15 and DCR3 associated with Crohn's disease

Inventor: Dermot P. McGovern (Los Angeles, CA)
Assignee: CEDARS-SINAI MEDICAL CENTER
C12Q1/6883C12Q2600/112C12Q2600/118C12Q2600/156C12Q2600/172
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Quick Facts
Patent No.
US 12,281,359
App. No.
17/392,098
Granted
Apr 22, 2025
Kind
B2
Abstract

Described herein are methods and compositions related to the discovery of associations in TNFSF15 15 and DcR3 genetic loci across in Caucasian, Puerto Rican, and Korean Crohn's Disease, as demonstrated via trans-ethnic fine mapping. The present invention provides methods of quantifying risk and diagnosing susceptibility to Crohn's disease in a subject by determining the presence of one or more risk variants are at the TNF SF15 (or TL1A) and/or DcR3 genetic loci.

Claims (5)

1. A method of treating an inflammatory bowel disease (IBD) in a subject in need thereof, the method comprising administering to the subject an anti-tumor necrosis factor-like cytokine 1A (anti-TL1A) antibody, provided that the subject comprises a polymorphism in TNFSF 15 at the position “N” within SEQ ID NO: 3, SEQ ID NO: 2, SEQ ID NO: 4, or a combination thereof, wherein the polymorphism within SEQ ID NO: 3is a “G” allele; the polymorphism within SEQ ID NO: 2 is an “A” allele; and the polymorphism within SEQ ID NO: 4 is a “T” allele.

2. The method of claim 1 , wherein the inflammatory bowel disease is Crohn's disease (CD).

3. The method of claim 1 , provided that the subject further comprises a polymorphism in TNFSF15 within rs4979462.

4. The method of claim 1 , provided that the subject is of Asian descent.

5. The method of claim 3 , wherein the polymorphism in TNFSF15within rs4979462 is a “T” allele.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 22, 2022
From: MCGOVERN, DERMOT P.
To: CEDARS-SINAI MEDICAL CENTER
Reel/Frame 059345/0565 →
Continuity (4)
Division 15946632 · Apr 5, 2018
Continuation 14890712
Provisional Application 61824932 · May 17, 2013
Related Publication 20210371931A1 · Dec 2, 2021
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