Granted Patent B2

US 12,285,539 · App. 17/233,101 · Granted Apr 29, 2025

Inventors: Lauren Lydecker (Millbury, MA); Poorva Rajguru (Shoreview, MN); David Wulfman (Minneapolis, MN); Joseph Rausa (Littleton, MA)

Assignee: Boston Scientific Scimed, Inc.

A61L26/0023A61L26/0076A61L26/0085C08K3/011C08K3/32C08L5/08A61L2400/04C08K2003/324

Abstract

Claims (18)

1. A method of preparing a composition, the method comprising:

electrospraying a solution consisting essentially of a chitosan salt through a needle into an aqueous solution comprising a crosslinking agent to produce a plurality of particles comprising chitosan and the crosslinking agent; and

freeze drying the plurality of particles;

wherein the solution has a viscosity at 25° C. ranging from about 1,500 cPs to about 8,000 cPs; wherein the crosslinking agent comprises tripolyphosphate; wherein the plurality of particles have an average diameter ranging from about 100 μm to about 750 μm and an average aspect ratio ranging from about 0.6 to 1.0; and wherein the plurality of particles has a porosity greater than 80%, as measured by mercury intrusion porosimetry.

2. The method of claim 1 , wherein the chitosan salt is chitosan acetate, chitosan lactate, chitosan succinate, chitosan glutamate, chitosan glycolate, or chitosan citrate.

3. The method of claim 1 , wherein the average diameter of the plurality of particles ranges from about 400 μm to about 600 μm.

4. The method of claim 1 , wherein the average aspect ratio of the plurality of particles ranges from about 0.8 to 1.0.

5. The method of claim 1 , wherein the plurality of particles has a steepness value ranging from about 30 to about 90.

6. The method of claim 1 , wherein the plurality of particles are substantially spherical in shape.

7. The method of claim 1 , wherein the plurality of particles have an average diameter ranging from about 300 μm to about 750 μm and a bulk density ranging from about 0.1 g/mL to about 0.7 g/mL.

8. The method of claim 1 , wherein the electrospraying includes applying a voltage of about 10 kV to about 30 KV to the needle.

9. The method of claim 1 , wherein the needle is a 23 gauge needle.

10. The method of claim 1 , wherein the solution comprises from about 0.5% to about 10% by weight chitosan, based on a volume of the solution.

11. A method of preparing a composition, the method comprising:

electrospraying a solution comprising a chitosan salt through a needle into an aqueous solution comprising a crosslinking agent to produce a plurality of particles consisting essentially of chitosan and the crosslinking agent; and

freeze drying the plurality of particles;

wherein the solution has a viscosity at 25° C. ranging from about 1,500 cPs to about 8,000 cPs; wherein the crosslinking agent comprises tripolyphosphate; wherein the plurality of particles have an average diameter ranging from about 300 μm to about 750 μm, an average aspect ratio ranging from about 0.6 to 1.0, and a bulk density ranging from about 0.1 g/ml to about 0.7 g/ml; and wherein the plurality of particles has a porosity greater than 80%, as measured by mercury intrusion porosimetry.

12. The method of claim 11 , wherein the composition is in the form of a powder.

Assignments (1)

Continuity (2)

References Cited (201)