Crystalline form a of 2, 2-bis(4-fluorophenyl)-2-phenylacetamide and preparation method therefor and application thereof
A crystalline form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide is provided. The crystalline form has good light stability, high temperature stability, and high humidity stability.
1. A crystal form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide, wherein the X-ray powder diffraction thereof using Cu-Kα radiation has characteristic peaks at 2θ diffraction angles of 10.4±0.2°, 11.8±0.2°, 18.8±0.2° and 21.3±0.2°.
2. The crystal form A of claim 1 , wherein the X-ray powder diffraction thereof using Cu-Kα radiation has further characteristic peaks at 2θ diffraction angles of 7.2±0.2°, and 20.8±0.2°.
3. The crystal form A of claim 2 , wherein the X-ray powder diffraction thereof using Cu-Kα radiation has further characteristic peaks at 2θ diffraction angles of 15.2±0.2°, 23.0±0.2°, and 25.7±0.2°.
4. The crystal form A of claim 3 , wherein the X-ray powder diffraction thereof using Cu-Kα radiation has further characteristic peaks at 2θ diffraction angles of 13.4±0.2°, 14.3±0.2°, 16.4±0.2°, 19.2±0.2°, 19.8±0.2°, 20.3±0.2°, and 24.1±0.2°.
5. The crystal form A of claim 4 , wherein the X-ray powder diffraction thereof using Cu-Kα radiation has further characteristic peaks at 2θ diffraction angles of 22.1±0.2°, 22.5±0.2°, 25.0±0.2°, 26.5±0.2°, 27.5±0.2°, 28.5±0.2°, 29.5±0.2°, 31.6±0.2°, and 32.6±0.2°.
6. The crystal form A of claim 1 , wherein the crystal form A has following characteristic peaks in X-ray powder diffraction pattern:
No. of
Peaks
2θ (°)
I %
1
10.44
48.4
2
11.779
48.1
3
13.381
24
4
14.299
32.1
5
15.22
38.1
6
18.76
100
7
19.24
47
8
19.78
57.3
9
20.28
52
10
20.84
69.3
11
21.339
80.1
12
22.96
40.4
13
24.08
32.7
14
25.699
48.5.
7. The crystal form A of claim 1 , wherein the crystal form A has following characteristic peaks in X-ray powder diffraction pattern:
No. of
Peaks
2-Theta
I %
1
7.163
6.4
2
10.44
48.4
3
11.779
48.1
4
13.381
24
5
14.299
32.1
6
15.22
38.1
7
16.401
7.4
8
18.76
100
9
19.24
47
10
19.78
57.3
11
20.28
52
12
20.84
69.3
13
21.339
80.1
14
22.96
40.4
15
24.08
32.7
16
24.962
12
17
25.699
48.5
18
26.5
11.1
19
27.54
8.4
20
28.46
25.9
21
29.517
15.8
22
31.58
36
23
32.599
18.
8. The crystal form A of claim 1 , wherein the crystal form A has an X-ray powder refraction pattern substantially as shown in FIG. 4 .
9. The crystal form A of claim 1 , wherein the crystal form A has a characteristic endothermic peak in a temperature range of 177.0° C.-191.0° C. measured by differential scanning calorimetry.
10. The crystal form A of claim 1 , wherein the crystal form A has a differential scanning calorimetry curve substantially as shown in FIG. 5 .
11. The crystal form A of claim 1 , wherein the crystal form A has a weight loss of 0.02584% before a temperature of 100° C. in its thermo gravimetric analysis curve.
12. The crystal form A of claim 1 , wherein the crystal form A has a thermo gravimetric analysis curve substantially as shown in FIG. 6 .
13. A method for preparing the crystal form A of claim 1 , comprising the following steps of:
dissolving 2,2-bis(4-fluorophenyl)-2-phenylacetamide by adding a good solvent thereto, evaporating the solvent or cooling to give a solid, and drying the solid to obtain the crystal form A.
14. The method of claim 13 , wherein said dissolving is performed by adding the good solvent at a temperature of 50° C. to 75° C., and said cooling is performed at a temperature of −18° C. to 5° C. to give a solid.
15. A method for preparing the crystal form A of claim 1 , comprising the following steps of:
dissolving 2,2-bis(4-fluorophenyl)-2-phenylacetamide by adding a good solvent thereto, then adding a poor solvent to obtain a solid, and drying the solid to obtain the crystal form A.
16. The method of claim 15 , wherein said dissolving is performed by adding the good solvent at a temperature of 15° C. to 35° C. and said adding a poor solvent is performed at a temperature of 15° C. to 35° C. to obtain a solid.
17. The method of claim 13 , wherein the good solvent is an organic solvent selected from the group consisting of a lower alcohol, a lower ketone, a lower ester, a lower nitrile, and a lower ether.
18. The method of claim 13 , wherein a ratio of 2,2-bis(4-fluorophenyl)-2-phenylacetamide to the good solvent is (10-40) mg: (0.1-5) mL.
19. The method of claim 15 , wherein the poor solvent is select from n-heptane, n-hexane, absolute ethyl ether, isopropyl ether or water.
20. A pharmaceutical composition, comprising the crystal form A of claim 1 and a pharmaceutically acceptable excipient.
21. A method for preventing or treating an inflammatory process or stroke, inhibition of cell potassium channel, reduction of erythrocyte dehydration, treatment or prevention of sickle cell disease, or enhancement of the resistance to degradation of a phenyl-containing potassium channel inhibitor in a biological medium, comprising administering a pharmaceutically effective amount of the crystal form A of claim 1 or a pharmaceutical composition comprising the same.
22. The method of claim 21 , wherein the inflammatory process is selected from the group consisting of multiple sclerosis, insulin-dependent diabetes mellitus, rheumatoid arthritis, peripheral neuritis, and pulmonary hypertension.
23. The method of claim 21 , wherein the medicament is administered orally, parenterally, intradermally, intrathecally, intramuscularly, subcutaneously, vaginally, as a buccal, sublingually, rectally, as a topical, inhalation, intranasal, or transdermally.
24. The method of claim 17 , wherein the lower alcohol is selected from the group consisting of methanol, ethanol, isopropanol and n-butanol, the lower ketone is acetone, the lower ester is ethyl acetate, the lower ether is tetrahydrofuran or dioxane, and the lower nitrile is acetonitrile.