IP Library › Granted Patent US 12,288,584
Granted Patent B2
US 12,288,584 · App. 17/214,664 · Granted Apr 29, 2025

Storage of information using mixtures of molecules

Inventors: George M. Whitesides (Newton, MA); Brian J. Cafferty (Cambridge, MA); Alexei S. Ten (Evanston, IL); Michael J. Fink (Cambridge, MA); Daniel J. Preston (Cambridge, MA); Milan M. Mrksich (Hinsdale, IL); Amit A. Nagarkar (Cambridge, MA)
Assignees: President and Fellows of Harvard College; Northwestern University
G11C13/02B82B1/008B82B3/0019B82B3/0047B82B3/009
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Quick Facts
Patent No.
US 12,288,584
App. No.
17/214,664
Granted
Apr 29, 2025
Kind
B2
Abstract

A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Claims (19)

1. A machine-readable medium comprising:

a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules,

wherein the molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position, and

further wherein each molecule in the collection is linked to the substrate at the respective addressable location.

2. The machine-readable medium of claim 1 , wherein each molecule of the set of unambiguously identifiable molecules is associated with a binary digit.

3. The machine-readable medium of claim 1 , wherein the numerical value has a radix and a predetermined number of positions.

4. The machine-readable medium of claim 3 , wherein the numerical value is a binary value having a predetermined number, N, of bits.

5. The machine-readable medium of claim 4 , wherein each collection encodes a bit string.

6. The machine-readable medium of claim 5 , wherein the bit string encodes an ASCII value.

7. The machine-readable medium of claim 1 , wherein each molecule in the set is identifiable by a physical property.

8. The machine-readable medium of claim 7 , wherein the physical property is a fluorescent emission wavelength.

9. The machine-readable medium of claim 8 , wherein each molecule in the set comprises a quantum dot.

10. The machine-readable medium of claim 9 , wherein at least one molecule in the set comprises lead sulfide, lead selenide, cadmium selenide, cadmium sulfide, cadmium telluride, indium arsenide, indium phosphide, zinc selenide, or zinc sulfide.

11. The machine-readable medium of claim 9 , wherein each molecule in the collection is linked to the substrate by an amide bond.

12. The machine-readable medium of claim 11 , wherein the substrate comprises an epoxy resin.

13. The machine-readable medium of claim 7 , wherein the physical property is a mass-to-charge ratio.

14. The machine-readable medium of claim 1 , wherein:

the numerical value is a binary value having 32 bits; and

the set of molecules comprises the oligopeptides represented by the following amino acid sequences: Ac-AK(me3)C, Ac-(abu)K(me3)C, Ac-VK(me3)C, Ac-GGK(me3)C (SEQ ID NO: 1), Ac-GVK(me3)C (SEQ ID NO: 2), Ac-GLK(me3)C (SEQ ID NO: 3), Ac-ALK(me3)C (SEQ ID NO: 4), Ac-GFK(me3)C (SEQ ID NO: 5), Ac-GVGK(me3)C (SEQ ID NO: 6), Ac-GLGK(me3)C (SEQ ID NO: 7), Ac-GAGGK(me3)C (SEQ ID NO: 8), Ac-GL (abu)K(me3)C (SEQ ID NO: 9), Ac-GFGK(me3)C (SEQ ID NO: 10), Ac-GRGK(me3)C (SEQ ID NO: 11), Ac-GPAGK(me3)C (SEQ ID NO: 12), Ac-AYGK(me3)C (SEQ ID NO: 13), Ac-GPFK(me3)C (SEQ ID NO: 14), Ac-GVVGK(me3)C (SEQ ID NO: 15), Ac-G(abu)FGK(me3)C (SEQ ID NO: 16), Ac-GVFGK(me3)C (SEQ ID NO: 17), Ac-GVYGK(me3)C (SEQ ID NO: 18), Ac-GARGGK(me3)C (SEQ ID NO: 19), Ac-GAVV (abu)K(me3)C (SEQ ID NO: 20), Ac-GFYGK(me3)C (SEQ ID NO: 21), Ac-GYYGK(me3)C (SEQ ID NO: 22), Ac-GYYAK(me3)C (SEQ ID NO: 23), Ac-GPYFK(me3)C (SEQ ID NO: 24), Ac-GRGFGK(me3)C (SEQ ID NO: 25), Ac-GYFGGK(me3)C (SEQ ID NO: 26), Ac-GYYGGK(me3)C (SEQ ID NO: 27), Ac-AYYGGK(me3)C (SEQ ID NO: 28), and Ac-GYY(abu)GK(me3)C (SEQ ID NO: 29), wherein each Ac is an acetyl and each Abu is a 2-aminobutyric acid.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 26, 2025
From: NAGARKAR, AMIT ARUN
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 070328/0949 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2025
From: MRKSICH, MILAN M.; TEN, ALEXEI S.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 070118/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2025
From: CAFFERTY, BRIAN JOSEPH; FINK, MICHAEL JOHANNES; PRESTON, DANIEL JOHN; WHITESIDES, GEORGE M.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 070119/0296 →
Continuity (4)
Continuation PCTUS2019053521 · Sep 27, 2019
Provisional Application 62846367 · May 10, 2019
Provisional Application 62738792 · Sep 28, 2018
Related Publication 20210217474A1 · Jul 15, 2021
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