Rollable bone implant for enclosing bone material
A bone implant for enclosing bone material is provided. The bone implant comprises a covering, which can be a biodegradable mesh. The covering is configured to be rolled into a diameter to at least partially enclose the bone material within the covering. In some embodiments, the covering includes a body portion and a closure portion adjacent to the body portion. The closure portion is configured to hold the covering in a rolled configuration to a predetermined diameter to at least partially enclose the bone material. A kit and a method of using the bone implant are also provided.
1. A bone implant for enclosing a bone material, the bone implant comprising a covering, the covering comprising a body portion and a closure portion adjacent to the body portion, the body portion comprising a surface and a first edge opposing a second edge across a longitudinal axis of the body portion, the first edge and the second edge configured to overlap on the surface to enclose the bone material in the body portion, the closure portion comprising a plurality of mesh threads, and a first edge opposing a second edge, the plurality of mesh threads disposed between the first edge of the closure portion and the second edge of the closure portion, the first edge of the closure portion joining the first edge of the body portion, the second edge of closure portion configured to overlap on the first edge of the closure portion such that the closure portion is configured to hold the body portion in a rolled configuration to a predetermined diameter, wherein the body portion comprises threads having a narrower regular pattern and the closure portion comprises threads having a wider regular pattern relative to the body portion such that the closure portion is more flexible than the body portion and more deformable than the body portion to wrap around and hold the body portion in the rolled configuration, wherein the body portion forms two opposing open ends at the first edge and the second edge configured to be pulled to have smaller diameters than a diameter of the surface in the rolled configuration, the rolled configuration being in a tubular conformation, and wherein the narrower regular pattern is a different pattern relative to the wider regular pattern such that the wider regular pattern has a larger porosity than a porosity of the narrower regular pattern allowing the bone material to be disposed in the body portion when the closure portion wraps around the body portion.
2. The bone implant of claim 1 , wherein the covering is biodegradable and comprises a mesh.
3. The bone implant of claim 1 , wherein the covering comprises a biodegradable mesh having shape memory to allow positioning from a planar configuration to a rolled configuration to at least partially enclose the bone material.
4. The bone implant of claim 2 , wherein the mesh comprises at least one or more of poly(lactide-co-glycolide) (PLGA), polylactide (PLA), polyglycolide (PGA), D-lactide, D,L-lactide, L-lactide, D,L-lactide-co-ε-caprolactone, L-lactide-co-ε-caprolactone, D,L-lactide-co-glycolide-co-ε-caprolactone, poly(D,L-lactide-co-caprolactone), poly(L-lactide-co-caprolactone), poly(D-lactide-co-caprolactone), poly(D,L-lactide), poly(D-lactide), poly(L-lactide), poly(esteramide), hydroxyapatite, calcium phosphate, ceramic or a combination thereof.
5. The bone implant of claim 2 , wherein the bone material is fully enclosed by the mesh and the mesh is porous to allow influx and efflux of cells.
6. The bone implant of claim 2 , wherein the mesh further comprises a polymer coating, the coating comprising a bioactive agent.
7. The bone implant of claim 6 , wherein the bioactive agent comprises an osteogenic or chondrogenic protein or peptide, demineralized bone matrix powder, a growth factor, an antibiotic, a drug or combinations thereof.
8. The bone implant of claim 2 , wherein (i) the mesh comprises an interior and an exterior, all or a portion of the interior and/or exterior comprising an adhesive material disposed thereon; or (ii) the mesh comprises an interior and an exterior, a portion of the interior and/or exterior having mating surfaces configured to hold the mesh in the rolled configuration.
9. The bone implant of claim 8 , wherein a first mating surface comprises projections or hooks and the second mating surface comprises matching voids for holding the mesh in the rolled configuration.
10. The bone implant of claim 8 , wherein (i) the adhesive material is water activated; (ii) the adhesive material is applied at the time of use; or (iii) the adhesive material comprises a volatile solvent which upon evaporation renders the mesh sticky to provide for self-adhesion.
11. The bone implant of claim 8 , wherein the interior or exterior of the mesh comprises a plurality of spaced apart indicia to aid in sizing of the covering for implantation.
12. A kit for making a bone implant, the kit comprising a covering, the covering comprising a body portion and a closure portion adjacent to the body portion, the body portion comprising a surface and a first edge opposing a second edge across a longitudinal axis of the body portion, the first edge and the second edge configured to overlap on the surface to enclose the bone material in the body portion, the closure portion comprising a plurality of mesh threads, and a first edge opposing a second edge, the plurality of mesh threads disposed between the first edge of the closure portion and the second edge of the closure portion, the first edge of the closure portion joining the first edge of the body portion, wherein the kit further comprises a sizing ring configured to be disposed around the second cylindrical body such that the sizing ring determines a diameter of the covering and is configured to hold the covering in a rolled configuration to a predetermined diameter, wherein the body portion comprises threads having a narrower regular pattern and the closure portion comprises threads having a wider regular pattern relative to the body portion such that the closure portion is more flexible than the body portion and more deformable than the body portion to wrap around and hold the body portion in the rolled configuration, wherein the body portion forms two opposing open ends at the first edge and the second edge configured to be pulled to have smaller diameters than a diameter formed by the surface in the rolled configuration, the rolled configuration being in a tubular conformation, and wherein the narrower regular pattern is a different pattern relative to the wider regular pattern such that the wider regular pattern has a larger porosity than a porosity of the narrower regular pattern allowing the bone material to be disposed in the body portion when the closure portion wraps around the body portion.
13. The kit of claim 12 , further comprising bone material which comprises demineralized bone matrix, allograft, xenograft, ceramic or a combination thereof.
14. The kit of claim 13 , further comprising a tray for holding the mesh to facilitate positioning of the bone material into the rolled configuration; and an adhesive.
15. The kit of claim 12 , wherein the covering is prepared by 3D printing.
16. A method of implanting a bone implant at a surgical site, the method comprising providing a bone implant according to claim 1 adding a bone material to the body portion of the bone implant, enclosing the bone material in the body portion by orientating the bone implant into a rolled configuration; and placing the rolled bone implant at the surgical site thereby implanting the bone implant at the surgical site.
17. The method of claim 16 , wherein the bone material is demineralized bone matrix, allograft bone, xenograft, ceramic, or a combination thereof.
18. The bone implant of claim 1 , wherein the covering further comprises a closure member adjacent to the body portion or the closure portion such that the closure member is configured to wrap around the body and the closure portion.