Modified zinc oxide nanocomposite, antibiotic composition comprising the same, and combination preparation with the same
View Patent ↗A zinc oxide nanocomposition is modified with a homobifunctional imidoester compound and an antibiotic composition contains the zinc oxide nanocomposition as an active ingredient. Also, a combination preparation contains the zinc oxide nanocomposite and an antifungal agent. The zinc oxide nanocomposite provides an antibiotic composition which is less toxic while exhibiting excellent antibiotic activity, for example, antiviral, antibacterial or antifungal activity. The antibiotic composition is usable to prevent contamination or infection by viruses, bacteria or fungi, inhibit the growth of viruses, bacteria or fungi, or treat infections by viruses, bacteria or fungi.
1. A modified zinc oxide nanocomposite comprising zinc oxide nanocrystals modified with a compound represented by the following Chemical Formula 1:
wherein, in Chemical Formula 1, X is (CH 2 ) n , and n is an integer from 5 to 10,
wherein the modified zinc oxide nanocomposite is prepared by mixing a salt of the compound represented by Chemical Formula 1 with the zinc oxide nanocrystals in a manner sufficient to provide for modified zinc oxide nanocrystals,
wherein the zinc oxide nanocrystals are crystals having a spindle shape.
2. The modified zinc oxide nanocomposite of claim 1 , wherein n is 5 or 6.
3. The modified zinc oxide nanocomposite of claim 1 , wherein the zinc oxide nanocrystals have a size of 100 to 300 nm.
4. The modified zinc oxide nanocomposite of claim 1 , wherein the modified zinc oxide nanocomposite exhibits a positive surface charge.
5. An antibiotic composition comprising the modified zinc oxide nanocomposite of claim 1 as an active ingredient.
6. The antibiotic composition of claim 5 , wherein the antibiotic composition has antiviral, antibacterial or antifungal activity.
7. The antibiotic composition of claim 6 , wherein the antibiotic composition has antibacterial activity against Gram-negative bacteria.
8. The antibiotic composition of claim 7 , wherein the antibiotic composition has antibacterial activity against Escherichia coli or Salmonella.
9. The antibiotic composition of claim 5 , wherein the antibiotic composition has antifungal activity against fungi of the genus Aspergillus.
10. The antibiotic composition of claim 5 , wherein the antibiotic composition further comprises an additional antifungal agent.
11. A method of preventing contamination or infection by viruses, bacteria or fungi, inhibiting the growth of viruses, bacteria or fungi, or treating infections by viruses, bacteria or fungi comprising administering the antibiotic composition of claim 5 to a subject.
12. The method of claim 11 , wherein the antibiotic composition is administered via injection.
13. An antifungal combination preparation containing the modified zinc oxide nanocomposite of claim 1 and an antifungal agent.
14. The antifungal combination preparation of claim 13 , wherein the antifungal agent is itraconazole or amphotericin B.
15. A method of preventing contamination or infection by viruses, bacteria or fungi, inhibiting the growth of viruses, bacteria or fungi, or treating infections by viruses, bacteria or fungi comprising administering the antibiotic composition of claim 10 to a subject.
16. The method of claim 15 , wherein the antibiotic composition is administered via injection.