Granted Patent B2

US 12,303,491 · App. 16/488,250 · Granted May 20, 2025

Inventors: David B. Lebo (Warminster, PA); Cong Li (Philadelphia, PA)

Assignee: Temple University-Of The Commonwealth System of Higher Education

A61K31/4174A61K9/0014A61K9/7061A61K47/10A61K47/20

Abstract

Claims (24)

1. A medicinal patch comprising:

a reservoir layer comprising a pharmaceutical composition comprising an imidazole class antifungal drug and a permeability enhancer; and

a skin adhesive layer comprising an acrylate;

wherein the reservoir layer or the skin adhesive layer further comprises polyvinylpyrrolidone;

wherein neither the reservoir layer nor the skin adhesive layer includes a disintegrant;

wherein the reservoir layer does not comprise a resinous crosslinking agent impregnated with the composition;

wherein the skin adhesive layer does not comprise an imidazole class antifungal drug; and

wherein the surface pH of the medicinal patch is between 4 and 6.

2. The medicinal patch of claim 1 , wherein the imidazole class antifungal drug is econazole nitrate.

3. The medicinal patch of claim 1 , wherein the permeability enhancer is thiourea.

4. The medicinal patch of claim 1 , wherein the reservoir layer or the skin adhesive layers further comprises propylene glycol.

5. The medicinal patch of claim 1 , wherein the reservoir layer or the skin adhesive layer further comprises a hydrophobic plasticizer.

6. The medicinal patch of claim 5 , wherein the hydrophobic plasticizer comprises triethyl citrate.

7. The medical patch of claim 1 , further comprising a backing membrane.

8. A method for treating a fungal infection in a subject, comprising administering to the subject the medicinal patch of claim 1 .

9. The method of claim 8 , wherein the fungal infection is a nail fungal infection.

10. The method of claim 8 , wherein the fungal infection is onychomycosis.

11. The method of claim 8 , wherein the fungal infection affects a portion of the subject' skin.

12. The method of claim 8 , wherein the fungal infection affects at least one of the subject's nail.

13. A medicinal patch comprising a drug-containing reservoir and skin contact adhesive, wherein the drug-containing reservoir and skin contact adhesive are separate and distinct layers;

wherein the reservoir layer consists of a) a pharmaceutical composition consisting of an imidazole class antifungal drug and optionally one or more excipients; b) a permeability enhancer; and c) polyvinylpyrrolidone;

wherein the skin adhesive layer consists of d) an acrylate;

wherein neither the reservoir layer nor the skin adhesive layer includes a disintegrant; and

wherein the surface pH of the medicinal patch is between 4 and 6.

Assignments (1)

Continuity (2)

References Cited (17)