Compounds and their use in therapy
The invention provides inter aliaa compound as defined herein and its use in the prevention or treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, e.g. cancer.
1. A compound which is: 4-(2-{2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy}ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide:
or
4-(2-{2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy}ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide:
or a pharmaceutically acceptable amide, carbamate or salt of any one thereof, including a salt of said amide or carbamate.
2. The compound as claimed in claim 1 , wherein the compound is 4-(2-{2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy}ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide:
or a pharmaceutically acceptable amide, carbamate or salt thereof, including a salt of said amide or carbamate.
3. A pharmaceutical composition comprising a compound as claimed in claim 1 , together with a pharmaceutically suitable carrier.
4. The composition as claimed in claim 3 , which also contains a further therapeutic agent.
5. A method of treating lymphoma or breast cancer in which inhibition of N-myristoyl transferase provides a therapeutic effect in a subject, comprising administering a therapeutically effective amount of a compound as claimed in claim 1 to the subject.
6. A kit of parts comprising: (a) a first pharmaceutical composition comprising a compound as claimed in claim 1 and a pharmaceutically acceptable carrier; and (b) a second pharmaceutical composition comprising a further therapeutic agent.
7. The compound as claimed in claim 1 , wherein the compound is 4-(2-{2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy}ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide:
or a pharmaceutically acceptable salt thereof.
8. A method of treating lymphoma or breast cancer in which inhibition of N-myristoyl transferase provides a therapeutic effect in a subject, comprising administering a therapeutically effective amount of a compound as claimed in claim 7 to the subject.
9. A pharmaceutical composition comprising a compound as claimed in claim 7 , together with a pharmaceutically suitable carrier.
10. The compound according to claim 1 , which is 4-(2-{2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy}ethyl)-N,1,5-trimethyl-1H-pyrazole-3-carboxamide):
or a pharmaceutically acceptable amide, carbamate or salt thereof, including a salt of said amide or carbamate.