Method for hydrolysis of lactic acid for aerosol delivery device
A method for preparing an aerosol precursor composition is provided, which includes the steps of providing a first aqueous solution comprising one or more organic acids in water; subjecting the first aqueous solution to hydrolysis to give a hydrolyzed aqueous solution with a higher organic acid monomer content on a dry weight basis than in the first aqueous solution; and combining the hydrolyzed aqueous solution with one or more aerosol formers to give an aerosol precursor composition. Typically, the aerosol precursor composition further contains nicotine. The disclosed method can lead to enhanced control over the composition and characteristics of the produced aerosol precursor composition.
1. A method for preparing an aerosol precursor composition, comprising:
providing a first aqueous solution comprising one or more organic acids in water;
subjecting the first aqueous solution to hydrolysis to give a hydrolyzed aqueous solution with a higher content of the one or more organic acids in monomer form on a dry weight basis than in the first aqueous solution; and
combining the hydrolyzed aqueous solution with one or more aerosol formers to give an aerosol precursor composition.
2. The method of claim 1 , further comprising adding nicotine to the hydrolyzed aqueous solution, the one or more aerosol formers, or a combination thereof to give the aerosol precursor composition.
3. The method of claim 2 , wherein the nicotine is tobacco-derived.
4. The method of claim 2 , wherein the nicotine is non-tobacco-derived.
5. The method of claim 1 , wherein the aqueous solution comprises, in addition to the one or more organic acids, reaction products of the organic acids.
6. The method of claim 1 , wherein the aqueous solution comprises, in addition to the one or more organic acids, one or more reaction products selected from the group consisting of acid dimers, acid trimers, acid oligomers, and acid polymers.
7. The method of claim 1 , wherein the one or more organic acids are selected from the group consisting of levulinic acid, succinic acid, lactic acid, pyruvic acid, benzoic acid, fumaric acid, and combinations thereof.
8. The method of claim 1 , wherein the one or more organic acids include lactic acid.
9. The method of claim 1 , wherein the hydrolysis comprises heating the first aqueous solution.
10. The method of claim 1 , wherein the first aqueous solution comprises at least about 10% by weight water.
11. The method of claim 1 , wherein the hydrolyzed aqueous solution contains at least about 85% of the organic acid by dry weight.
12. The method of claim 1 , wherein the hydrolyzed aqueous solution contains at least about 88% of the organic acid by dry weight.
13. The method of claim 1 , wherein the hydrolyzed aqueous solution contains at least about 90% of the organic acid by dry weight.
14. The method of claim 1 , wherein the hydrolyzed aqueous solution contains at least about 95% of the organic acid by dry weight.
15. The method of claim 1 , wherein the one or more aerosol formers comprise polyols.
16. The method of claim 1 , wherein the aerosol precursor composition has a pH less than about 8.
17. The method of claim 1 , further comprising adding additional components before, after, or during the combining step.
18. The method of claim 17 , wherein the additional components are flavorants.
19. The method of claim 1 , further comprising incorporating the aerosol precursor composition within a cartridge for an aerosol delivery device.