IP Library › Granted Patent US 12,329,412
Granted Patent B2
US 12,329,412 · App. 16/368,453 · Granted Jun 17, 2025

Systems for accessing nerves within bone

Inventors: Richard Pellegrino (Leesburg, VA); Samit Patel (Palo Alto, CA); Harold Carrison (Pleasanton, CA)
Assignee: Relievant Medsystems, Inc.
A61B17/3472A61B17/16A61B17/1642A61B17/1671A61B17/34A61B17/3403A61B17/3421A61B17/8819A61B18/14A61B18/148A61B18/1487A61B18/149A61B18/18A61B18/1815A61B18/20A61N7/00A61B2018/00011A61B2018/00017A61B2018/00339A61B2018/00434A61B2018/00577A61B18/0206A61B18/1492A61N2007/0026A61N2007/025
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Quick Facts
Patent No.
US 12,329,412
App. No.
16/368,453
Granted
Jun 17, 2025
Kind
B2
Abstract

System and methods are shown having a tube-within-tube assembly with a deployable curved deflectable tube or cannula that deploys from a straight cannula or trocar. The curved cannula has pre-curved distal end to create an angular range of 0° to 180° when fully deployed from the straight trocar. The curve is configured such that the flexible element carrying a treatment device can navigate through the angular range of deployment of the curved cannula. The curved cannula allows the flexible element to navigate through a curve within bone without veering off towards an unintended direction.

Claims (42)

1. A method for treating a basivertebral nerve in a vertebral body of a patient, the method comprising:

inserting an introducer having a handle coupled to a shaft defining a central channel and an opening at a distal tip through a pedicle of the vertebral body until the opening reaches the cancellous bone of the vertebral body;

delivering a cannula having a proximal end, a rotatable member, and a distal end through the central channel of the introducer, wherein the cannula distal end is deflectable relative to a central axis of the introducer;

advancing the cannula and a first stylet coupled with the cannula distal end further into the cancellous bone while rotating the rotatable member;

extending the cannula and the first stylet past the opening at the distal tip of the introducer to generate a curved path in the cancellous bone; and

via a treatment device coupled with the cannula distal end, delivering treatment to a treatment location proximate the basivertebral nerve.

2. The method of claim 1 , wherein inserting the introducer comprises:

inserting a second stylet into the introducer such that the second stylet extends beyond the opening of the introducer;

inserting the second stylet and the introducer simultaneously such that the second stylet pierces the bone as the introducer is being delivered through the pedicle.

3. The method of claim 1 , wherein delivering the cannula through the central channel comprises:

inserting a straightening stylet into a central passageway of the cannula, wherein the central passageway of the cannula is distinct from the central channel of the introducer; the straightening stylet comprising a rigid construction configured to straighten the cannula;

inserting the straightening stylet and the cannula simultaneously into the central channel of the introducer; and

removing the straightening stylet from the cannula.

4. The method of claim 3 :

wherein the straightening stylet further comprises a sharp distal end to pierce the cancellous bone;

wherein the sharp distal end extends beyond an opening at the distal tip of the cannula; and

wherein the straightening stylet and the cannula are installed simultaneously along with the introducer as the introducer is delivered into the cancellous bone.

5. The method of claim 1 , wherein extending the cannula past the opening at the distal tip of the introducer comprises:

inserting the first stylet into a central passageway of the cannula such that a distal tip of the first stylet extends to at least an opening at the distal tip of the cannula, wherein the central passageway of the cannula is distinct from the central channel of the introducer; and

simultaneously extending the cannula and the first stylet from the distal end of the introducer such that the first stylet blocks the open distal tip of the cannula while being delivered into the cancellous bone.

6. The method of claim 5 , further comprising removing the first stylet from the cannula.

7. The method of claim 1 further comprising delivering treatment sufficient to denervate at least a portion of the basivertebral nerve.

8. The method of claim 7 , wherein delivering the treatment comprises delivering focused, therapeutic heating to the basivertebral nerve.

9. The method of claim 7 , wherein delivering the treatment comprises delivering an agent to the treatment location.

10. The method of claim 7 , wherein delivering the treatment to the treatment location to denervate at least the portion of the basivertebral nerve comprises delivering radiofrequency energy.

11. The method of claim 7 , wherein delivering the treatment to the treatment location to denervate at least the portion of the basivertebral nerve comprises delivering ultrasonic energy.

12. A method for treating a basivertebral nerve in a vertebral body of a patient, the method comprising:

inserting an introducer through a cortical bone region of a pedicle and into a cancellous bone region of the vertebral body,

wherein the introducer has a central channel along its longitudinal axis and an axial opening at a distal tip of the introducer;

delivering a cannula having a proximal end, a rotatable member, and a distal end through the central channel of the introducer to the axial opening at the distal tip of the introducer, wherein the cannula distal end is deflectable relative to a central axis of the introducer;

advancing the cannula and a first stylet coupled with the cannula distal end further through the cortical bone region and into the cancellous bone region while rotating the rotatable member;

extending the cannula and the first stylet past the axial opening at the distal tip of the introducer to generate a curved path through a portion of the cancellous bone toward the basivertebral nerve,

via a treatment probe coupled with the cannula distal end and positioned proximate the basivertebral nerve, delivering treatment to the basivertebral nerve.

13. The method of claim 12 , wherein the treatment probe comprises a radiofrequency energy delivery probe.

14. The method of claim 12 , wherein the treatment probe comprises an ultrasonic energy delivery probe.

15. The method of claim 12 , further comprising treating the basivertebral nerve posterior to a basivertebral nerve junction.

16. The method of claim 12 , wherein the step of inserting the introducer through the cortical bone region of the pedicle and into the cancellous bone region of the vertebral body comprises:

inserting a second stylet into the introducer such that the second stylet extends beyond the axial opening of the introducer; and

inserting the second stylet and introducer simultaneously into the vertebral body such that the second stylet pierces cancellous bone within the cancellous bone region as the introducer is being delivered toward the basivertebral nerve.

17. The method of claim 12 , wherein the step of extending the cannula past the axial opening at the distal tip of the introducer comprises:

inserting the first stylet into a central passageway of the cannula such that a distal tip of the first stylet extends to at least an opening at the distal tip of the cannula, wherein the central passageway of the cannula is distinct from the central channel of the introducer; and

simultaneously extending the cannula and the first stylet from the distal end of the introducer such that the first stylet blocks the open distal tip of the cannula while being delivered into the vertebral body.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2019
From: PELLEGRINO, RICHARD; PATEL, SAMIT; CARRISON, HAROLD
To: RELIEVANT MEDSYSTEMS, INC.
Reel/Frame 049730/0556 →
Continuity (5)
Continuation 15040268 · Feb 10, 2016
Continuation 13862242 · Apr 12, 2013
Continuation 12566895 · Sep 25, 2009
Provisional Application 61100553 · Sep 26, 2008
Related Publication 20190282268A1 · Sep 19, 2019
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