IP Library › Granted Patent US 12,337,022
Granted Patent B2
US 12,337,022 · App. 18/576,171 · Granted Jun 24, 2025

Use of a vegetable extract from salvia haenkei as an active agent in the treatment of heart diseases

Inventors: Andrea Maria Giori (Lugano, CH); Andrea Alimonti (Lugano, CH)
Assignee: IBSA INSTITUT BIOCHIMIQUE SA
A61K36/537A61P9/00A61P9/04A61P9/06
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Quick Facts
Patent No.
US 12,337,022
App. No.
18/576,171
Granted
Jun 24, 2025
Kind
B2
Abstract

The present invention relates to the use of Salvia haenkei extract as an active agent in the treatment of heart diseases, being able to offer a significant contribution in slowing, relieving, reducing and/or preventing alterations and damages of the cardiac tissue. Furthermore, the present invention also relates to a pharmaceutical composition comprising Salvia haenkei extract and suitable pharmaceutically acceptable excipients, for use in the treatment of heart diseases.

Claims (12)

1. A method of improving, slowing, relieving and/or reducing heart disease in a subject in need thereof, said method comprising:

administering to a subject in need thereof a Salvia haenkei extract as an active agent, wherein said heart disease is at least one of: cardiac fibrosis, arrythmia, long QT syndrome (QTL), heart failure, heart attack and cardiotoxicity, wherein said heart disease is induced by drugs.

2. The method of claim 1 , wherein said heart disease is cardiac fibrosis.

3. The method of claim 1 , wherein said heart disease is cardiotoxicity.

4. The method of claim 1 , wherein said extract is to be administered via oral route.

5. The method of claim 1 , wherein said extract is to be administered in a dose of 1-5000 mg per day.

6. The method of claim 1 , wherein the Salvia haenkei extract is in the form of a pharmaceutical composition further comprising pharmaceutically acceptable vehicles.

7. The method of claim 6 , wherein said pharmaceutical composition is in the form of tablets, capsules, lozenges, orodispersible films, soft gelatin capsules, granulates or powder, orodispersible powder, liquid solutions, dressing, suspensions, or a combination thereof.

8. The method of claim 1 , wherein the Salvia haenkei extract is in the form of a food supplement.

9. The method of claim 6 , wherein the pharmaceutical composition comprises Salvia haenkei extract in a concentration of 0.1-500 mg/ml when in liquid form, or of 0.1-500 mg/mg when in solid form, of the composition.

10. The method of claim 6 , wherein the pharmaceutical composition comprises Salvia haenkei extract in a concentration of 0.1-500 mg/ml when in liquid form, or of 0.1-500 mg/mg when in solid form, of the supplement.

11. The method of claim 1 , wherein the drugs are chemotherapy drugs.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2025
From: ALTERGON SA
To: IBSA INSTITUT BIOCHIMIQUE SA
Reel/Frame 071174/0633 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2024
From: GIORI, ANDREA MARIA; ALIMONTI, ANDREA
To: ALTERGON SA
Reel/Frame 066209/0879 →
Priority Claims (1)
IT 102021000017666 · Jul 5, 2021 · national
Continuity (1)
Related Publication 20240261357A1 · Aug 8, 2024
References Cited (5)
EP 2762131A1 · 2014 [cited by examiner]
WO WO2019121427A1 · 2019 [cited by examiner]
Matic I et al., “Identification of <i>Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay”, Aging, vol. 8, No. 12, Dec. 28, 2016, pp. 3223-3240 .</i>. [cited by applicant]
Search Report and Written Opinion of PCT/EP2022/068287 issued Sep. 28, 2022. [cited by applicant]
Topcu G, “Bioactive triterpenoids from salvia species”, Journal of Natural Products, vol. 69, No. 3, Mar. 9, 2006, pp. 482-487. [cited by applicant]