IP Library Granted Patent US 12,340,875
Granted Patent B2
US 12,340,875 · App. 18/188,696 · Granted Jun 24, 2025

Systems and methods for automated monitoring and replenishment of genetic material reserves

Inventors: Robin Y. Smith (Boston, MA); Sunil Anant Gupta (Boston, MA)
Assignee: Sapphiros Laboratories LLC
G16B50/30G01N1/02G01N2001/028
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,340,875
App. No.
18/188,696
Granted
Jun 24, 2025
Kind
B2
Abstract

A meter value that reflects the amount of genetic material stored in a reserve is stored in a database for each reserve in a bank. Meter values allow a user to track the amount of genetic material in the reserves of a bank without needing to physically measure or disturb the reserves unnecessarily. As users withdraw and deposit genetic material from and into a reserve, the meter value is changed to reflect the change in the amount of genetic material in the reserve. In certain embodiments, the use of meter values enables accurate and instant accounting of a large number of reserves of genetic material for a large number of individuals. Users and/or individuals may be notified when a meter value falls below a threshold. Notifications may prompt a user to generate additional genetic material from biological sample or an individual to provide additional biological sample.

Claims (45)

1. A method, comprising:

updating, by a processor of a computing device, a meter value reflecting an amount of genetic material stored in a reserve of genetic material extracted from a biological sample of an individual based on each of one or more withdrawals or deposits of genetic material; and

determining, by the processor, whether the meter value is below a minimum threshold of an amount of genetic material to be maintained in the reserve.

2. The method of claim 1 , further comprising:

responsive to determining that the meter value is below the minimum threshold for the reserve, triggering, by the processor, a notification.

3. The method of claim 2 , wherein the triggering of the notification comprises issuing an alert of low reserve amount.

4. The method of claim 2 , wherein triggering the notification comprises automatically issuing, by the processor, a request to supply the individual associated with the reserve with a kit for providing a replenishment biological sample.

5. The method of claim 4 , wherein the kit comprises one or more instruments for collection of the replenishment biological sample from the individual associated with the reserve.

6. The method of claim 5 , wherein the one or more instruments includes one or more cheek (buccal) swabs.

7. The method of claim 1 , further comprising, responsive to determining that the meter value is below the minimum threshold for the reserve, replenishing the reserve with additional genetic material extracted from the biological sample from the individual associated with the reserve.

8. The method of claim 7 , wherein the additional genetic material is extracted from induced pluripotent stem cells generated from adult cells from the individual associated with the reserve.

9. The method of claim 1 , comprising, initially:

receiving, by the processor, an initial value reflecting an amount of genetic material initially present in the reserve of genetic material associated with the individual; and

storing, by the processor, the initial value as the meter value.

10. The method of claim 9 , wherein the initial value is based on an amount of genetic material extracted from a corresponding biological sample from the individual associated with the reserve and deposited in the reserve.

11. The method of claim 1 , comprising, for each of the one or more withdrawals of genetic material:

receiving, by the processor, a usage value that reflects an amount of genetic material removed in the withdrawal; and

updating, by the processor, the meter value for the reserve using the usage value.

12. The method of claim 1 , further comprising:

storing, by the processor, the meter value reflecting the amount of genetic material stored in the reserve.

13. A system, comprising:

a processor; and

a non-transitory computer readable memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to:

update, by the processor, a meter value reflecting an amount of genetic material stored in a reserve of genetic material extracted from a biological sample of an individual based on each of one or more withdrawals or deposits of genetic material; and

determine, by the processor, whether the meter value is below a minimum threshold of an amount of genetic material to be maintained in the reserve.

14. The system of claim 13 , wherein the instructions, when executed by the processor, cause the processor to:

responsive to determining that the meter value is below the minimum threshold for the reserve, trigger, by the processor, a notification.

15. The system of claim 14 , wherein the instructions, when executed by the processor, cause the processor to:

when triggering the notification, issue an alert of low reserve amount.

16. The system of claim 14 , wherein the instructions, when executed by the processor, cause the processor to:

when triggering the notification, automatically issue, by the processor, a request to supply the individual associated with the reserve with a kit for providing a replenishment biological sample.

17. The system of claim 16 , wherein the kit comprises one or more instruments for collection of the replenishment biological sample from the individual associated with the reserve.

18. The system of claim 17 , wherein the one or more instruments includes one or more cheek (buccal) swabs.

19. The system of claim 13 , wherein the instructions, when executed by the processor, cause the processor to, initially:

receive, by the processor, an initial value reflecting an amount of genetic material initially present in the reserve of genetic material associated with the individual; and

store, by the processor, the initial value as the meter value.

20. The system of claim 19 , wherein the initial value is based on an amount of genetic material extracted from a corresponding biological sample from the individual associated with the reserve and deposited in the reserve.

21. The system of claim 13 , wherein the instructions, when executed by the processor, cause the processor to, for each of the one or more withdrawals of genetic material:

receive, by the processor, a usage value that reflects an amount of genetic material removed in the withdrawal; and

update, by the processor, the meter value for the reserve using the usage value.

22. The system of claim 13 , wherein the instructions, when executed by the processor, cause the processor to:

store, by the processor, the meter value reflecting the amount of genetic material stored in the reserve.

23. A computer program product, comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to perform a method comprising:

updating, by the processor, a meter value reflecting an amount of genetic material stored in a reserve of genetic material extracted from a biological sample of an individual based on each of one or more withdrawals or deposits of genetic material; and

determining, by the processor, whether the meter value is below a minimum threshold of an amount of genetic material to be maintained in the reserve.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2025
From: SEAPORT DIAGNOSTICS, INC.
To: SAPPHIROS LABORATORIES LLC
Reel/Frame 070048/0113 →
CHANGE OF NAME Recorded Jan 29, 2025
From: ORIG3N, INC.
To: SEAPORT DIAGNOSTICS, INC.
Reel/Frame 070053/0990 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2025
From: SMITH, ROBIN Y.; GUPTA, SUNIL ANANT
To: ORIG3N, INC.
Reel/Frame 070054/0001 →
Continuity (4)
Continuation 16482945
Provisional Application 62584603 · Nov 10, 2017
Provisional Application 62453481 · Feb 1, 2017
Related Publication 20240062852A1 · Feb 22, 2024
References Cited (12)
US 11615866B2 · Smith et al. · 2023 [cited by applicant]
US 20110017733A1 · Polettini · 2011 [cited by examiner]
US 20140304012A1 · Marom · 2014 [cited by examiner]
US 20150193581A1 · Kaminski · 2015 [cited by examiner]
US 20180173842A1 · Smith · 2018 [cited by examiner]
US 20180246089A1 · Chou · 2018 [cited by examiner]
US 20190355441A1 · Smith · 2019 [cited by examiner]
US 20190362531A1 · Smith et al. · 2019 [cited by applicant]
EP 3315594A1 · 2018 [cited by applicant]
WO WO2018144691A1 · 2018 [cited by applicant]
International Preliminary Report on Patentability for International Application No. PCT/US2018/016377 mailed Aug. 6, 2019. [cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/US2018/016377 dated Apr. 26, 2018. [cited by applicant]