IP Library › Granted Patent US 12,343,366
Granted Patent B2
US 12,343,366 · App. 17/519,595 · Granted Jul 1, 2025

Prebiotic composition and method for improving intestinal health using the same

Inventors: Yung-Hsiang Lin (Taipei, TW); Chu-Han Huang (Taipei, TW)
Assignee: TCI CO., LTD.
A61K36/185A61K31/702A61K31/718A61P1/14A61P3/04
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Quick Facts
Patent No.
US 12,343,366
App. No.
17/519,595
Granted
Jul 1, 2025
Kind
B2
Abstract

Provided is a prebiotic composition, including a kiwifruit fermented product, inulin, and fructooligosaccharide, where the weight ratio of the kiwifruit fermented product, the inulin, and the fructooligosaccharide is 3-4:2.5-4:2.5-4. A method for improving intestinal health of a subject in need thereof by using the prebiotic composition is also provided.

Claims (17)

1. A method for promoting growth of Parabacteroides goldsteinii in a subject in need thereof, comprising administering an effective dose of a prebiotic composition to the subject, wherein the prebiotic composition consisting of a kiwifruit fermented product, inulin, and fructooligosaccharide,

wherein a weight ratio of the kiwifruit fermented product, the inulin, and the fructooligosaccharide is 3-4:2.5-4:2.5-4,

wherein the kiwifruit is Actinidia deliciosa , and

wherein the kiwifruit fermented product is obtained by the steps of: fermenting Actinidia deliciosa with 0.1% Saccharomyces cerevisiae for 1 day at 30° C. to obtain an initial fermentation broth, and fermenting the initial fermentation broth with 0.05% Streptococcus thermophilus for 1 day at 30° C. to obtain the kiwifruit fermented product.

2. The method according to claim 1 , wherein the prebiotic composition improves bowel movement of the subject, intestinal barrier of the subject, or a combination thereof.

3. The method according to claim 2 , wherein the improvement of bowel movement of the subject comprises reducing defecation difficulty of the subject, promoting intestinal peristalsis frequency of the subject, reducing incomplete defecation of the subject, reducing defecation time of the subject, or a combination thereof.

4. The method according to claim 2 , wherein the prebiotic composition is used for increasing a concentration of a tight junction protein in the blood of the subject.

5. The method according to claim 4 , wherein the tight junction protein is claudin 3 (CLDN3).

6. The method according to claim 1 , wherein the prebiotic composition is used for reducing the subject's weight, waist circumference, body fat percentage, or a combination thereof.

7. The method according to claim 1 , wherein the effective dose is 800 mg/day.

8. The method according to claim 1 , wherein the weight ratio of the kiwifruit fermented product, the inulin, and the fructooligosaccharide is 4:3:3.

9. A method for increasing a concentration of a tight junction protein in blood of a subject in need thereof, comprising administering an effective dose of a prebiotic composition to the subject,

wherein the prebiotic composition consisting of a kiwifruit fermented product, inulin, and fructooligosaccharide,

wherein a weight ratio of the kiwifruit fermented product, the inulin, and the fructooligosaccharide is 3-4:2.5-4:2.5-4,

wherein the kiwifruit is Actinidia deliciosa , and

wherein the kiwifruit fermented product is obtained by the steps of: fermenting Actinidia deliciosa with 0.1% Saccharomyces cerevisiae for 1 day at 30° C. to obtain an initial fermentation broth, and fermenting the initial fermentation broth with 0.05% Streptococcus thermophilus for 1 day at 30° C. to obtain the kiwifruit fermented product,

wherein the tight junction protein is claudin 3 (CLDN3).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2021
From: LIN, YUNG-HSIANG; HUANG, CHU-HAN
To: TCI CO., LTD.
Reel/Frame 058026/0553 →
Continuity (1)
Related Publication 20230144246A1 · May 11, 2023
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