IP Library › Granted Patent US 12,349,704
Granted Patent B2
US 12,349,704 · App. 17/293,664 · Granted Jul 8, 2025

High quality cultured meat, compositions and methods for producing same

Inventors: Neta Lavon (Ness Ziona, IL); Ilona Koren (Rehovot, IL)
Assignee: ALEPH FARMS LTD.
A23L13/42A23J3/22A23L13/45
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Quick Facts
Patent No.
US 12,349,704
App. No.
17/293,664
Granted
Jul 8, 2025
Kind
B2
Abstract

The present invention relates to the field of cultured meat, also referred to as clean meat or cell-based meat, particularly to cell cultures for producing cultured meat having sensory properties (color, taste and aroma) at least resembling whole-animal derived meat and improved nutritional value. The present invention further provides culture media for producing the cell cultures and high-quality cultured meat.

Claims (10)

1. A non-human-animal derived cell culture comprising a plurality of non-human animal-derived cells, wherein at least 60% of the cells comprise a combination of exogenous supplements consisting of cobalamin (B12) and at least one natural colorant selected from the group consisting of alpha-carotene, beta-carotene, lycopene, canthaxanthin, and anthocyanin, and, optionally, at least one additional exogenous supplement selected from the group consisting of iron and/or a salt thereof, yeast extract, bacterial extract, folate (vitamin B9), zinc and/or a salt thereof, selenium and/or a salt thereof, vitamin D, vitamin E, Coenzyme Q10, at least one fatty acid, and a flavoring agent, wherein the combination of exogenous supplements is present in the intracellular space, intramembrane space, on the cell membrane, or any combination thereof upon uptake and accumulation and/or adherence of the exogenous supplement in or on the cells, in an amount sufficient to confer a meat-like color to the non-human-animal derived cell culture, wherein said meat-like color is characterized by the three primary color receptors of the human eye quantified into coordinate values of L*a*b* by colorimeter, wherein the L* value is from about 23 to about 42, the a* value is from about 21 to about 30, and the b* value is from about 11 to about 22.

2. The non-human-animal derived cell culture of claim 1 , wherein the non-human animal-derived cells comprise at least one compound having absorbance at a wavelength or a plurality of wavelengths of from about 300 nm to about 700 nm.

3. The non-human-animal derived cell culture of claim 1 , wherein the non-human-animal derived cells comprise a combination of the at least one natural colorant, vitamin B12 and iron and/or a salt thereof.

4. The non-human-animal derived cell culture of claim 1 , wherein the non-human animal derived cells are pluripotent stem cells (PSCs) and/or cells differentiated therefrom.

5. The non-human-animal derived cell culture of claim 1 , wherein the non-human animal derived cells are induced pluripotent stem cells (iPSCs) reprogrammed from somatic non-human animal cells and/or cells differentiated therefrom.

6. The non-human-animal derived cell culture of claim 1 , wherein the non-human animal derived cells are non-embryonic stem cells (ESCs).

7. The non-human-animal derived cell culture of claim 1 , wherein the non-human animal derived cells are satellite cells.

8. The non-human-animal derived cell culture of claim 1 , wherein the non-human-animal derived cells are selected from the group consisting of muscle cells and progenitors thereof; fat cells and progenitors thereof; stromal cells and progenitors thereof; endothelial cells and progenitors thereof; and any combination thereof.

9. Cultured meat comprising the non-human-animal derived cell culture of claim 1 .

10. The cultured meat of claim 9 , said cultured meat further comprises an edible scaffold.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2021
From: LAVON, NETA; KOREN, ILONA
To: ALEPH FARMS LTD.
Reel/Frame 056231/0543 →
Continuity (2)
Provisional Application 62767525 · Nov 15, 2018
Related Publication 20220007696A1 · Jan 13, 2022
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