Analysis method of analyzing a nucleic acid sequence, and a system that analyzes a nucleic acid sequence
An analysis method of analyzing a nucleic acid sequence derived from a patient sample with a computer, may include: obtaining analysis data relating to a mutation determined based on nucleic acid sequence data derived from the patient sample; and generating a first report providing information relating to the determined mutation in a first form which is different from a second form of a second report, wherein the second report provides information relating to a germline mutation among the determined mutation in the second form.
1. An analysis method of analyzing a nucleic acid sequence derived from a patient sample with a computer, the computer configured with instructions to perform operations comprising:
obtaining from a storage device or a sequencer coupled to the computer, nucleic acid sequence data related to the nucleic acid sequence derived from the patient sample and reference sequence data;
determining a presence of a mutation by:
comparing the obtained nucleic acid sequence data with the reference sequence data;
identifying whether a rate of coincidence between the nucleic acid sequence data and the reference sequence data satisfies a predetermined criteria; and
generating an analysis result based on the comparison;
receiving a selection from among candidate forms each for the same patient associated with the patient sample, the candidate forms comprising a first form and a second form different from the first form, for providing a report of information of the patient and the analysis result based on the determination of the presence of the mutation; and
generating, based on the received selection being the first form, a first report of the analysis result providing information relating to the determined mutation in the first form which is different from the second form, and generating based on the received selection being the second form, a second report of the analysis result providing information relating to the determined mutation in the second form which is different from the first form, wherein
the second report includes the information of the patient and provides information relating to a germline mutation among the determined mutation in the second form, and
the first report includes the information of the patient and does not provide at least part of the information relating to the germline mutation.
2. The analysis method according to claim 1 , wherein the first report provides information relating to the determined mutation in the first form without explicit indication that the determined mutation includes the germline mutation.
3. The analysis method according to claim 1 , wherein the first report provides a mutation position of the determined mutation.
4. The analysis method according to claim 1 , wherein the first report provides a mutation position of the determined mutation without explicit indication that the determined mutation includes the germline mutation.
5. The analysis method according to claim 1 , further comprising receiving account information of a reader of the analysis result of the nucleic acid sequence derived from the patient, wherein
the first report does not provide at least part of the information relating to the germline mutation when the account information indicates that an incidental finding regarding the determined mutation is to be treated as confidential, the incidental finding comprising a nucleic acid sequence mutation other than the determined mutation, which presents in a tumor cell.
6. The analysis method according to claim 1 , wherein the first report further provides information on the patient.
7. The analysis method according to claim 6 , wherein the second report further provides information on the mutation and a gene in which the mutation is detected.
8. The analysis method according to claim 1 , further comprising
generating the second report.
9. The analysis method according to claim 1 , wherein
the receiving the selection comprises receiving prescribed information that indicates a presentation form of the information relating to the germline mutation.
10. A system that analyzes a nucleic acid sequence derived from a patient sample, comprising:
a memory storing instructions; and
a processor in communication with the memory, the processor configured with the instructions to cause the system to perform operations comprising:
obtaining from a storage device or a sequencer coupled to the system, nucleic acid sequence data related to the nucleic acid sequence derived from the patient sample and reference sequence data;
determining a presence of a mutation by comparing the obtained nucleic acid sequence data with the reference sequence data and identifying whether a rate of coincidence between the nucleic acid sequence data and the reference sequence data satisfies a predetermined criteria, and generating an analysis result;
receiving a selection from among candidate forms for the same patient associated with the patient sample, the candidate forms comprising a first form and a second form different from the first form, for providing a report of information of the patient and the analysis result based on the determination of the presence of the mutation; and
generating, based on the received selection being the first form, a first report of the analysis result providing information relating to the determined mutation in the first form which is different from the second form, and generating based on the received selection being the second form, a second report of the analysis result providing information relating to the determined mutation in the second form which is different from the first form, wherein
the second report includes the information of the patient and provides information relating to a germline mutation among the determined mutation in the second form and
the first report includes the information of the patient and does not provide at least part of the information relating to the germline mutation.
11. The system according to claim 10 , wherein the first report provides information relating to the determined mutation in the first form without explicit indication that the determined mutation includes the germline mutation.
12. The system according to claim 10 , wherein the first report provides a mutation position of the determined mutation.
13. The system according to claim 10 , wherein the first report provides a mutation position of the determined mutation without explicit indication that the determined mutation includes the germline mutation.
14. The system according to claim 10 , wherein the processor is configured with the instructions to cause the system to perform operations further comprising receiving account information of a reader of the analysis result of the nucleic acid sequence derived from the patient,
wherein the first report does not provide at least part of the information relating to the germline mutation when the account information indicates that an incidental finding regarding the determined mutation is to be treated as confidential, the incidental finding comprising a nucleic acid sequence mutation other than the determined mutation, which presents in a tumor cell.
15. The system according to claim 10 , wherein the first report further provides information on the patient, and
the second report further provides information on the mutation and a gene in which the mutation is detected.
16. The system according to claim 10 , wherein the processor is configured to cause the system to perform operations further comprising generating the second report.
17. The system according to claim 10 , wherein the receiving the selection comprises receiving prescribed information that indicates a presentation form of the information relating to the germline mutation.