IP Library Granted Patent US 12,359,287
Granted Patent B2
US 12,359,287 · App. 18/099,384 · Granted Jul 15, 2025

Properties and parameters of novel biodegradable metallic alloys

Inventor: Prashant N. Kumta (Pittsburgh, PA)
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
C22C23/06
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,359,287
App. No.
18/099,384
Granted
Jul 15, 2025
Kind
B2
Abstract

The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.

Claims (16)

1. A biodegradable medical implant device, comprising:

a metal alloy, consisting of:

from about 4.0-4.5 weight percent of zinc;

from about 0.3-0.5 weight percent of zirconium;

optionally, from about 0.25-1.0 weight percent of strontium;

optionally, from about 0.25-1.0 weight percent of cerium;

optionally, from about 1.0 to about 9.0 weight percent aluminum;

optionally, from about 0.1 to about 1.0 weight percent manganese;

optionally from about 0.25 to about 1.0 weight percent silver; and

a balance of magnesium including impurities, based on the total weight of the composition,

wherein the metal alloy has an average grain size from about 50 to about 100 μm, and wherein the metal alloy forms a primary phase of Mg (ZnZr), and an intermetallic secondary phase of Mg 7 Zn 3 precipitate is minimized or precluded in the metal alloy.

2. The device of claim 1 , wherein the zinc constitutes about 4.0 weight percent and the zirconium constitutes about 0.5 weight percent.

3. The device of claim 1 , wherein the zinc constitutes about 4.4 weight percent and the zirconium constitutes from about 0.3-0.4 weight percent.

4. The device of claim 1 , wherein strontium and/or cerium is present.

5. The device of claim 1 , wherein aluminum and/or manganese and/or silver is present.

6. The device of claim 1 , wherein the yield strength is 96 MPa or about 286.6 MPa and the ultimate tensile strength is 176 MPa or about 327.2 MPa.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 21, 2023
From: KUMTA, PRASHANT N.
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 065630/0500 →
Continuity (4)
Division 16500928
Provisional Application 62484564 · Apr 12, 2017
Provisional Application 62484560 · Apr 12, 2017
Related Publication 20230313346A1 · Oct 5, 2023
References Cited (18)
US 20080031765A1 · Gerold · 2008 [cited by examiner]
US 20110192500A1 · Uggowitzer et al. · 2011 [cited by applicant]
US 20140248288A1 · Kumta et al. · 2014 [cited by applicant]
US 20170044645A1 · Kumta et al. · 2017 [cited by applicant]
CN 103343273A · 2013 [cited by applicant]
JP H06192799A · 1992 [cited by examiner]
JP 2011524465A · 2011 [cited by applicant]
JP 2014534338A · 2014 [cited by applicant]
WO 2013052791A2 · 2013 [cited by applicant]
WO 2016145368A1 · 2016 [cited by applicant]
WO 2017035072A1 · 2017 [cited by applicant]
JPH06192799A description English machine translation (Year: 1992). [cited by examiner]
JPH06192799A claims English machine translation (Year: 1992). [cited by examiner]
Watanabe et al., Fine-Grain Processing by Equal Channel Angular Extrusion of Rapidly Quenched Bulk Mg—Y—Zn Alloy, Journal of Materials Research (2005), 20.1:93-101. [cited by applicant]
Moosbrugger et al., Corrosion Resistance of Magnesium Alloys, ASM Handbook, ASM International (2003), 13. [cited by applicant]
Chou et al., In Vitro and In Vivo Corrosion, Cell Response, and Biocompatibility of High Strength Mg—Ca—Zr, Mg—Y—Ca—Zr, and Mg—Y—Zn—Ca—Zr Alloys for Orthopaedic Implant Applications, ECM Meeting Abstracts (2016), Collec… [cited by applicant]
Jong et al., In Vitro Degradation and Cytotoxicity Response of Mg-4% Zn-0.5% Zr (ZK40). Alloy as a Potential Biodegradable Material, Acta Biomaterialia (Nov. 1, 2013), 9(1):8534-8547. [cited by applicant]
Extended European Search Report Issued in Ep Patent Application No. 18783808.1 Dated Nov. 20, 2020. [cited by applicant]