IP Library Granted Patent US 12,364,727
Granted Patent B2
US 12,364,727 · App. 17/074,415 · Granted Jul 22, 2025

Method for treating poxvirus infections

Inventors: Jeffrey Langland (Chandler, AZ); Karen Denzler (Phoenix, AZ); Robert Waters (Mesa, AZ); Bertram Jacobs (Tempe, AZ)
A61K36/53A61K9/0034A61K36/185A61K36/254A61K36/38A61K36/484A61K36/68A61K36/88A61P25/00A61P31/20A61P35/00A61K2236/13A61K2236/333A61K2236/37
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Quick Facts
Patent No.
US 12,364,727
App. No.
17/074,415
Granted
Jul 22, 2025
Kind
B2
Abstract

The present disclosure relates generally methods of preparation and use of certain botanical extracts for the treatment of viral infections.

Claims (13)

1. A method for inhibiting the replication of a poxvirus by exposing the poxvirus to an extract from a plant material selected from the group consisting of Sarracenia, Nepenthes, Melissa, Lavandula, Glycyrrhiza, Eleutherococcus, Hypericum, Darlingtonia, Heliamphora, Roridula, Drosera, Dionaea, Aldrovanda, Drosophyllum, Triphyophyllum, Catopsis, Brocchinia, Paepalanthus, Utricularia, Genlisea, Pinguicula, Ibicella, Byblis, Philcoxia, Stylidium , and Cephalotus , wherein the plant material comprises leaves and is prepared by steps comprising:

obtaining fresh plant material less than about ten (10) days following harvest of the plant material;

washing and air drying the plant material;

combining the plant material with a liquid comprising at least one of water, ethanol, and glycerol;

allowing the liquid to extract the plant material at a temperature between about room temperature and simmering for about one (1) to about sixty (60) days, or by boiling for less than about one day to form the liquid extract; and

separating the liquid extract from the plant material.

2. The method of claim 1 , wherein the plant material comprises leaves and roots.

3. The method of claim 1 , wherein the poxvirus is selected from the group consisting of orthopoxvirus, parpoxvirus, avipoxvirus, capripoxvirus, leporipoxvirus, suipoxvirus, molluscipox virus, and yatapox virus.

4. The method of claim 1 , wherein the poxvirus is a human poxvirus.

5. The method of claim 1 , wherein the poxvirus is selected from the group consisting of vaccinia virus, monkeypox virus, variola virus, and mollluscum contagiosum virus.

6. The method of claim 1 , wherein the poxvirus is an animal poxvirus.

7. The method of claim 1 , further comprising a step combining the liquid extract with a food-grade or pharmaceutically acceptable excipient to form a therapeutic composition.

8. The method of claim 7 , wherein the food-grade or pharmaceutically acceptable excipient is a transdermal base carrier or gel.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2024
From: DENZLER, KAREN; JACOBS, BERTRAM; WATERS, ROBERT; LANGLAND, JEFFREY
To: BIOMEDICAL SYSTEMS SOLUTIONS, LLC
Reel/Frame 066265/0875 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2024
From: DENZLER, KAREN; LANGLAND, JEFFREY; JACOBS, BERTRAM; WATERS, ROBERT
To: BIOMEDICAL SYSTEMS SOLUTIONS, LLC
Reel/Frame 068169/0788 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2024
From: BIOMEDICAL SYSTEMS SOLUTIONS
To: AVIRATEK BIOMEDICAL SOLUTIONS, LLC
Reel/Frame 066069/0032 →
Continuity (4)
Continuation 16261816 · Jan 30, 2019
Continuation 14443767
Provisional Application 61729204 · Nov 21, 2012
Related Publication 20220062365A1 · Mar 3, 2022
References Cited (5)
US 10842838B2 · Langland · 2020 [cited by examiner]
US 20210275620A1 · Langland · 2021 [cited by examiner]
Arndt, W. et al. In vitro Characterization of a Nineteenth Century Therapy for Smallpox. PLoS One 7(3)1-9, Mar. 2012. (Year: 2012). [cited by examiner]
Ruiz, G. et al. A Lack of Bioactive Predictability for Marker Compounds Commonly Used for Herbal Medicine. PLoS One 11(7)1-10, Jul. 26, 2016. (Year: 2016). [cited by examiner]
Miles HS. (On the employment of the Sarracenia purpurea, or Indian Pitcher Plant, as a remedy for smallpox. The Lancet. 1862;80: 430-431). (Year: 1862). [cited by examiner]