Granted Patent B2

US 12,365,731 · App. 17/852,419 · Granted Jul 22, 2025

Inventors: Nadia Anceriz (Aubagne, FR); Mathieu Blery (Marseilles, FR); Laurent Gauthier (Marseilles, FR); Carine Paturel (Marcy l'Etoile, FR)

Assignee: INNATE PHARMA

C07K16/2803A61K47/68035A61K47/6849A61P35/00C07K16/30G01N33/56972C07K2317/33C07K2317/732C07K2317/92

Abstract

Claims (14)

1. A nucleic acid or set of nucleic acids encoding an antibody, an antibody fragment, or a protein comprising said antibody fragment, said nucleic acid encoding an antibody or antibody fragment selected from the group consisting of:

(a) an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 3 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 4;

(b) an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 3 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 21;

(c) an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 29 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 30;

(d) an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 29 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 47; and

(e) an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 55 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 56.

2. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 3 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 4.

3. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 3 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 21.

4. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding an antibody or antibody fragment comprising (i) a heavy chain comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 29 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 30.

5. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding an antibody or antibody fragment comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 29 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 47.

6. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding an antibody or antibody fragment comprising CDR 1, 2 and 3 of the heavy chain variable region of SEQ ID NO: 55 and (ii) a light chain comprising CDR 1, 2 and 3 of the light chain variable region of SEQ ID NO: 56.

7. The nucleic acid or set of nucleic acids of claim 1 , said nucleic acid or set of nucleic acids encoding a protein comprising said antibody fragment.

8. The nucleic acid or set of nucleic acids of claim 7 , said nucleic acid or set of nucleic acids encode a chimeric cell surface receptor protein comprising said antibody fragment.

9. A recombinant host cell comprising the nucleic acid of claim 1 .

Assignments (1)

Continuity (4)

References Cited (9)