Sealant dressing with protected reactive components
The present invention is directed to multi-layered wound dressings having a carrier layer, at least two sublayers, wherein each sublayer contains at least one reactive, cross-linkable component and the at least two reactive, cross-linkable components are co-reactive with the other and at least one reactive, cross-linkable has a protective leaving group and a buffering salt agent.
1. A multi-layered wound dressing consisting of:
a. a bi-layer carrier substrate consisting of a layer of oxidized cellulose joined to a layer of fibers composed of a copolymer made from 90% glycolide and 10% L-lactide;
b. a coating consisting of stacked spray-coated layers of
a layer of alkaline buffer immediately on the carrier substrate,
a layer of PEG-N-hydroxysuccinimide, and
a layer of protected PEG-amine end-capped with a plurality of hydrohalide protective leaving groups between the layer of alkaline buffer and the layer of PEG-N-hydroxysuccinimide,
wherein the alkaline buffer is disodium tetraborate, bis-tris methane (Bis-Tris), or 2-(N-morpholino) ethanesulfonic acid (MES).
2. The multilayered wound dressing according to claim 1 , wherein the carrier substrate has at least two chemically distinct layers that are structurally integrated via ultrasonic welding, needle punching, heat welding, chemical attachment, suture attachment or combinations thereof.
3. The multi-layered wound dressing according to claim 1 wherein the hydrohalide protective leaving group reacts with the alkaline buffer to render a primary amine group available for reaction.
4. The multi-layered wound dressing of claim 1 that has been subjected to pliabilization to increase flexibility.