IP Library › Granted Patent US 12,383,578
Granted Patent B2
US 12,383,578 · App. 17/776,643 · Granted Aug 12, 2025

Carbazate-activated polyvinyl alcohol (PVAC) as a polymer-based antitumoral agent

Inventors: David Berglund (New York, NY); Erik Berglund (New York, NY); Felix Sellberg (Uppsala, SE); Robin Fröbom (Stockholm, SE)
Assignee: CreMed AB
A61K31/785A61K45/06A61P17/00A61P35/00C08F116/06
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Quick Facts
Patent No.
US 12,383,578
App. No.
17/776,643
Granted
Aug 12, 2025
Kind
B2
Abstract

The present invention provides a polymer comprising a carbazate-modified polyvinyl alcohol (PVAC) according to Formula I for use in preventing, alleviating, and/or treating cancer, and a method for producing said compound.

Claims (10)

1. A method for alleviating and/or treating cancer in a subject comprising administering a therapeutically effective amount of a polymer comprising a carbazate-modified polyvinyl alcohol (PVAC) of Formula I,

wherein,

unmodified repeat units of PVA are denoted with n and carbazate groups conjugated to repeat units are denoted by m,

to a subject in need of such treatment.

2. The method according to claim 1 , wherein the cancer is selected from melanoma, gastrointestinal cancer, T-cell lymphoma, B-cell lymphoma and Hedgin's lymphoma.

3. The method according claim 1 , wherein the administration is performed by intravenous, intramuscular, intraperitoneal, or subcutaneous injection or infusion.

4. The method according to claim 1 in combination with another anticancer treatment.

5. The method according to claim 1 , wherein the polymer has a degree of polymerization in the range of 100<DP<2000.

6. The method according to claim 1 , wherein the polymer has a degree of substitution (DS) of carbazide in the range of 0.5-50%.

7. The method according to claim 1 , wherein the polymer has a carbazate content in the range of 0.1-10 mmol/g polyvinyl alcohol carbazate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2022
From: BERGLUND, DAVID; BERGLUND, ERIK; SELLBERG, FELIX; FROBOM, ROBIN
To: CREMED AB
Reel/Frame 060579/0437 →
Priority Claims (1)
SE 1930380-9 · Nov 21, 2019 · national
Continuity (1)
Related Publication 20220401470A1 · Dec 22, 2022
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