Isopaucifloral F phosphate compound and pharmaceutical use thereof
The present invention pertains to the technical field of biomedicine, and relates to isopaucifloral F phosphate compounds and pharmaceutical uses thereof. It has been confirmed through experiments that said isopaucifloral F phosphate compounds and pharmaceutically acceptable salts thereof have effects on the bone remodeling process by exerting their anti-osteoporosis efficacy through a dual-mode mechanism of action of promoting osteogenesis and reducing osteoclast resorption, have the characteristics of high bioavailability, stable metabolism and good safety, and can be used to prepare a new generation of anti-osteoporosis drugs.
1. An isopaucifloral F phosphate compound of the following formula (1) and pharmaceutically acceptable salts thereof:
wherein R 1 is independently a phosphate group or a hydrogen atom; and R 2 is independently a phosphate group, wherein the phosphate group is
2. The isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , characterized in that said R 1 ═H, and R 2 is a phosphate group, wherein the phosphate group is
3. The isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , characterized in that said R 1 ═R 2 , and is a phosphate group, wherein the phosphate group is
4. The isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , characterized in that said compound is of the structure selected from:
5. The isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , characterized in that they are racemic mixtures.
6. The isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , characterized in that they are optically pure isomers with a C3-position configuration being an R or S configuration.
7. A method of treating osteoporosis comprising administering an effective amount of an isopaucifloral F phosphate compound or pharmaceutically acceptable salts thereof of claim 1 .
8. A pharmaceutical composition for treating osteoporosis, comprising the isopaucifloral F phosphate compound and pharmaceutically acceptable salts thereof as recited in claim 1 , and pharmaceutically acceptable excipients.