Granted Patent B2

US 12,391,799 · App. 18/161,773 · Granted Aug 19, 2025

Inventor: Xiaoxi Wei (El Cerrito, CA)

Assignee: X-THERMA, INC.

C08G69/10A23B2/762A23B2/85A23L13/422A61K8/64A61K8/88C07K7/08C09K3/18A61K2800/54

Abstract

Claims (21)

1. A peptoid polymer or salt thereof having the sequence [H 2 P 2 ] n , [P 2 H 2 ] n , X-[H 2 P 2 ] n -Y, X-[P 2 H 2 ] n -Y, [H 2 P 2 ] n H 2 , [P 2 H 2 ] n H 2 , [H 2 P 2 ] n P 2 , or [P 2 H 2 ] n P 2 ,

wherein the subscript n is between 2 and 5;

wherein H is a hydrophobic peptoid monomer selected from the group consisting of

wherein the subscript m is the number of repeat units and is between 1 and 10,

wherein P is a polar peptoid monomer selected from the group consisting of

and

wherein X and Y are independently selected from the group consisting of H, optionally substituted C 1-8 alkyl, optionally substituted C 1-8 acyl, optionally substituted C 1-8 alkylamino,-OH,-SH,-NH 2 , secondary amine, tertiary amine, carboxy, optionally substituted C 1-8 hydroxyalkyl, optionally substituted C 1-8 alkylamino, optionally substituted C 2-8 alkylthio, optionally substituted C 1-8 carboxyalkyl, and halogen.

2. The peptoid polymer or salt thereof of claim 1 ,

wherein the peptoid polymer forms a helical structure.

3. The peptoid polymer or salt thereof of claim 1 ,

wherein the peptoid polymer salt is selected from the group consisting of a hydrochloride salt, acetate salt, sulfate salt, phosphate salt, maleate salt, citrate salt, mesylate salt, nitrate salt, tartrate salt, gluconate salt, and a combination thereof.

4. A peptoid-peptide hybrid or salt thereof comprising a peptoid polymer or salt thereof of claim 1 and one or more amino acids, wherein the one or more amino acids are located at one or both ends of the peptoid polymer.

5. The peptoid-peptide hybrid or salt thereof of claim 4 , wherein the one or more amino acids are selected from the group consisting of alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, arginine, lysine, leucine, methionine, asparagine, proline, glutamine, serine, threonine, valine, tryptophan, tyrosine, and a combination thereof.

6. The peptoid-peptide hybrid or salt thereof of claim 4 , wherein the peptoid-peptide hybrid salt is selected from the group consisting of a hydrochloride salt, acetate salt, sulfate salt, phosphate salt, maleate salt, citrate salt, mesylate salt, nitrate salt, tartrate salt, gluconate salt, and a combination thereof.

7. A cryopreservation solution comprising a peptoid polymer or salt thereof of claim 1 .

8. A cosmetic care product comprising a peptoid polymer or salt thereof of claim 1 .

9. An antifreeze product comprising a peptoid polymer or salt thereof of claim 1 .

10. The antifreeze product of claim 9 , wherein the antifreeze product is a deicing or ice-inhibiting product used to prevent, inhibit, or delay the formation of ice on or within an object.

11. The antifreeze product of claim 10 , wherein the object is selected from the group consisting of an aircraft or a part thereof, a gas pipeline, a window, electrical equipment, a drone, a cable, a power line, mechanical equipment, a car engine, a gear system, and a brake system.

12. A frozen food product comprising a peptoid polymer or salt thereof of claim 1 .

13. The frozen food product of claim 12 , wherein the frozen food product is selected from the group consisting of ice cream, yogurt, seafood, fruit, and meat products.

Assignments (1)

Continuity (4)

References Cited (64)