IP Library › Granted Patent US 12,392,313
Granted Patent B2
US 12,392,313 · App. 18/624,533 · Granted Aug 19, 2025

Bodily emission analysis

Inventors: Ishay Attar (M.P. Hof Carmel, IL); Yaara Kapp-Barnea (Nirit, IL)
Assignee: OUTSENSE DIAGNOSTICS LTD.
F03B13/16A61B10/0038A61B10/007B63B35/44G01J3/10G01J3/2803G01J5/0806G01J5/0808G01J5/10G01N21/31G01N21/645G01N21/6486G01N33/493A61B2010/0006B63B2035/4466E03D11/13F05B2240/93F05B2240/95G01J2003/104G01J3/42G01N2021/6421G01N33/57419
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Quick Facts
Patent No.
US 12,392,313
App. No.
18/624,533
Granted
Aug 19, 2025
Kind
B2
Abstract

Apparatus and methods are described for use with a bodily emission of a subject that is disposed within a toilet bowl. One or more light sensors are configured to receive light from the toilet bowl, while the bodily emission is disposed within the toilet bowl. A computer processor detects a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism, by analyzing the received light, and determines that there is a presence of the microorganism within the bodily emission in response thereto. Other applications are also described.

Claims (33)

1. An apparatus for use with a bodily emission of a subject that is disposed within a toilet bowl, the apparatus comprising:

one or more light sensors that are configured to receive light from the toilet bowl, while the bodily emission is disposed within the toilet bowl; and

a computer processor configured to:

detect a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism, by analyzing the received light, and

in response thereto, determine that there is a presence of the microorganism within the bodily emission.

2. The apparatus according to claim 1 , wherein the computer processor is configured to detect a set of three or more spectral components that have a characteristic trough-peak-trough pattern in the light spectrum of the microorganism.

3. The apparatus according to claim 1 , wherein the computer processor is configured to detect the set of spectral components that have the characteristic relationship with each other in a light spectrum of a microorganism selected from the group consisting of: L. plantarum and E. Coli , by analyzing the received light.

4. The apparatus according to claim 1 , wherein the bodily emission includes feces, and wherein the computer processor is configured to determine that there is a presence of the microorganism within the bodily emission by determining that there is a presence of the microorganism within the feces.

5. The apparatus according to claim 1 , wherein the bodily emission includes urine, and wherein the computer processor is configured to determine that there is a presence of the microorganism within the bodily emission by determining that there is a presence of the microorganism within the urine.

6. The apparatus according to claim 1 , wherein the computer processor is configured to generate an output indicating that the subject should visit a healthcare professional, in response to determining that there is a presence of the microorganism within the bodily emission.

7. The apparatus according to claim 1 , wherein the computer processor is configured to generate an output indicating a predicted upcoming inflammatory bowel disease episode, in response to determining that there is a presence of the microorganism within the bodily emission.

8. The apparatus according to claim 1 , wherein the computer processor is configured to detect the set of three or more spectral components that have the characteristic relationship with each other in the light spectrum of the microorganism at least partially by detecting one or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light.

9. The apparatus according to claim 8 , wherein the computer processor is configured to detect the set of three or more spectral components that have the characteristic relationship with each other in the light spectrum of the microorganism by detecting three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light, the three or more spectral components having a characteristic relationship with each other in a fluorescent spectrum of the microorganism.

10. The apparatus according to claim 8 , wherein the computer processor is configured to detect the three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light, by detecting three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light, the microorganism being selected from the group consisting of: L. plantarum and E. Coli.

11. A method for use with a bodily emission of a subject that is disposed within a toilet bowl, the method comprising:

while the bodily emission is disposed within the toilet bowl, receiving light from the toilet bowl using one or more light sensors; and

using a computer processor:

detecting a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism, by analyzing the received light; and

in response thereto, determining that there is a presence of the microorganism within the bodily emission.

12. The method according to claim 11 , wherein detecting the set of three or more spectral components that have the characteristic relationship with each other in the light spectrum of the microorganism comprises detecting a set of three or more spectral components that have a characteristic trough-peak-trough pattern in the light spectrum of the microorganism.

13. The method according to claim 11 , wherein detecting the set of three or more spectral components that have the characteristic relationship with each other in the light spectrum of the microorganism comprises detecting a set of spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism selected from the group consisting of: L. plantarum and E. Coli , by analyzing the received light.

14. The method according to claim 11 , wherein the bodily emission includes feces, and wherein determining that there is a presence of the microorganism within the bodily emission comprises determining that there is a presence of the microorganism within the feces.

15. The method according to claim 11 , wherein the bodily emission includes urine, and wherein determining that there is a presence of the microorganism within the bodily emission comprises determining that there is a presence of the microorganism within the urine.

16. The method according to claim 11 , further comprising generating an output indicating that the subject should visit a healthcare professional, in response to determining that there is a presence of the microorganism within the bodily emission.

17. The method according to claim 11 , further comprising generating an output indicating a predicted upcoming inflammatory bowel disease episode, in response to determining that there is a presence of the microorganism within the bodily emission.

18. The method according to claim 11 , wherein detecting the set of three or more spectral components that have the characteristic relationship with each other in the light spectrum of the microorganism comprises detecting one or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light.

19. The method according to claim 18 , wherein detecting one or more spectral components that are characteristic spectral components at which the given microorganism emits fluorescent light comprises detecting three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light, the three or more spectral components having a characteristic relationship with each other in a fluorescent spectrum of the microorganism.

20. The method according to claim 19 , wherein detecting the three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light comprises detecting three or more spectral components that are characteristic spectral components at which the microorganism emits fluorescent light, the microorganism being selected from the group consisting of: L. plantarum and E. Coli.

21. An apparatus for use with a bodily emission of a subject that is disposed within a toilet bowl, the apparatus comprising:

one or more light sensors that are configured to receive light from the toilet bowl, while the bodily emission is disposed within the toilet bowl; and

a computer processor configured to:

detect a set of spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism selected from the group consisting of: L. plantarum and E. Coli , by analyzing the received light, and

in response thereto, determine that there is a presence of the selected microorganism within the bodily emission.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2024
From: ATTAR, ISHAY; KAPP-BARNEA, YAARA
To: OUTSENSE DIAGNOSTICS LTD
Reel/Frame 066980/0218 →
Continuity (5)
Continuation 18085685 · Dec 21, 2022
Continuation 17462147 · Aug 31, 2021
Continuation 16325632
Provisional Application 62381288 · Aug 30, 2016
Related Publication 20240248041A1 · Jul 25, 2024
References Cited (131)
US 4636474A · Ogura et al. · 1987 [cited by applicant]
US 5277181A · Mendelson et al. · 1994 [cited by applicant]
US 5730149A · Nakayama et al. · 1998 [cited by applicant]
US 5885526A · Chu · 1999 [cited by applicant]
US 6006119A · Soller et al. · 1999 [cited by applicant]
US 6572564B2 · Ito et al. · 2003 [cited by applicant]
US 6844195B2 · Craine · 2005 [cited by applicant]
US 7749217B2 · Podhajsky · 2010 [cited by applicant]
US 8277751B2 · Hill et al. · 2012 [cited by applicant]
US 8750952B2 · Aalders · 2014 [cited by applicant]
US 8911368B2 · Rabinovitz et al. · 2014 [cited by applicant]
US 9029161B2 · Aalders et al. · 2015 [cited by applicant]
US 10575830B2 · Attar · 2020 [cited by examiner]
US 11064886B2 · Prokopp · 2021 [cited by applicant]
US 11129599B2 · Attar · 2021 [cited by examiner]
US 11467091B2 · Attar · 2022 [cited by examiner]
US 11561181B2 · Attar · 2023 [cited by examiner]
US 11604177B1 · Park et al. · 2023 [cited by applicant]
US 11971356B2 · Attar · 2024 [cited by examiner]
US 20030232446A1 · Scholl et al. · 2003 [cited by applicant]
US 20050037505A1 · Samsoondar · 2005 [cited by applicant]
US 20050154277A1 · Tang et al. · 2005 [cited by applicant]
US 20050261605A1 · Shemer et al. · 2005 [cited by applicant]
US 20100099139A1 · Ben-david et al. · 2010 [cited by applicant]
US 20110051125A1 · Kim · 2011 [cited by applicant]
US 20110306855A1 · Rabinovitz et al. · 2011 [cited by applicant]
US 20120196271A1 · Ingber · 2012 [cited by applicant]
US 20140147924A1 · Wheeldon et al. · 2014 [cited by applicant]
US 20150359522A1 · Recht et al. · 2015 [cited by applicant]
US 20160000378A1 · Hall et al. · 2016 [cited by applicant]
US 20160120449A1 · Chiba · 2016 [cited by applicant]
US 20160278705A1 · Han et al. · 2016 [cited by applicant]
US 20170303901A1 · Sekine · 2017 [cited by applicant]
US 20170307512A1 · Akagawa et al. · 2017 [cited by applicant]
US 20180085098A1 · Attar · 2018 [cited by applicant]
US 20180303466A1 · Kashyap et al. · 2018 [cited by applicant]
US 20190195802A1 · Attar et al. · 2019 [cited by applicant]
US 20200100771A1 · Attar · 2020 [cited by applicant]
US 20210333214A1 · Olguin Alvarez et al. · 2021 [cited by applicant]
US 20210389250A1 · Attar et al. · 2021 [cited by applicant]
US 20230121436A1 · Attar et al. · 2023 [cited by applicant]
DE 10106409A1 · 2002 [cited by applicant]
EP 1167971A2 · 2002 [cited by applicant]
EP 3159691A1 · 2017 [cited by applicant]
JP H05126826A · 1993 [cited by applicant]
JP H07113804 · 1995 [cited by applicant]
JP H0978656A · 1997 [cited by applicant]
JP H1114622A · 1999 [cited by applicant]
JP 2000241347A · 2000 [cited by applicant]
JP 2005037278A · 2005 [cited by applicant]
JP 2005524441A · 2005 [cited by applicant]
JP 2006189338A · 2006 [cited by applicant]
JP 2007252805A · 2007 [cited by applicant]
JP 2012532122A · 2012 [cited by applicant]
JP 2015500471A · 2015 [cited by applicant]
JP 2016004005A · 2016 [cited by applicant]
JP 2020201279A · 2020 [cited by applicant]
KR 20170078450A · 2017 [cited by applicant]
WO 2011097412A1 · 2011 [cited by applicant]
WO 2011123776A2 · 2011 [cited by applicant]
WO 2013082267A1 · 2013 [cited by applicant]
WO 2014171018A1 · 2014 [cited by applicant]
WO 2014192781A1 · 2014 [cited by applicant]
WO 2015194405A1 · 2015 [cited by applicant]
WO 2016063547A1 · 2016 [cited by applicant]
WO 2016135735A1 · 2016 [cited by applicant]
WO 2018042431A1 · 2018 [cited by applicant]
WO 2018222939A1 · 2018 [cited by applicant]
WO 2021205345A1 · 2021 [cited by applicant]
Corrected Notice of Allowance for U.S. Appl. No. 15/553,366 mailed Jan. 29, 2020. [cited by applicant]
Corrected Notice of Allowance for U.S. Appl. No. 15/553,366 mailed Nov. 18, 2018. [cited by applicant]
Corrected Notice of Allowance for U.S. Appl. No. 17/412,962 mailed Sep. 19, 2023. [cited by applicant]
Corrected Notice of Allowance for U.S. Appl. No. 17/462,147 mailed Nov. 17, 2022. [cited by applicant]
European Search Report for European Application No. 16754866.8 mailed Nov. 15, 2018. [cited by applicant]
Examination Report for Australian Application No. 2016224850 mailed May 3, 2021. [cited by applicant]
Examination Report for Australian Application No. 2016224850 mailed Sep. 11, 2020. [cited by applicant]
Examination Report for Canadian Application No. 2,977,743 mailed Dec. 16, 2022. [cited by applicant]
Examination Report for Canadian Application No. 2,977,743 mailed Mar. 22, 2022. [cited by applicant]
Examination Report for European Application No. 21180648.4 mailed Jul. 20, 2023. [cited by applicant]
Extended European Search Report for European Patent Application No. 21180648.4 mailed Oct. 28, 2021. [cited by applicant]
First Action Interview Office Action received for U.S. Appl. No. 16/700,423 mailed Feb. 5, 2021. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2021/052856 mailed Sep. 3, 2021. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IL2016/050223 mailed Jun. 7, 2016. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IL2017/050966 mailed Nov. 28, 2017. [cited by applicant]
Invitation to Pay Additional Fees for International Application No. PCT/IB2021/052856 mailed Jul. 8, 2021. [cited by applicant]
Issue Notification for U.S. Appl. No. 15/553,366 mailed Dec. 11, 2019. [cited by applicant]
Issue Notification for U.S. Appl. No. 16/325,632 mailed Sep. 21, 2022. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/412,962 mailed Sep. 27, 2023. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/462,147 mailed Jan. 4, 2023. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 15/553,366 mailed Feb. 11, 2019. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/412,962 mailed Nov. 28, 2022. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 18/085,685 mailed May 26, 2023. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 15/553,366 mailed Aug. 28, 2019. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 16/325,632 mailed Aug. 9, 2022. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 16/700,423 mailed May 27, 2021. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/412,962 mailed Jun. 13, 2023. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/462,147 mailed Sep. 28, 2022. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 18/085,685 mailed Jan. 9, 2024. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 18/085,685 mailed Sep. 8, 2023. [cited by applicant]
Office Action and English Summary for Chinese Application No. 201680015869.0 mailed Aug. 16, 2019. [cited by applicant]
Office Action and English Translation for Japanese Application No. 2017-544028 mailed Dec. 3, 2019. [cited by applicant]
Office Action for Chinese Application No. 201680015869.0 mailed Jun. 5, 2020. [cited by applicant]
Office Action for Japanese Application No. 2019-510400 mailed Jul. 7, 2021. [cited by applicant]
Office Action for Japanese Application No. 2020-146892 mailed Sep. 15, 2021. [cited by applicant]
Office Action for Japanese Application No. 2022-022279 mailed Aug. 24, 2023. [cited by applicant]
Office Action for Japanese Application No. 2022-022279 mailed Feb. 3, 2023. [cited by applicant]
Office Action for Japanese Application No. 2022-075244 mailed Jul. 3, 2023. [cited by applicant]
Office Action for Japanese Application No. 2022-075244 mailed Mar. 3, 2023. [cited by applicant]
Office Action for Japanese Application No. 2022-075244 mailed Oct. 20, 2023. [cited by applicant]
Office Action for Korean Application No. 10-2023-7021073 mailed Aug. 16, 2023. [cited by applicant]
Office Action for KR 10-2017-7027062 mailed Apr. 25, 2022 with English machine translation and partial English translation by associate. [cited by applicant]
Preinterview First Office Action for U.S. Appl. No. 16/700,423 mailed Dec. 24, 2020. [cited by applicant]
Supplementary Extended European Search Report for Application No. 17845672.9 mailed Jul. 17, 2019. [cited by applicant]
U.S. Appl. No. 15/553,366, filed Aug. 24, 2017. [cited by applicant]
U.S. Appl. No. 16/325,632, filed Feb. 14, 2019. [cited by applicant]
U.S. Appl. No. 16/700,423, filed Dec. 2, 2019. [cited by applicant]
U.S. Appl. No. 17/412,962, filed Aug. 26, 2021. [cited by applicant]
U.S. Appl. No. 17/462,147, filed Aug. 31, 2021. [cited by applicant]
U.S. Appl. No. 18/085,685, filed Dec. 21, 2022. [cited by applicant]
U.S. Appl. No. 62/120,639, filed Feb. 25, 2015. [cited by applicant]
U.S. Appl. No. 62/381,288, filed Aug. 30, 2016. [cited by applicant]
Cullen, et al., “Hyperspectral Imaging for Non-Contact Analysis of Forensic Traces”, Forensic Science International, Oct. 22, 2012. [cited by applicant]
Imai, et al., “The Effective Method of Feces for Occult Blood Test in the Detection of Colorectal Cancer”, Second Department of Surgery, Yokohama City University, School of Medicine, 1992, 9 pages. [cited by applicant]
Monici, “Natural flourescence of white blood cells: spectroscopic and imaging study”, Journal of Photochemistry and photobilology B:Biology 30, 1995, pp. 29-37. [cited by applicant]
Russo, et al., “Hemoglobin, Isolation and Chemical Properties”, Journal of Chemical Education, May 1973, pp. 347-350. [cited by applicant]
Extended European Search Report for European Application No. 23207909.5 mailed Feb. 28, 2024. [cited by applicant]
Issue Notification for U.S. Appl. No. 18/085,685 mailed Apr. 10, 2024. [cited by applicant]
U.S. Appl. No. 18/624,533, filed Apr. 2, 2024. [cited by applicant]
Office Action for Japanese Application No. 2024-031393 mailed Aug. 23, 2024. [cited by applicant]
U.S. Appl. No. 19/041,133, filed Jan. 30, 2025. [cited by applicant]
U.S. Appl. No. 63/548,651, filed Feb. 1, 2024. [cited by applicant]
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