Putrescine topical barrier formulation
The present invention describes stable topical barrier compositions comprising primary polyamines and uses thereof for protecting the skin from external stressors, for improving skin's moisture and fort stimulating healing of the skin. These compositions may be used in a variety of cosmetic and therapeutic applications including for promoting wound healing, for reducing or preventing the formation of hypertrophic scar tissue, for reducing or preventing skin irritation and inflammation, for increasing skin's moisture and/or for reducing or preventing skin's signs of aging.
1. A topical water free barrier composition comprising: (i) a primary aliphatic lower-alkyl (C1-5) polyamine in a concentration of between about 0.1% w/w to about 1% w/w; (ii) a phospholipid to encapsulate the primary polyamine, the phospholipid being cocamidopropyl PG-dimonium chloride phosphate in a concentration of between about 3% w/w and about 6% w/w; (iii) petroleum jelly in a concentration of between about 25% w/w and 65% w/w; and (iv) mineral oil in a concentration of between about 30% w/w and about 45% w/w.
2. The barrier composition of claim 1 , wherein the polyamine is putrescine or dansylcadaverine.
3. The barrier composition of claim 1 , wherein the polyamine is putrescine.
4. The barrier composition of claim 3 , wherein the putrescine is in a concentration of between about 0.4% w/w and about 0.8% w/w.
5. The barrier composition of claim 1 , wherein the petroleum jelly is in a concentration of about 45% w/w.
6. The barrier composition of claim 1 , wherein the mineral oil is in a concentration of about 35% w/w.
7. The barrier composition of claim 1 , wherein the cocamidopropyl PG-dimonium chloride phosphate is in a concentration of about 4% w/w.
8. The barrier composition of claim 1 , further comprising (i) paraffin; (ii) lanolin oil; (iii) a lipophilic Vitamin C derivative; (iv) one or more humectants; and/or (v) bisabolol.
9. The barrier composition of claim 8 , wherein the paraffin is in a concentration of between about 3% w/w and 15% w/w.
10. The barrier composition of claim 8 , wherein the lanolin oil is in a concentration of between about 3% w/w and 6% w/w.
11. The barrier composition of claim 8 , wherein the lipophilic Vitamin C derivative is in a concentration of between about 0.1% w/w and 10% w/w.
12. The barrier composition of claim 8 , wherein the lipophilic Vitamin C derivative comprises 3-O-Ethyl Ascorbic Acid (3-O-EAA).
13. The barrier composition of claim 12 , wherein the 3-O-EAA is in a concentration of about 0.5% w/w.
14. The barrier composition of claim 8 , wherein the one or more humectants is(are) in a concentration of between about 0.5% w/w and 3% w/w.
15. The barrier composition of claim 8 , wherein the one or more humectants comprise(s) glycerin, vitamin B5 or a combination thereof.
16. The barrier composition of claim 15 , wherein the one or more humectants comprise(s) about 1% w/w of the glycerin and about 1% w/w of the Vitamin B5.
17. The barrier composition of claim 8 , wherein the bisabolol is in a concentration of between about 0.1% w/w and 1% w/w.
18. A method of using the barrier composition defined in claim 1 , for (i) treating of skin inflammation, treating skin irritation and/or reducing skin's signs of aging; (ii) promoting wound healing; or (iii) reducing formation of hypertrophic scar tissue, comprising topically administering the barrier composition on a subject.