Granted Patent B2

US 12,397,030 · App. 17/784,168 · Granted Aug 26, 2025

Inventors: Annalouise O'Connor (Gig Harbor, WA); Mark Houston (Nashville, TN)

Assignee: METAGENICS LLC

A61K36/185A61K31/01A61K31/05A61K31/352A61P3/06

Abstract

Claims (13)

1. A composition comprising:

I) a synergistic combination consisting essentially of:

i) pomegranate extract with a total polyphenol content of 50% by weight or greater, and a punicalagin content of 30% by weight or greater;

ii) quercetin; and

iii) lycopene;

II) Vitamin E; and

III) at least one inactive ingredient selected from the group consisting of microcrystalline cellulose, silicon dioxide, magnesium stearate, and combinations thereof;

wherein the ratio of the total weight of the pomegranate polyphenols to total weight quercetin and lycopene in the composition is from about 1:0.1 to about 1:10;

wherein the composition is in the form of a serving, and wherein the pomegranate extract is present in the serving in an amount of from about 200 to about 600 mg, the quercetin is present in the serving in an amount of from about 500 to about 1500 mg, and the lycopene is present in the serving in an amount of from about 1 to about 50 mg; and

wherein the composition is encapsulated in hydroxypropyl methylcellulose or hypromellose and is in the form of at least one tablet, capsule, or caplet.

2. The composition of claim 1 , wherein the pomegranate extract is pomegranate polyphenols.

3. The composition of claim 1 , wherein the pomegranate extract is present in an amount of from about 15 wt. % to about 40 wt. %, the quercetin is present in an amount of from about 35 wt. % to about 85 wt. %, and the lycopene is present in an amount of from about 0.1 wt. % to about 5 wt. %, each based on 100 parts by weight of the pomegranate extract, quercetin, and lycopene.

4. The composition of claim 1 , comprising 28.2% by weight pomegranate polyphenols and 71.8% by weight of the combination of quercetin and lycopene.

Assignments (3)

Continuity (2)

References Cited (64)