Long-term medicament storage apparatus and methods
An apparatus for storing a medicament delivery device, the apparatus comprising: a container defining a storage cavity having an opening, the storage cavity configured to receive a syringe pre-filled with medicament; an absorbent disposed in the cavity, the absorbent at least partially hydrated with a liquid solution; and a seal member at least selectively connected with the cavity to form a seal that is at least substantially gas impermeable.
1. An apparatus for storing a medicament delivery device, the apparatus comprising:
a container defining a storage cavity having an opening;
a syringe pre-filled with medicament and disposed in the storage cavity;
an absorbent disposed in the storage cavity, the absorbent at least partially hydrated with a liquid solution; and
a seal member at least selectively connected with the storage cavity to form a seal that is at least substantially gas impermeable.
2. The apparatus of claim 1 , wherein the cavity of the container and its contents are sterile.
3. The apparatus of claim 1 , further comprising a gas permeable seal member disposed on the container over at least part of the opening enclosing at least part of the cavity containing the syringe, the gas permeable seal member disposed between the seal member and the container.
4. The apparatus of claim 3 , wherein the cavity comprises a first sub-cavity and a second sub-cavity separated by a container wall, the first sub-cavity containing the syringe and the second sub-cavity containing the absorbent.
5. The apparatus of claim 4 , wherein the gas-permeable seal member is disposed over the first sub-cavity but not the second sub-cavity, and the seal member is disposed over the first and second sub-cavities.
6. The apparatus of claim 1 , wherein the absorbent is at least partially hydrated with a water solution.
7. The apparatus of claim 1 , wherein the seal member is a sealed gas-impermeable bag in which the container, the syringe, and the absorbent are disposed.
8. A method of packaging a medicament delivery device for storage, the method comprising:
providing a container defining a storage cavity and an opening;
disposing a syringe pre-filled with a medicament in the storage cavity of the container;
disposing an absorbent in the storage cavity of the container, the absorbent being at least partially hydrated with a liquid solution; and
sealing the storage cavity of the container with a seal member by at least selectively connecting the seal member with cavity to form a seal that is at least substantially gas impermeable.
9. The method of claim 8 , wherein sealing the storage cavity of the container comprises sealing the seal member to the container adjacent to the opening to enclose the storage cavity.
10. The method of claim 8 , further comprising sterilizing the storage cavity and the syringe prior to sealing the storage cavity of the container with the seal member.
11. The method of claim 10 , wherein sterilizing the storage cavity and the syringe comprises exposing the storage cavity and the syringe to a vapor phase hydrogen peroxide (VPHP) sterilizing process.
12. The method of claim 10 , further comprising sealing at least part of the storage cavity containing the syringe with a gas-permeable seal member prior to sealing the storage cavity of the container with the seal member.
13. The method of claim 8 , wherein sealing the storage cavity of the container comprises sealing the container in a sealed gas-impermeable bag.
14. The method of claim 8 , wherein disposing the syringe in the storage cavity of the container comprises disposing the syringe in a first sub-cavity of the container, and disposing the absorbent in the storage cavity comprises disposing the absorbent in a second sub-cavity of the container, the first and second sub-cavities separated by a container wall.
15. The method of claim 8 , further comprising hydrating the absorbent in a water solution for a predetermined period of time prior to disposing the absorbent in the cavity.