Granted Patent
B2
US 12,398,178 · App. 17/269,939 · Granted Aug 26, 2025
Collections of peptides, peptide agents, and methods of use thereof
Inventors:
John Hanney McGee (Somerville, MA); Ty Matthew Thomson (Arlington, MA); Sebastian Christof Theodor Wahl (Zurich, CH); Gregory L. Verdine (Boston, MA); Raheleh Rezaei Araghi (Brookline, MA); Yue-Mei Zhang (Wellesley, MA); Mark Joseph Mulvihill (Sudbury, MA)
Assignee:
Parabilis Medicines, Inc.
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Abstract
The present disclosure provides powerful technologies for the development, production, characterization, and/or use of stapled peptide compositions. Among other things, the present disclosure provides strategies for defining amino acid sequences particularly amenable or useful for stapling, as well as technologies, reagents, and systems for developing, producing, characterizing, and/or using stapled peptides having such amino acid sequences.
Claims (14)
1. A collection of stapled peptides, each of which independently comprises ADPAXXXCXXAAXXCXXX (SEQ ID NO: 3), wherein:
each X is independently an amino acid residue;
the two cysteine residues are covalently linked with one another via a linker having the structure of —S-L s2 -S—, where each S is independently a sulfur atom of one of the two cysteine residues; and
L s2 is
2. The collection of claim 1 , wherein each individual stapled peptide in the collection is covalently bound to a phage particle.
3. The collection of claim 1 , wherein each stapled peptide of the collection is discretely associated with an identifier so that the amino acid sequence of the stapled peptide can be independently identified.
4. The collection of claim 3 , wherein the identifier comprises a nucleic acid sequence that encodes the amino acid sequence of the stapled peptide or a portion thereof.
5. The collection of claim 4 , wherein the amino acid sequence of the stapled peptide is expressed by a system that comprises the identifier.
6. The collection of claim 2 , wherein each stapled peptide of the collection is discretely associated with an identifier so that the amino acid sequence of the stapled peptide can be independently identified.
7. The collection of claim 6 , wherein the identifier comprises a nucleic acid sequence that encodes the amino acid sequence of the stapled peptide or a portion thereof.
8. The collection of claim 7 , wherein the amino acid sequence is expressed by a phage system that comprises the identifier.
9. The collection of claim 1 , wherein the stapled peptides of the collection are each fused to a phage protein.
10. The collection of claim 8 , wherein the stapled peptides of the collection are each fused to a phage protein.
11. The collection of claim 5 , wherein the stapled peptides of the collection are each fused to a phage protein.
Assignments (4)
CHANGE OF NAME
Recorded Jan 23, 2025
From: FOG PHARMACEUTICALS, INC.
To: PARABILIS MEDICINES, INC.
Reel/Frame 070001/0829 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 4, 2021
From: REZAEI ARAGHI, RAHELEH; ZHANG, YUE-MEI
To: FOG PHARMACEUTICALS, INC.
Reel/Frame 056444/0192 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 4, 2021
From: MCGEE, JOHN HANNEY; THOMSON, TY MATTHEW; WAHL, SEBASTIAN CHRISTOF THEODOR; VERDINE, GREGORY L.
To: FOG PHARMACEUTICALS, INC.
Reel/Frame 056444/0229 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 4, 2021
From: MULVIHILL, MARK JOSEPH
To: FOG PHARMACEUTICALS, INC.
Reel/Frame 056444/0249 →
Continuity (2)
Provisional Application
62719996
· Aug 20, 2018
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