Biological detection apparatuses, systems and methods
Biological detection apparatuses, systems and methods are provided. A biological detection apparatus may include a flexible substrate and a biosensor. The biosensor is provided on the flexible substrate and configured to obtain substance information of a living body.
1. A biological detection apparatus, comprising:
a flexible substrate; and
a biosensor provided on the flexible substrate and configured to obtain substance information of a living body,
wherein the biosensor comprises a microelectrode structure, the microelectrode structure comprising:
a first insulating layer;
a protrusion provided at a side of the first insulating layer;
an electrode layer conformally covering the first insulating layer and the protrusion;
a second insulating layer provided at a side of the electrode layer facing away from the first insulating layer, and provided with an opening through which the protrusion protrudes;
a first sensitive functional layer at least covering an area of the electrode layer corresponding to an entirety of the protrusion;
an auxiliary layer at least covering an area of the first sensitive functional layer corresponding to an entirety of the protrusion except for a first through-hole exposing only part of the first sensitive functional layer, wherein the first through-hole is provided in an area of the auxiliary layer corresponding to a top end of the protrusion; and
a second sensitive functional layer entirely covering the auxiliary layer and filling the first through-hole so as to be in contact with the first sensitive functional layer,
wherein the electrode layer is sandwiched between the first and second insulating layers corresponding to an area where there are no protrusions, and the auxiliary layer is sandwiched between the first sensitive functional layer and the second sensitive functional layer.
2. The biological detection apparatus according to claim 1 , further comprising:
a communication module, provided at a side of the flexible substrate and connected with the biosensor, and configured to send the substance information to a terminal device; and
an analog-to-digital converter, provided at the side of the flexible substrate and connected with the biosensor and the communication module, and configured to perform an analog-to-digital conversion on the substance information and send the converted substance information to the communication module.
3. The biological detection apparatus according to claim 1 , wherein the biosensor is provided at a side of the flexible substrate facing the living body and located within a boundary of the flexible substrate.
4. The biological detection apparatus according to claim 1 , wherein at least a part of the biosensor is located outside a boundary of the flexible substrate.
5. The biological detection apparatus according to claim 1 , further comprising at least one of:
a temperature sensor, provided at a side of the flexible substrate facing the living body and configured to detect temperature information of the living body; or
a heart rate sensor, provided at the side of the flexible substrate facing the living body and configured to detect heart rate information of the living body.
6. The biological detection apparatus according to claim 1 , further comprising:
a power supply module, provided at a side of the flexible substrate facing away from the living body and connected with the biosensor to supply power to the biosensor.
7. The biological detection apparatus according to claim 1 , wherein an angle between a side surface and a bottom surface of the protrusion is an acute angle.
8. The biological detection apparatus according to claim 7 , wherein the protrusion has a tapered shape.
9. The biological detection apparatus according to claim 1 ,
wherein the protrusion has a maximum width of less than or equal to 10 μm in a direction parallel to the first insulating layer, and
the protrusion is made of an insulating material.
10. The biological detection apparatus according to claim 1 , wherein the protrusion and the first insulating layer are structurally integrated.
11. The biological detection apparatus according to claim 1 , wherein the electrode layer comprises one or more electrode regions separated from each other, and the first insulating layer is provided with a plurality of protrusions correspondingly to each of the electrode regions.
12. The biological detection apparatus according to claim 1 , wherein the electrode layer comprises a reference electrode region and one or more working electrode regions; or
the electrode layer comprises a reference electrode region, a counter electrode region and one or more working electrode regions.
13. The biological detection apparatus according to claim 1 , wherein the electrode layer comprises one or more electrode regions separated from each other, and a distance between adjacent two of the electrode regions is 0.5 cm-2 cm.
14. The biological detection apparatus according to claim 1 , wherein a distance between the auxiliary layer and the electrode layer is less than or equal to 100 μm.
15. The biological detection apparatus according to claim 1 , wherein the first sensitive functional layer comprises a sodium ion sensitive functional layer, a potassium ion sensitive functional layer, a calcium ion sensitive functional layer, a hydrogen ion sensitive functional layer or a chloride ion sensitive functional layer.
16. The biological detection apparatus according to claim 1 , wherein the biosensor is configured to detect the substance information in sweat of the living body.
17. A biological detection system, comprising a biological detection apparatus, wherein the biological detection apparatus comprises:
a flexible substrate; and
a biosensor provided on the flexible substrate and configured to obtain substance information of a living body,
wherein the biosensor comprises a microelectrode structure, the microelectrode structure comprising:
a first insulating layer;
a protrusion provided at a side of the first insulating layer;
an electrode layer conformally covering the first insulating layer and the protrusion; and
a second insulating layer provided at a side of the electrode layer facing away from the first insulating layer, and provided with an opening through which the protrusion protrudes;
a first sensitive functional layer at least covering an area of the electrode layer corresponding to an entirety of the protrusion;
an auxiliary layer at least covering an area of the first sensitive functional layer corresponding to an entirety of the protrusion except for a first through-hole exposing only part of the first sensitive functional layer, wherein the first through-hole is provided in an area of the auxiliary layer corresponding to a top end of the protrusion;
a second sensitive functional layer entirely covering the auxiliary layer and filling the first through-hole so as to be in contact with the first sensitive functional layer,
wherein the electrode layer is sandwiched between the first and second insulating layers corresponding to an area where there are no protrusions, and the auxiliary layer is sandwiched between the first sensitive functional layer and the second sensitive functional layer.
18. A biological detection method, comprising:
obtaining first substance information of the living body by using the biosensor of the biological detection apparatus according to claim 1 ; and
replacing the biosensor of the biological detection apparatus to obtain second substance information of the living body.
19. The biological detection method according to claim 18 , wherein the first substance information or the second substance information comprises a sodium ion concentration, a potassium ion concentration, a calcium ion concentration, a hydrogen ion concentration, or a chloride ion concentration.