IP Library › Granted Patent US 12,404,279

Granted Patent B2

US 12,404,279 · App. 18/145,618 · Granted Sep 2, 2025

Deubiquitinase inhibitors and methods of use thereof

Inventors: Jacek Chrzanowski (Łódź, PL); Julita Nowicka (Wola Grzymkowa, PL); Łukasz Joachimiak (Lodz, PL); Robert Koralewski (Lodz, PL); Sylwia Olejniczak (Lodz, PL); Marzena Mazur (Lodz, PL); Bartlomiej Borek (Lodz, PL); Anna Gzik (Wartkowice, PL); Krzysztof Matyszewski (Lodz, PL); Sylwia Ciastek-Iskrzycka (Łódź, PL); Piotr Niedziejko (Warsaw, PL); Angelika Muchowicz (Warsaw, PL); Zbigniew Zasłona (Warsaw, PL); Roman Błaszczyk (Lodz, PL); Jacek Olczak (Łódź, PL); Adam Golebiowski (Madison, CT)

Assignee: Molecure S.A.

C07D495/04 A61P35/00 C07D471/04 C07D491/048 C07D513/04 C07D519/00 C07B2200/07

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Patent No.: US 12,404,279
App. No.: 18/145,618
Granted: Sep 2, 2025
Kind: B2

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Abstract

The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.

Claims (147)

1. A compound of structural Formula (Ia):

wherein:

R 2 is selected from hydrogen, methyl, ethyl, chloro, —C≡N, and —CF 3 ;

L 3 represents a single bond, —CH 2 —, —C(═O)—, —NH—, or —NH—C(═O)—; and

R 3 is selected from (4-6) membered heterocycloalkyl containing 1 to 2 nitrogen heteroatoms or 1 nitrogen heteroatom and 1 oxygen heteroatom, and optionally substituted with 1 or 2 substituents selected from fluoro, methyl, ethyl, amino, methylamino, dimethylamino, ethylamino, isopropylamino, hydroxy, oxo, aminomethyl, 1-aminoethyl, (isopropylamino)methyl, ureido, alanylamino, valylamino, fluoromethyl, difluoromethyl, trifluoromethyl, and 2,2,2-trifluoroacetyl;

or a tautomer, stereoisomer, a racemic or scalemic mixture of stereoisomers, a pharmaceutically acceptable salt, ester, solvate, or polymorph thereof.

2. The compound according to claim 1 , wherein the compound is:

6,6-dimethyl-3-((7-(4-methyl-3-(pyrrolidin-3-ylamino)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-(pyrrolidin-3-ylamino)picolinonitrile;

5-(azetidin-3-ylamino)-6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methylpicolinonitrile;

N-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-6-(trifluoromethyl)pyridin-3-yl)azetidine-3-carboxamide;

6,6-dimethyl-3-((7-(4-methyl-3-(piperazin-2-ylmethyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((1H-1,2,4-triazol-1-yl)methyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((3,6-dioxopiperazin-2-yl)methyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((3-oxomorpholino)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((2-oxopyrrolidin-1-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((2-oxopiperazin-1-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((4-methyl-2-oxopiperazin-1-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-5-(3-(dimethylamino)azetidine-1-carbonyl)-4-methylpicolinonitrile;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-5-((S)-3-(dimethylamino)pyrrolidine-1-carbonyl)-4-methylpicolinonitrile;

6,6-dimethyl-3-((7-(4-methyl-3-(piperazine-1-carbonyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(piperazin-1-ylmethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-((S)-2-methylpiperazine-1-carbonyl)picolinonitrile;

6,6-dimethyl-3-((7-(4-methyl-3-(morpholine-4-carbonyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3,3-difluoropyrrolidine-1-carbonyl)-4-methylpyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3,3-difluoroazetidine-1-carbonyl)-4-methylpyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

5-(3,3-difluoroazetidine-1-carbonyl)-6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methylpicolinonitrile;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-5-((S)-2,4-dimethylpiperazine-1-carbonyl)-4-methylpicolinonitrile;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-5-(3,3-dimethylpiperazine-1-carbonyl)-4-methylpicolinonitrile;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-((R)-2-methylpiperazine-1-carbonyl)picolinonitrile;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-(piperazine-1-carbonyl)picolinonitrile;

N-(azetidin-3-yl)-6-cyano-2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methylnicotinamide;

6-cyano-N-(3,3-difluorocyclobutyl)-2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methylnicotinamide;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-(morpholine-4-carbonyl)picolinonitrile;

5-(3,3-difluoropyrrolidine-1-carbonyl) 2 -((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methylpicolinonitrile;

3-((7-(3-((S)-3-(ethylamino)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-(isopropylamino)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(piperazine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((S)-3-(methylamino)pyrrolidine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((S)-2-methylpiperazine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-2,4-dimethylpiperazine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(4-methylpiperazine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-aminopyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-(dimethylamino)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3,3-difluoropyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(morpholine-4-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3,3-difluoroazetidine-1-carbonyl)-4,6-dimethylpyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(2-methyl-3-(((R)-pyrrolidin-3-yl)methyl)-6-(trifluoromethyl)pyridin-4-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(2-methyl-3-(((S)-pyrrolidin-3-yl)methyl)-6-(trifluoromethyl)pyridin-4-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(morpholin-2-ylmethyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-5-(morpholin-2-ylmethyl)picolinonitrile;

6,6-dimethyl-3-((7-(4-methyl-3-(((S)-morpholin-2-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(((R)-morpholin-2-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(((S)-4-methylmorpholin-2-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(((R)-4-methylmorpholin-2-yl)methyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-(difluoromethyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-(fluoromethyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((3S,4S)-3-amino-4-methylpyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((3S,4R)-3-amino-4-methylpyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

(2S)-2-amino-N-((3S)-1-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-6-(trifluoromethyl)nicotinoyl)pyrrolidin-3-yl)-3-methylbutanamide;

(2S)-2-amino-N-((3S)-1-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-6-(trifluoromethyl)nicotinoyl)pyrrolidin-3-yl)propanamide;

3-((7-(3-(4-aminopiperidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-hydroxypyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((S)-3-fluoropyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((R)-3-(aminomethyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((3R,4R)-3-amino-4-fluoropyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(6-chloro-4-methyl-3-(2-oxotetrahydropyrimidin-1(2H)-yl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(azetidin-3-ylamino)-6-chloro-4-methylpyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(6-chloro-3-((3,3-difluorocyclobutyl)amino)-4-methylpyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(4,6-dimethyl-3-(pyrrolidin-3-ylamino)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(6-chloro-4-methyl-3-(pyrrolidin-3-ylamino)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(6-chloro-4-methyl-3-(piperidin-4-ylamino)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(piperidin-4-ylamino)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(6-chloro-4-methyl-3-(piperidin-3-ylamino)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-(piperidin-3-ylamino)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

N-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4,6-dimethylpyridin-3-yl)azetidine-3-carboxamide;

N-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4,6-dimethylpyridin-3-yl)piperidine-4-carboxamide;

3-((7-(6-chloro-4-methyl-3-(piperazine-1-carbonyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

1-((3S)-1-(2-(2-((6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl)thieno[3,2-b]pyridin-7-yl)-4-methyl-6-(trifluoromethyl)nicotinoyl)pyrrolidin-3-yl)urea;

3-((7-(3-(3-amino-3-methylpyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((3S)-3-(1-aminoethyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3-(aminomethyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(3-((isopropylamino)methyl)pyrrolidine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((2S,6S)-2,6-dimethylpiperazine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-((2R,6R)-2,6-dimethylpiperazine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

3-((7-(3-(4-ethylpiperazine-1-carbonyl)-4-methyl-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;

6,6-dimethyl-3-((7-(4-methyl-3-((S)-3-(methylamino)piperidine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione;

or a tautomer, stereoisomer, a racemic or scalemic mixture of stereoisomers, a pharmaceutically acceptable salt, ester, solvate, or polymorph thereof.

3. The compound according to claim 2 , wherein the compound is: