IP Library Granted Patent US 12,406,412
Granted Patent B2
US 12,406,412 · App. 18/102,834 · Granted Sep 2, 2025

System and method for deep learning-based chemical shift artifact mitigation of non-Cartesian magnetic resonance imaging data

Inventors: Sagar Mandava (Atlanta, GA); Robert Marc Lebel (Calgary, CA); Michael Carl (San Marcos, CA); Florian Wiesinger (Freising, DE)
Assignee: GE Precision Healthcare LLC
G06T11/008G01R33/4824G01R33/5608G06N3/08G06T2210/41
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,406,412
App. No.
18/102,834
Granted
Sep 2, 2025
Kind
B2
Abstract

A computer-implemented method for generating a chemical shift artifact corrected reconstructed image from magnetic resonance imaging (MRI) data includes inputting into a trained deep neural network an image generated from the MRI data acquired during a non-Cartesian MRI scan of a subject. The method also includes utilizing the trained deep neural network to generate the chemical shift artifact corrected reconstructed image from the image, wherein the trained deep neural network was trained utilizing a tissue mixing model that models interactions between different tissue types to mitigate chemical shift artifacts. The method further includes outputting from the trained deep neural network the chemical shift artifact corrected reconstructed image.

Claims (28)

1. A computer-implemented method for generating a chemical shift artifact corrected reconstructed image from magnetic resonance imaging (MRI) data, comprising:

inputting into a trained deep neural network an image generated from the MRI data acquired during a non-Cartesian MRI scan of a subject;

utilizing the trained deep neural network to generate the chemical shift artifact corrected reconstructed image from the image, wherein the trained deep neural network was trained utilizing a tissue mixing model that models interactions between different tissue types to mitigate chemical shift artifacts, and wherein the tissue mixing model comprises a partial volume map for approximating a respective fraction of the different tissue types in each voxel of the image; and

outputting from the trained deep neural network the chemical shift artifact corrected reconstructed image.

2. The computer-implemented method of claim 1 , wherein the MRI data is acquired at a lower receiver bandwidth, and the chemical shift artifact corrected reconstructed image appears as generated from MRI data acquired at a higher receiver bandwidth, wherein the higher receiver bandwidth is greater than the lower receiver bandwidth.

3. The computer-implemented method of claim 1 , further comprising training a neural network using supervised learning to generate the trained deep neural network, wherein training data used for the supervised learning comprises original images without chemical shift artifacts and corresponding images with chemical shift artifacts retrospectively generated from the original images, wherein the original images function as a ground truth.

4. The computer-implemented method of claim 1 , wherein the tissue mixing model is configured to simulate phase accrual of the different tissue types with known chemical shift evolution.

5. The computer-implemented method of claim 1 , further comprising receiving an input of a user selection of either fully removing or partially removing a chemical shift artifact in the image, wherein, when the input of the user selection is for fully removing the chemical shift artifact, the chemical shift artifact is fully removed from the chemical shift artifact corrected reconstructed image, and wherein, when the input of the user selection is for partially removing the chemical shift artifact, the chemical shift artifact is partially removed from the chemical shift artifact corrected reconstructed image.

6. The computer-implemented method of claim 1 , wherein the image is the only image inputted into the trained deep neural network to generate the chemical shift artifact corrected reconstructed image.

7. The computer-implemented method of claim 1 , wherein the non-Cartesian MRI scan comprises an on-resonance scan.

8. The computer-implemented method of claim 1 , wherein the non-Cartesian MRI scan comprises an off-resonance scan.

9. The computer-implemented method of claim 1 , further comprising inputting physics-based information into the trained deep neural network, wherein the trained deep neural network utilizes the physics-based information to guide correction in generating the chemical shift artifact corrected reconstructed image.

10. The computer-implemented method of claim 9 , wherein the physics-based information comprises one or more MRI images at different frequencies generated from the original MRI data.

11. The computer-implemented method of claim 9 , wherein the physics-based information comprises a map of a primary magnetic field of an MRI system utilized to acquire the MRI data.

12. The computer-implemented method of claim 9 , wherein the physics-based information comprises scalar information.

13. The computer-implemented method of claim 1 , wherein the image and the chemical shift artifact corrected reconstructed image are two-dimensional images.

14. The computer-implemented method of claim 1 , wherein the image and the chemical shift artifact corrected reconstructed image are three-dimensional images.

15. A non-transitory computer-readable medium, the computer-readable medium comprising processor-executable code that when executed by a processor, causes the processor to:

input into a trained deep neural network an image generated from magnetic resonance imaging (MRI) data acquired during a non-Cartesian MRI scan of a subject;

utilize the trained deep neural network to generate a chemical shift artifact corrected data from the image, wherein the trained deep neural network was trained utilizing a tissue mixing model that models interactions between different tissue types to mitigate chemical shift artifacts, and wherein the tissue mixing model comprises a partial volume map for approximating a respective fraction of the different tissue types in each voxel of the image; and

output from the trained deep neural network the chemical shift artifact corrected data.

16. A deep learning-based chemical shift artifact correction system for generating a chemical shift artifact corrected data from magnetic resonance imaging (MRI) data, comprising:

a memory encoding processor-executable routines;

a processor configured to access the memory and to execute the processor-executable routines, wherein the routines, when executed by the processor, cause the processor to:

input into a trained deep neural network an image generated from the MRI data acquired during a non-Cartesian MRI scan of a subject;

utilize the trained deep neural network to generate the chemical shift artifact corrected data from the image, wherein the trained deep neural network was trained utilizing a tissue mixing model that models interactions between different tissue types to mitigate chemical shift artifacts, and wherein the tissue mixing model comprises a partial volume map for approximating a respective fraction of the different tissue types in each voxel of the image; and

output from the trained deep neural network the chemical shift artifact corrected data.

17. The system of claim 16 , wherein the routines, when executed by the processor, cause the processor to input physics-based information into the trained deep neural network, wherein the trained deep neural network is configured to utilize the physics-based information to guide correction in generating the chemical shift artifact corrected data.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2023
From: MANDAVA, SAGAR; LEBEL, ROBERT MARC; WIESINGER, FLORIAN; CARL, MICHAEL
To: GE PRECISION HEALTHCARE LLC
Reel/Frame 062525/0391 →
Continuity (1)
Related Publication 20240257414A1 · Aug 1, 2024
References Cited (14)
US 10635943B1 · Lebel et al. · 2020 [cited by applicant]
US 10969451B1 · Wiesinger et al. · 2021 [cited by applicant]
US 11257191B2 · Litwiller et al. · 2022 [cited by applicant]
US 11341616B2 · Wang et al. · 2022 [cited by applicant]
US 11346912B2 · Guidon et al. · 2022 [cited by applicant]
US 20190277935A1 · Zeng et al. · 2019 [cited by applicant]
US 20200126190A1 · Lebel · 2020 [cited by applicant]
CN 110095742A · 2019 [cited by examiner]
WO 2021197955 · 2021 [cited by applicant]
Haskell et al., “Off-resonance artifact correction for MRI: A review”, Nov. 2022 (Year: 2022). [cited by examiner]
Zeng et al., “Deep Residual Network for Off-Resonance Artifact Correction With Application to Pediatric Body MRA With 3D Cones,” Magnetic Resonance in Medicine, 2019, Wiley Online library, vol. 82, 14 pgs. [cited by applicant]
Lim et al., “Deblurring for Spiral Real-Time MRI Using Convolutional Neural Networks,” Magnetic Resonance in Medicine, 2020, Wiley Online library, vol. 84, 15 pgs. [cited by applicant]
Chen et al., “Ultrafast Water—Fat Separation Using Deep Learning—Based Single-Shot MRI,” Magnetic Resonance in Medicine, 2022, Wiley Online library, vol. 87, 16 pgs. [cited by applicant]
Li et al., “Accelerating Multi-Echo Chemical Shift Encoded Water—Fat MRI Using Model-Guided Deep Learning.” Magnetic Resonance in Medicine, 2022, Wiley Online library, vol. 88, 15 pgs. [cited by applicant]