IP Library Granted Patent US 12,410,077
Granted Patent B1
US 12,410,077 · App. 18/849,873 · Granted Sep 9, 2025

Methods, systems, and compositions for oxidation of a substrate

Inventor: Matthew Mills (Glenshaw, PA)
Assignee: SUDOC, LLC
C02F1/4672C02F1/46104C02F2101/308C02F2101/34C02F2101/38C02F2103/343C02F2305/02
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Quick Facts
Patent No.
US 12,410,077
App. No.
18/849,873
Granted
Sep 9, 2025
Kind
B1
Abstract

Methods, systems, and compositions for oxidation are provided. The method comprises combining a macrocyclic ligand and metal complex catalyst, an electrolyte, the substrate, and water to form an aqueous composition. The method comprises applying an electrical voltage to the aqueous composition and oxidizing the substrate in the presence of the catalyst.

Claims (25)

1. A method for oxidation of a substrate, the method comprising:

combining a macrocyclic ligand and metal complex catalyst, an electrolyte, the substrate, and water to form an aqueous composition; and

applying an electrical voltage to the aqueous composition and oxidizing the substrate in the presence of the catalyst, wherein the catalyst comprises at least one of the following structures:

2. The method of claim 1 , wherein the electrolyte is added in an amount to achieve a conductivity in the aqueous composition in a range of 0.1 μS/cm to 100 mS/cm.

3. The method of claim 1 , wherein the electrolyte is added in an amount to achieve a conductivity in the aqueous composition in a range of 50 μS/cm to 100 μS/cm.

4. The method of claim 1 , wherein the electrolyte comprises a salt.

5. The method of claim 1 , wherein the electrolyte comprises a halogen salt, a sulfate salt, a phosphate salt, a nitrate salt, and/or a carbonate salt.

6. The method of claim 1 , wherein the electrolyte comprises sodium chloride, sodium sulfate, sodium phosphate, or a combination thereof.

7. The method of claim 1 , wherein the substrate comprises organic compounds.

8. The method of claim 1 , wherein the substrate comprises inorganic compounds.

9. The method of claim 1 , wherein the water is added in an amount to achieve a concentration in the aqueous composition of at least 50% by weight water based on a total weight of the aqueous composition.

10. The method of claim 1 , wherein the catalyst is added in an amount to achieve a concentration in the aqueous composition in a range of 10 nM to 100 μM of the catalyst.

11. The method of claim 1 , wherein the catalyst is added in an amount to achieve a concentration in the aqueous composition in a range of 1 μM to 10 μM of the catalyst.

12. The method of claim 1 , further comprising adding an additional reagent to the aqueous composition, wherein the additional reagent is selected from the group consisting of a wetting agent, a surfactant, denaturing agent, co-solvent, and a buffer.

13. The method of claim 1 , wherein the aqueous composition is oxidant free prior to applying the voltage.

14. The method of claim 1 , wherein during the oxidation, a pH of the aqueous composition is in a range of 4 to 13.

15. The method of claim 1 , wherein during the oxidation, a pH of the aqueous composition is in a range of 6 to 8.

16. The method of claim 1 , wherein during the oxidation, the aqueous composition is at a temperature in a range of 0° C. to 95° C.

17. The method of claim 1 , wherein the electrical voltage is applied to the aqueous composition to achieve a current density in the aqueous composition in a range of 0 to 100 mA/cm 2 .

18. The method of claim 1 , wherein the electrical voltage is applied to the aqueous composition to achieve a current density in the aqueous composition in a range of 0 mA/cm 2 to 500 mA/cm 2 .

19. The method of claim 1 , wherein the electrical voltage is applied to the aqueous composition to achieve a current density in the aqueous composition in a range of 1 mA/cm 2 to 10 mA/cm 2 .

20. The method of claim 1 , further comprising introducing the aqueous composition into an electrolysis cell comprising an anode and a cathode, wherein the aqueous composition is disposed in contact with the anode and the cathode, and the electrical voltage is applied across the anode and cathode such that the substrate is oxidized in the presence of the catalyst.

21. A system for oxidation of a substrate, the system comprising:

an electrolysis cell comprising an anode and a cathode; and

a catalyst comprising at least one of the following structures:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2025
From: MILLS, MATTHEW
To: SUDOC, LLC
Reel/Frame 071510/0903 →
Continuity (1)
Provisional Application 63508701 · Jun 16, 2023
References Cited (17)
US 5952542A · Steele · 1999 [cited by examiner]
US 6054580A · Collins · 2000 [cited by examiner]
US 10926248B2 · Collins · 2021 [cited by examiner]
US 11465136B2 · Berry et al. · 2022 [cited by applicant]
US 20020050451A1 · Ford et al. · 2002 [cited by applicant]
US 20110094043A1 · Ghosh et al. · 2011 [cited by applicant]
US 20200321630A1 · Basheer · 2020 [cited by examiner]
US 20210086171A1 · Collins · 2021 [cited by examiner]
US 20240166538A1 · Madsen · 2024 [cited by examiner]
EP 2064367A1 · 2009 [cited by applicant]
WO 2008034634A1 · 2008 [cited by applicant]
English translation of CN 112624274 (Year: 2021). [cited by examiner]
Lin et al, First-Row Transition-Metal Complexes with Tetra-Amido Macrocyclic Ligands for Water and C(sp3)—H Bond Oxidation: Performance Benchmarking Using Free Energy Relationships, ChemCatChem 2024, 16, e202301375. htt… [cited by examiner]
Warner, Genoa R., et al. “Bioinspired, multidisciplinary, iterative catalyst design creates the highest performance peroxidase mimics and the field of sustainable ultradilute oxidation catalysis (SUDOC).” ACS Catalysis … [cited by examiner]
Beach, Evan S., et al. “Activation of hydrogen peroxide by an Fe-TAML complex in strongly alkaline aqueous solution: homogeneous oxidation catalysis with industrial significance.” Industrial & engineering chemistry rese… [cited by examiner]
Ellis, W. Chadwick, et al. “Fast water oxidation using iron.” Journal of the American Chemical Society 132.32 (2010): 10990-10991 (Year: 2010). [cited by examiner]
International Search Report and Written Opinion of the International Searching Authority for International Application No. PCT/US24/27594 mailed Jul. 31, 2024. [cited by applicant]