IP Library › Granted Patent US 12,411,103
Granted Patent B2
US 12,411,103 · App. 17/853,991 · Granted Sep 9, 2025

Electrode, method for manufacturing electrode, ion sensor, in-vivo component measuring device, and in-vivo component measuring method

Inventors: Kenichi Uchiyama (Kobe, JP); Junko Kojima (Kobe, JP)
Assignee: SYSMEX CORPORATION
G01N27/333G01N27/301G01N27/406
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Quick Facts
Patent No.
US 12,411,103
App. No.
17/853,991
Granted
Sep 9, 2025
Kind
B2
Abstract

An electrode with higher potential stability for repeated use and/or long-term use in an ion sensor is provided. The electrode includes an internal solid layer containing a metal oxide and a solid electrolyte and an electrode material.

Claims (63)

1. An ion sensor comprising:

an insulating substrate;

an ion-selective electrode on the insulating substrate; and

a reference electrode on the insulating substrate, wherein the ion-selective electrode comprises:

a first internal solid layer containing metal oxide and solid electrolyte;

a first electrode material; and

an ion-selective membrane, wherein

the first internal solid layer is sandwiched between the first electrode material and the ion-selective membrane in a thickness direction of the first internal solid layer,

the ion-selective membrane comprises a multi-layer structure including a plurality of layers having the same or different compositions from each other,

the first electrode material comprises a multi-layer structure including a plurality of layers having different compositions from each other,

the first internal solid layer is provided to cover a side surface of the first electrode material,

the ion-selective membrane is provided to cover a side surface of the first internal solid layer so as not to expose the first internal solid layer,

the reference electrode comprises:

a second internal solid layer containing metal oxide and solid electrolyte;

a second electrode material; and

a salt bridge layer, wherein

the second internal solid layer is sandwiched between the second electrode material and the salt bridge layer in a thickness direction of the second internal solid layer,

the salt bridge layer comprises a multi-layer structure including a plurality of layers having different compositions from each other, and

the second electrode material comprises a multi-layer structure including a plurality of layers having different compositions from each other.

2. The ion sensor according to claim 1 , wherein

the solid electrolyte of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is an ion conductive ceramics.

3. The ion sensor according to claim 1 , wherein

the solid electrolyte of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is a potassium ion conductive ceramics.

4. The ion sensor according to claim 1 , wherein

the solid electrolyte of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is β″-alumina or β-alumina.

5. The ion sensor according to claim 1 , wherein

the metal oxide of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is an ion-electron conductor.

6. The ion sensor according to claim 1 , wherein

the metal oxide of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is an ion-electron conductor for potassium ions.

7. The ion sensor according to claim 6 , wherein

the metal oxide of the at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is MxMnO 2 , wherein M indicates K, and x indicates an arbitrary positive number.

8. The ion sensor according to claim 7 , wherein

the x is 0.2 to 0.5.

9. The ion sensor according to claim 1 , wherein

the solid electrolyte and the metal oxide of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer are in a form of particles.

10. The ion sensor according to claim 9 , wherein

the average particle size of the solid electrolyte of the at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is smaller than the average particle size of the metal oxide of the at least one selected from the group consisting of the first internal solid layer and the second internal solid layer.

11. The ion sensor according to claim 1 , wherein

the mass ratio of the metal oxide to the solid electrolyte in at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is from 2:1 to 1:2.

12. The ion sensor according to claim 1 , wherein

at least one selected from the group consisting of the first internal solid layer and the second internal solid layer contains a binder and a conductive agent.

13. The ion sensor according to claim 12 , wherein the binder is at least one type selected from a group consisting of:

(A) polyvinylidene fluoride;

(B) a mixture containing styrene-butadiene latex and carboxymethyl cellulose;

(C) a mixture containing polyamide, polyimide, and carbodiimide;

(D) polytetrafluoroethylene; and

(E) acrylic emulsion.

14. The ion sensor according to claim 12 , wherein

the conductive agent is at least one type selected from the group consisting of carbon black, acetylene black, ketjen black, carbon nanotube, graphene, carbon powder, and graphite powder.

15. The ion sensor according to claim 1 , wherein

the first internal solid layer is arranged directly on the first electrode material of the ion-selective electrode, and the second internal solid layer is arranged directly on the second electrode material of the reference electrode.

16. The ion sensor according to claim 1 , wherein

the ion-selective membrane contains an ionophore.

17. The ion sensor according to claim 1 , wherein

the first internal solid layer containing the metal oxide and the solid electrolyte is electrostatically coated on the first electrode material, or

the second internal solid layer containing the metal oxide and the solid electrolyte is electrostatically coated on the second electrode material.

18. The ion sensor according to claim 1 , wherein

the solid electrolyte of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is a sodium ion conductive ceramic.

19. The ion sensor according to claim 1 , wherein

the metal oxide of at least one selected from the group consisting of the first internal solid layer and the second internal solid layer is an ion-electron conductor for sodium ions.

20. The ion sensor according to claim 1 , wherein

the first internal solid layer comprises a multi-layer structure including a plurality of layers having different compositions from each other, and

the second internal solid layer comprises a multi-layer structure including a plurality of layers having different compositions from each other.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2022
From: UCHIYAMA, KENICHI; KOJIMA, JUNKO
To: SYSMEX CORPORATION
Reel/Frame 060365/0286 →
Priority Claims (1)
JP 2020-003117 · Jan 10, 2020 · national
Continuity (2)
Continuation PCTJP2020048407 · Dec 24, 2020
Related Publication 20220334077A1 · Oct 20, 2022
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