IP Library Granted Patent US 12,412,245
Granted Patent B2
US 12,412,245 · App. 18/082,448 · Granted Sep 9, 2025

Method and system for axial motion correction

Inventor: Homayoun Bagherinia (Oakland, CA)
Assignee: CARL ZEISS MEDITEC, INC.
G06T5/10A61B3/1005A61B3/102A61B3/12G06T5/50G06T7/20G06T2207/10101G06T2207/30041
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,412,245
App. No.
18/082,448
Granted
Sep 9, 2025
Kind
B2
Abstract

A method and system for correcting axial motion in optical coherence tomography (OCT) data is provided. The method includes collecting, by a processor disposed of in an OCT device, a volume scan of an eye; segmenting a first retinal layer within the volume scan; applying an algorithm for periodic pattern removal of OCT data in the first retinal layer by determining a model of a Fourier transform applicable to a segment of the first retinal layer; and removing transform frequencies associated with the OCT data using the model of the Fourier transform; determining a measure of an amount of axial motion in accordance with a difference of an amount of OCT data captured on a surface of the first retinal layer before and after application of the algorithm for periodic pattern removal; and correcting, the amount of axial motion in the OCT data of the first retinal layer.

Claims (29)

1. A method for correcting for axial motion in optical coherence tomography (OCT) data, comprising:

collecting, by a processor disposed of in an OCT device, a volume scan of an eye;

segmenting, by the processor, a first retinal layer within the volume scan;

applying, by the processor, an algorithm for periodic pattern removal of OCT data in the first retinal layer by:

determining a model of a Fourier transform applicable to a segment of the first retinal layer; and

removing one or more transform frequencies associated with the OCT data using the model of the Fourier transform for the periodic pattern removal while leaving unchanged other frequencies associated with OCT data in the first retinal layer;

determining, by the processor, a measure of an amount of axial motion in accordance with a difference in an amount of OCT data captured on a surface of the first retinal layer before and after application of the algorithm for periodic pattern removal; and

correcting, by the processor, the amount of axial motion in the OCT data of the first retinal layer.

2. The method of claim 1 , wherein the periodic pattern removal further comprises recovering by the processor of a motion-corrected version of the first retinal layer by applying an inverse Fourier transfer after removal of the frequencies associated with the periodic pattern removal.

3. The method of claim 1 , further comprising:

correcting, by the processor, the amount of axial motion, in a second retinal layer.

4. The method of claim 3 , wherein the first retina layer comprises an internal limiting membrane (ILM) layer, and the second retinal layer comprises retinal pigment epithelium (RPE) layer.

5. The method of claim 1 , further comprising: defining, by the processor, a retinal thickness map in accordance with a difference in the amount of OCT data contained on the surface of the ILM layer and the RPE layer after application of an axial motion correction to the ILM layer and the RPE layer.

6. The method of claim 1 , wherein the model for periodic pattern removal is determined by an integral number of oscillations across the Fourier transform.

7. The method of claim 1 , wherein the first retinal layer at least comprises a two-dimensional retinal layer.

8. A system for correcting axial motion error in optical coherence tomography (OCT) data, comprising:

an OCT device configured to collect a volume scan of an eye; and

a processor disposed of in the OCT device configured to:

apply an algorithm for periodic pattern removal of OCT data in a first retinal layer to:

determine a model of a Fourier transform applicable to a segment of the first retinal layer; and

remove one or more transform frequencies associated with the OCT data using the model of the Fourier transform for the periodic pattern removal while leaving unchanged other frequencies associated with OCT data in the first retinal layer;

determine a measure of an amount of axial motion in accordance with a difference in an amount of OCT data captured on a surface of the first retinal layer before and after application of the algorithm for periodic pattern removal; and

correct the amount of axial motion in the OCT data of the first retinal layer.

9. The system of claim 8 , wherein the processor is configured to: correct the amount of axial motion in a second retinal layer.

10. The system of claim 9 , wherein the first retinal layer is positioned higher than the second retinal layer within a retina of the eye.

11. The system of claim 10 , wherein the first retinal layer comprises an internal limiting membrane (ILM) layer, and the second retinal layer comprises a retinal pigment epithelium (RPE) layer.

12. The system of claim 11 , wherein the processor is configured to define a retinal thickness map in accordance with a difference in the amount of OCT data contained on the surface of the ILM layer and the RPE layer after application of an axial motion correction to the ILM layer and the RPE layer.

13. The system of claim 12 , wherein the model for periodic pattern removal is determined by an integral number of oscillations across the Fourier transform.

14. The system of claim 13 , wherein the first retinal layer at least comprises a two-dimensional retinal layer.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2023
From: BAGHERINIA, HOMAYOUN
To: CARL ZEISS MEDITEC, INC.
Reel/Frame 062488/0402 →
Continuity (2)
Provisional Application 63291246 · Dec 17, 2021
Related Publication 20230196525A1 · Jun 22, 2023
References Cited (50)
US 6549801B1 · Chen et al. · 2003 [cited by applicant]
US 7301644B2 · Knighton et al. · 2007 [cited by applicant]
US 9332902B2 · Tumlinson et al. · 2016 [cited by applicant]
US 9414065B2 · Moriyoshi · 2016 [cited by examiner]
US 9456746B2 · Bublitz et al. · 2016 [cited by applicant]
US 10952603B2 · Bagherinia · 2021 [cited by applicant]
US 20050171438A1 · Chen et al. · 2005 [cited by applicant]
US 20070291277A1 · Everett et al. · 2007 [cited by applicant]
US 20100027857A1 · Wang · 2010 [cited by applicant]
US 20120249956A1 · Narasimha-Iyer et al. · 2012 [cited by applicant]
US 20120277579A1 · Sharma et al. · 2012 [cited by applicant]
US 20120307014A1 · Wang · 2012 [cited by applicant]
US 20130100456A1 · Yu et al. · 2013 [cited by applicant]
US 20130163003A1 · Massow et al. · 2013 [cited by applicant]
US 20140268038A1 · Schmoll · 2014 [cited by applicant]
US 20150131050A1 · Bublitz et al. · 2015 [cited by applicant]
US 20160000320A1 · Sharma et al. · 2016 [cited by applicant]
US 20160166144A1 · Izatt et al. · 2016 [cited by applicant]
US 20180014725A1 · Bagherinia · 2018 [cited by examiner]
US 20220142471A1 · Ashok · 2022 [cited by examiner]
WO 2012059236 · 2012 [cited by applicant]
WO 2016124644 · 2016 [cited by applicant]
Hillmann, Dierck & Bonin, Tim & Lührs, Christian & Franke, Gesa & Hagen-Eggert, Martin & Koch, Peter & Hüttmann, Gereon. (2012). Common approach for compensation of axial motion artifacts in swept-source OCT and dispers… [cited by examiner]
Clara Pfäffle, Hendrik Spahr, Dierck Hillmann, Helge Sudkamp, Gesa Franke, Peter Koch, and Gereon Hüttmann, “Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction… [cited by examiner]
Kraus, M. F. et al., “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns.” Biomedical Optics Express. Jun. 2012. vol. 3, No. 6. p. 1182. Optical Society of Ame… [cited by applicant]
Danielson, B.L. et al., “Absolute optical ranging using low coherence interferometry,” Applied Optics, vol. 30. No. 21. p. 2975-2979, Jul. 1991. [cited by applicant]
Hariri, S. et al., “Limiting factors to the OCT axial resolution for in-vivo imaging of human and rodent retina in the 1060nm wavelength range,” Optical Express, vol. 17. No. 26, p. 24304-24316. Mar. 2009 Optical Societ… [cited by applicant]
Van Den Berg, T.J. et al., “Near infrared light absorption in the human eye media,” Vision Res. vol. 37 No. 2 , p. 249-253, 1997. Elsevier Science Ltd. [cited by applicant]
Coello, Y. et al., “Group-velocity dispersion measurements of water, seawater, and ocular components using multiphoton intrapulse interference phase scan,” Applied. Optics., vol. 46 No. 35. p. 8394-8401. 2007 Optical So… [cited by applicant]
Drexler, W. et al., “State-of-the-art retinal optical coherence tomography,” Science Direct. Progress in Retinal Eye Research vol. 27 p. 45-88. 2008 Elsevier Ltd. [cited by applicant]
Drexler, W. et al., “In vivo ultrahigh-resolution optical coherence tomography,” Optics Letter vol. No. 1724, p. 1221-1223, 1999 Optical Society of America. [cited by applicant]
Potsaid, B. et al., “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Optical Express vol. 16, No. 19. p. 5149-15169. 2008 Optical Society of America. [cited by applicant]
Povazay, B. et al., “Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050 nm,” Optical Express vol. 11, No. 17. p. 1980-1986. 2003 Optical Society of America. [cited by applicant]
Unterhuber, A. et al., “In vivo retinal optical coherence tomography at 1040 nm-enhanced penetration into the choroid,” Optical Express vol. 13 No. 9. p. 3252-3258. 2005 Optical Society of America. [cited by applicant]
Yasuno, Y. et al., “In vivo high-contrast imaging of deep posterior eye by 1-μm swept source optical coherence tomography and scattering optical coherence angiography,” Optical Express vol. 15, No. 10. p. 6121-6139. 200… [cited by applicant]
Hillman, T. et al., “The effect of water dispersion and absorption on axial resolution in ultrahigh resolution optical coherence tomography,” Optical Express, vol. 13 No. 6. p. 1860-1874, 2005 Optical Society of America. [cited by applicant]
Wolbarsht, M. L. et al., “Melanin, a unique biological absorber,” Applied Optics vol. 20, No. 13. p. 2184-2186, 1981 Optical Society of America. [cited by applicant]
Wang, Y., “Optimal wavelength for ultrahighresolution optical coherence tomography,” Optical Express vol. 11 , No. 12. p. 1411-1417, 2003 Optical Society of America. [cited by applicant]
Klein, T. et al., “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Optical Express vol. 19, No. 4. p. 3044-3062. 2011 Optical Society of America. [cited by applicant]
Huber, R. et al., “Fourier domain mode locking at 1050 nm for ultrahigh-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Optical Letter vol. 32, No. 14. p. 2049-2051. 2007 Optic… [cited by applicant]
Kuznetsov, M. et al., “Compact ultrafast reflective Fabry-Perot tunable lasers for oct imaging applications,” Proceedings of SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XI… [cited by applicant]
Marschall, S. et al., “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Optical Express vol. 18, No. 15. p. 15820-15831. 2010 Optical Society of America. [cited by applicant]
Marschall, S. et al., “Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm,” Proceedings of SPIE 8213, Proceedings vol. 8213, Optical Coherence Tomography and Coherence Domain Optical … [cited by applicant]
Hillmann, D. et al., “Holoscopy—holographic optical coherence tomography” Optics Letters vol. 36, No. 13. p. 2390. 2011 Optical Society of America. [cited by applicant]
Nakamura, Y. et al., “High-Speed three dimensional human retinal imaging by line field spectral domain optical coherence tomography” Optics Express vol. 15, No. 12 p. 7103. 2007 Optical Society of America. [cited by applicant]
Blazkiewicz et al., “Signal-to-noise ratio study of full-field Fourier-domain optical coherence tomography,” Applied Optics. vol. 44, No. 36. p. 7722. 2005 Optical Society of America. [cited by applicant]
Marschall, S., “Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range,” Biomed. Opical Express vol. 3, No. 7. p. 1620-1631, 2012 Optical Society of America. [cited by applicant]
Palmer, K. F. et al., “Optical properties of water in the near infrared,” Journal of Optical Society of America, vol. 64, No. 8. p. 1107-1110, 1974. [cited by applicant]
Lee, Song-Won, “Optimization for Axial Resolution, Depth Range, and Sensitivity of Spectral Domain Optical Coherence Tomography at 1.3 μm”, J Korean Phys Soc., vol. 55, No. 6. p. 2354-2360, 2009. doi:10.3938/ikps.55.235… [cited by applicant]
Godenschweger, F. et al., “Motion correction in MRI of the brain,” Phys Med Biol. Mar. 7, 2016. vol. 61, No. 5. p. R32-R56. doi:10.1088/0031-9155/61/5/R32. HHS Public Access. [cited by applicant]