IP Library › Granted Patent US 12,414,920
Granted Patent B2
US 12,414,920 · App. 17/566,226 · Granted Sep 16, 2025

Spray-dried blood products and methods of making same

Inventors: Thomas H. Fischer (Durham, NC); Joseph A DaCorta (Durham, NC); Michael Lawrence Galiger (Durham, NC)
Assignee: Velico Medical Inc.
A61K9/1688A61F13/00063A61K9/0026A61K35/16A61K35/19A61L15/40A61L26/0047A61L26/0057A61L26/0076A61F2013/00306A61F2013/00472A61F2013/00927
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Quick Facts
Patent No.
US 12,414,920
App. No.
17/566,226
Granted
Sep 16, 2025
Kind
B2
Abstract

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.

Claims (18)

1. A method of preparing dehydrated plasma, comprising the steps of:

a) providing hydrated plasma; and

b) spray drying said hydrated plasma at a temperature of at least about 110° C. to produce dehydrated plasma wherein one or more coagulation factors are retained after drying.

2. The method of claim 1 , wherein said hydrated plasma is physically or chemically modified.

3. The method of claim 2 , wherein said modification is chemical fixation.

4. The method of claim 2 , wherein said modification comprises additional diagnostic or therapeutic reagents.

5. The method of claim 4 , wherein said diagnostic or therapeutic reagents are selected from the group consisting of imaging agents, concentration factors, performance enhancement drugs, antimicrobial and antiviral reagents, universal donor solutions, and combinations thereof.

6. The method of claim 1 , wherein the one or more coagulation factor include FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII, protein S, protein C, von Willebrand factor, or a combination thereof.

7. The method of claim 1 , wherein the step b) includes spray drying said hydrated plasma at a temperature between about 110° C. and about 140° C.

8. A method of preparing spray dried plasma, comprising the steps of:

a) providing hydrated plasma; and

b) spray drying said hydrated plasma by a spray dryer at a temperature of at least about 110° C., wherein when rehydrated, the spray dried plasma has one or more coagulation factor levels of concentration and activity that are essentially the same as said hydrated plasma.

9. The method of claim 8 , wherein the one or more coagulation factor include FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII, proteinS, protein C, von Willebrand factor, or a combination thereof.

10. A method of preparing dehydrated plasma, comprising the steps of:

a) providing hydrated plasma; and

b) spray drying said hydrated plasma at a temperature of at least about 110° C. to produce dehydrated plasma; wherein, when rehydrated, the dehydrated plasma has one or more coagulation factor levels that induce clot formation.

11. The method of claim 10 , wherein the one or more coagulation factor levels that induce clot formation include FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII, protein S, protein C, von Willebrand factor, or a combination thereof.

12. The method of claim 10 , wherein the step b) includes spray drying said hydrated plasma at a temperature between about 110° C. and about 140° C.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2025
From: DACORTA, JOSEPH A; FISCHER, THOMAS H; GALIGER, MICHAEL L
To: ENTEGRION, INC.
Reel/Frame 072096/0124 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2025
From: ENTEGRION, INC
To: VELICO MEDICAL, INC
Reel/Frame 072096/0228 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2022
From: ENTEGRION, INC.
To: VELICO MEDICAL, INC.
Reel/Frame 061250/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2021
From: FISCHER, THOMAS H.; DACORTA, JOSEPH A.; GALIGER, MICHAEL L.
To: ENTEGRION, INC.
Reel/Frame 058510/0424 →
Continuity (4)
Division 15872727 · Jan 16, 2018
Continuation 13262931
Provisional Application 61212321 · Apr 9, 2009
Related Publication 20220117897A1 · Apr 21, 2022
References Cited (400)
US 2362025A · Price · 1943 [cited by applicant]
US 2411152A · Folsom · 1946 [cited by applicant]
US 2528476A · Roos et al. · 1950 [cited by applicant]
US 2575175A · Kronisch · 1951 [cited by applicant]
US 3228838A · Rinfret et al. · 1966 [cited by applicant]
US 3230689A · Hussmann · 1966 [cited by applicant]
US 3449124A · Lipner · 1969 [cited by applicant]
US 3507278A · Werding · 1970 [cited by applicant]
US 3644128A · Lipner · 1972 [cited by applicant]
US 3654705A · Smith et al. · 1972 [cited by applicant]
US 3693886A · Conrad · 1972 [cited by applicant]
US 3735792A · Asizawa et al. · 1973 [cited by applicant]
US 3945574A · Polnauer · 1976 [cited by applicant]
US 4187617A · Becker et al. · 1980 [cited by applicant]
US 4251510A · Tankersley · 1981 [cited by applicant]
US 4347259A · Suzuki et al. · 1982 [cited by applicant]
US 4358901A · Takabatake et al. · 1982 [cited by applicant]
US 4376010A · Gauvin · 1983 [cited by applicant]
US 4378346A · Tankersley · 1983 [cited by applicant]
US 4380491A · Joy · 1983 [cited by applicant]
US 4422900A · Bordelon · 1983 [cited by applicant]
US 4597868A · Watanabe · 1986 [cited by applicant]
US 4600613A · Yoshida · 1986 [cited by applicant]
US 4645482A · Yoshida · 1987 [cited by applicant]
US 4705612A · Shimomura et al. · 1987 [cited by applicant]
US 4725355A · Yamamoto et al. · 1988 [cited by applicant]
US 4735832A · Ichikawa et al. · 1988 [cited by applicant]
US 4743375A · Seita et al. · 1988 [cited by applicant]
US 4774019A · Watanabe et al. · 1988 [cited by applicant]
US 4787154A · Titus · 1988 [cited by applicant]
US 4845132A · Masuoka et al. · 1989 [cited by applicant]
US 4861632A · Caggiano · 1989 [cited by applicant]
US 4966699A · Sasaki et al. · 1990 [cited by applicant]
US 5096537A · Bergquist et al. · 1992 [cited by applicant]
US 5139529A · Seita et al. · 1992 [cited by applicant]
US 5145706A · Jagi et al. · 1992 [cited by applicant]
US 5167763A · Sakamoto · 1992 [cited by applicant]
US 5181415A · Esvan et al. · 1993 [cited by applicant]
US 5227017A · Tanaka · 1993 [cited by applicant]
US 5244578A · Ohnishi et al. · 1993 [cited by applicant]
US 5252221A · van Dommelen et al. · 1993 [cited by applicant]
US 5254248A · Nakamura · 1993 [cited by applicant]
US 5257983A · Garyantes et al. · 1993 [cited by applicant]
US 5267646A · Inoue et al. · 1993 [cited by applicant]
US 5279738A · Seita et al. · 1994 [cited by applicant]
US 5309649A · Bergmann et al. · 1994 [cited by applicant]
US 5372811A · Yoder · 1994 [cited by applicant]
US 5447077A · Lautenschlager · 1995 [cited by applicant]
US 5499768A · Tanaka · 1996 [cited by applicant]
US 5522156A · Ware · 1996 [cited by applicant]
US 5523004A · Tanokura et al. · 1996 [cited by applicant]
US 5529821A · Ishikawa et al. · 1996 [cited by applicant]
US 5547576A · Onishi et al. · 1996 [cited by applicant]
US 5562919A · Doty et al. · 1996 [cited by applicant]
US 5567238A · Long, Jr. · 1996 [cited by applicant]
US 5575999A · Yoder · 1996 [cited by applicant]
US 5581903A · Botich · 1996 [cited by applicant]
US 5582794A · Hagiwara et al. · 1996 [cited by applicant]
US 5624530A · Sadykhov · 1997 [cited by applicant]
US 5647142A · Andersen et al. · 1997 [cited by applicant]
US 5657555A · Milojevic · 1997 [cited by applicant]
US 5680712A · Kiyokawa · 1997 [cited by applicant]
US 5610170A · Inoue et al. · 1997 [cited by applicant]
US 5727333A · Folan · 1998 [cited by applicant]
US 5838515A · Mortazavi et al. · 1998 [cited by applicant]
US 5924216A · Takahashi · 1999 [cited by applicant]
US 5993804A · Read et al. · 1999 [cited by applicant]
US 6004576A · Weaver et al. · 1999 [cited by applicant]
US 6005857A · Honkasalo et al. · 1999 [cited by applicant]
US 6060323A · Jina · 2000 [cited by applicant]
US D430939S · Zukor et al. · 2000 [cited by applicant]
US 6148536A · Lijima · 2000 [cited by applicant]
US 6197289B1 · Wirt et al. · 2001 [cited by applicant]
US 6223455B1 · Chickering, III · 2001 [cited by applicant]
US 6284282B1 · Maa et al. · 2001 [cited by applicant]
US 6299906B1 · Bausch et al. · 2001 [cited by applicant]
US 6308434B1 · Chickering et al. · 2001 [cited by applicant]
US 6308826B1 · Merrell · 2001 [cited by applicant]
US 6345452B1 · Feuilloley et al. · 2002 [cited by applicant]
US 6463675B1 · Hansen et al. · 2002 [cited by applicant]
US 6523276B1 · Meldrum · 2003 [cited by applicant]
US 6582654B1 · Kral et al. · 2003 [cited by applicant]
US 6526774B1 · Lu et al. · 2003 [cited by applicant]
US 6560897B2 · Chickering et al. · 2003 [cited by applicant]
US 6569447B2 · Kisic et al. · 2003 [cited by applicant]
US 6723497B2 · Wolkers et al. · 2004 [cited by applicant]
US 6762336B1 · MacPhee · 2004 [cited by examiner]
US 6893412B2 · Saito et al. · 2005 [cited by applicant]
US 7005857B2 · Stiene et al. · 2006 [cited by applicant]
US 7007405B2 · Hajek et al. · 2006 [cited by applicant]
US 7007406B2 · Wang et al. · 2006 [cited by applicant]
US 7074582B2 · Fischer et al. · 2006 [cited by applicant]
US 7089681B2 · Herbert et al. · 2006 [cited by applicant]
US 7094378B1 · Goodrich, Jr. et al. · 2006 [cited by applicant]
US 7297716B2 · Shanbrom · 2007 [cited by applicant]
US 7361306B2 · Bole · 2008 [cited by applicant]
US 7399637B2 · Wright et al. · 2008 [cited by applicant]
US 7419682B2 · Campbell et al. · 2008 [cited by applicant]
US 7527805B2 · Crenshaw et al. · 2009 [cited by applicant]
US 7648699B2 · Goodrich et al. · 2010 [cited by applicant]
US 7931919B2 · Bakaltcheva et al. · 2011 [cited by applicant]
US 7993310B2 · Rosiello · 2011 [cited by applicant]
US 8322046B2 · Wang et al. · 2012 [cited by applicant]
US 8398732B2 · Turok et al. · 2013 [cited by applicant]
US 8407912B2 · Hubbard et al. · 2013 [cited by applicant]
US 8434242B2 · Hubbard et al. · 2013 [cited by applicant]
US 8449520B2 · Pepper et al. · 2013 [cited by applicant]
US 8469202B2 · Rosiello · 2013 [cited by applicant]
US 8518452B2 · Bjornstrup et al. · 2013 [cited by applicant]
US 8533971B2 · Hubbard et al. · 2013 [cited by applicant]
US 8533972B2 · Hubbard et al. · 2013 [cited by applicant]
US 8595950B2 · Hubbard et al. · 2013 [cited by applicant]
US 8601712B2 · Hubbard et al. · 2013 [cited by applicant]
US 8968879B2 · Inaba et al. · 2015 [cited by applicant]
US 9440011B2 · Van Waeg et al. · 2016 [cited by applicant]
US 9453676B2 · Robinson · 2016 [cited by applicant]
US 9545379B2 · Liu et al. · 2017 [cited by applicant]
US 9551527B2 · Beetz · 2017 [cited by applicant]
US 9561184B2 · Khan et al. · 2017 [cited by applicant]
US 9561893B2 · Root et al. · 2017 [cited by applicant]
US 9863699B2 · Corbin, III et al. · 2018 [cited by applicant]
US 9867782B2 · Fischer et al. · 2018 [cited by applicant]
US 9915473B2 · Ilan · 2018 [cited by applicant]
US 10022478B2 · Anzai et al. · 2018 [cited by applicant]
US 10251911B2 · DaCorta et al. · 2019 [cited by applicant]
US 10279359B2 · Ackerman · 2019 [cited by applicant]
US 10376614B2 · Kohama et al. · 2019 [cited by applicant]
US 10376809B2 · Nielsen · 2019 [cited by applicant]
US 10377520B2 · Root et al. · 2019 [cited by applicant]
US 10539367B2 · Corbin, III et al. · 2020 [cited by applicant]
US 10793327B2 · Weimer et al. · 2020 [cited by applicant]
US 10806665B2 · Murto · 2020 [cited by applicant]
US 10843100B2 · Khan et al. · 2020 [cited by applicant]
US 10960023B2 · DaCorta et al. · 2021 [cited by applicant]
US 10969171B2 · Corbin, III et al. · 2021 [cited by applicant]
US 11052045B2 · Liu et al. · 2021 [cited by applicant]
US 11213488B2 · Fischer et al. · 2022 [cited by applicant]
US 11841189B1 · Andrews · 2023 [cited by applicant]
US 11913722B1 · Andrews · 2024 [cited by applicant]
US 11913723B1 · Andrews · 2024 [cited by applicant]
US 11975274B2 · Liu · 2024 [cited by applicant]
US 11998861B2 · Andrews · 2024 [cited by applicant]
US 20020056206A1 · Pace · 2002 [cited by applicant]
US 20020122803A1 · Kisic et al. · 2002 [cited by applicant]
US 20020182195A1 · Marguerre et al. · 2002 [cited by applicant]
US 20030037459A1 · Checkering, III et al. · 2003 [cited by applicant]
US 20030099633A1 · Campbell et al. · 2003 [cited by applicant]
US 20030103962A1 · Campbell et al. · 2003 [cited by applicant]
US 20030143518A1 · Luck et al. · 2003 [cited by applicant]
US 20030163931A1 · Beyerinck · 2003 [cited by applicant]
US 20030180283A1 · Batycky et al. · 2003 [cited by applicant]
US 20030186004A1 · Koslow · 2003 [cited by applicant]
US 20030190314A1 · Campbell et al. · 2003 [cited by applicant]
US 20030209245A1 · Poole et al. · 2003 [cited by applicant]
US 20040058309A1 · Washizu · 2004 [cited by applicant]
US 20040086420A1 · MacPhee · 2004 [cited by applicant]
US 20040110871A1 · Perrut et al. · 2004 [cited by applicant]
US 20040146565A1 · Stronbehn et al. · 2004 [cited by applicant]
US 20040175296A1 · Opalsky et al. · 2004 [cited by applicant]
US 20040202660A1 · Campbell et al. · 2004 [cited by applicant]
US 20040247628A1 · Lintz et al. · 2004 [cited by applicant]
US 20050142208A1 · Yoo · 2005 [cited by applicant]
US 20050170068A1 · Roodink et al. · 2005 [cited by applicant]
US 20050186183A1 · DeAngelo et al. · 2005 [cited by applicant]
US 20050271674A1 · Campbell et al. · 2005 [cited by applicant]
US 20060045907A1 · Campbell et al. · 2006 [cited by applicant]
US 20060088642A1 · Boersen et al. · 2006 [cited by applicant]
US 20060130768A1 · Crenshaw et al. · 2006 [cited by applicant]
US 20060216687A1 · Alves-Filho et al. · 2006 [cited by applicant]
US 20060222980A1 · Makino et al. · 2006 [cited by applicant]
US 20070014806A1 · Marguerre et al. · 2007 [cited by applicant]
US 20070084244A1 · Rosenflanz et al. · 2007 [cited by applicant]
US 20070166389A1 · Bakaltcheva · 2007 [cited by applicant]
US 20080058469A1 · Abe et al. · 2008 [cited by applicant]
US 20080060213A1 · Gehrmann et al. · 2008 [cited by applicant]
US 20080119818A1 · Bakaltcheva et al. · 2008 [cited by applicant]
US 20080138340A1 · Campbell et al. · 2008 [cited by applicant]
US 20080145444A1 · Merchant et al. · 2008 [cited by applicant]
US 20080145834A1 · Ho · 2008 [cited by applicant]
US 20080213263A1 · Campbell et al. · 2008 [cited by applicant]
US 20080234653A1 · McCarthy et al. · 2008 [cited by applicant]
US 20080317640A1 · Mayer · 2008 [cited by applicant]
US 20090092678A1 · Marguerre et al. · 2009 [cited by applicant]
US 20090155410A1 · Crenshaw et al. · 2009 [cited by applicant]
US 20090113753A1 · Pepper et al. · 2009 [cited by applicant]
US 20090145783A1 · Forker · 2009 [cited by applicant]
US 20090223080A1 · McCarthy · 2009 [cited by applicant]
US 20100011610A1 · Bittorf · 2010 [cited by applicant]
US 20100108183A1 · Rosiello · 2010 [cited by applicant]
US 20100215667A1 · Campbell et al. · 2010 [cited by applicant]
US 20100233671A1 · Bakaltcheva · 2010 [cited by applicant]
US 20100273141A1 · Bakaltcheva · 2010 [cited by applicant]
US 20110142885A1 · Haley et al. · 2011 [cited by applicant]
US 20110282325A1 · Gregory · 2011 [cited by applicant]
US 20120027867A1 · Fischer et al. · 2012 [cited by applicant]
US 20120103536A1 · Hubbard et al. · 2012 [cited by applicant]
US 20120167405A1 · Hubbard et al. · 2012 [cited by applicant]
US 20120222326A1 · Hubbard et al. · 2012 [cited by applicant]
US 20130000774A1 · Rosiello · 2013 [cited by applicant]
US 20130048225A1 · Hubbard et al. · 2013 [cited by applicant]
US 20130056158A1 · Hubbard et al. · 2013 [cited by applicant]
US 20130126101A1 · Hubbard, Jr. et al. · 2013 [cited by applicant]
US 20130129817A1 · Consigny · 2013 [cited by applicant]
US 20130209985A1 · Hoke · 2013 [cited by applicant]
US 20130243877A1 · Haley · 2013 [cited by applicant]
US 20130264288A1 · Hlavinka et al. · 2013 [cited by applicant]
US 20140083627A1 · Khan et al. · 2014 [cited by applicant]
US 20140083628A1 · Khan et al. · 2014 [cited by applicant]
US 20140088768A1 · Haley et al. · 2014 [cited by applicant]
US 20140221873A1 · Hayakawa et al. · 2014 [cited by applicant]
US 20140230266A1 · Luy et al. · 2014 [cited by applicant]
US 20150099866A1 · Kelleher · 2015 [cited by applicant]
US 20150158652A1 · Root et al. · 2015 [cited by applicant]
US 20150354894A1 · Corbin, III et al. · 2015 [cited by applicant]
US 20160015863A1 · Gupta et al. · 2016 [cited by applicant]
US 20160082043A1 · Khan et al. · 2016 [cited by applicant]
US 20160082044A1 · Liu · 2016 [cited by applicant]
US 20160084572A1 · Khan et al. · 2016 [cited by applicant]
US 20160113965A1 · DaCorta et al. · 2016 [cited by applicant]
US 20160223255A1 · Beetz · 2016 [cited by applicant]
US 20160362307A1 · Shiner · 2016 [cited by applicant]
US 20170100339A1 · Liu et al. · 2017 [cited by applicant]
US 20170113824A1 · Root et al. · 2017 [cited by applicant]
US 20170203871A1 · Murto et al. · 2017 [cited by applicant]
US 20170259186A1 · Khan et al. · 2017 [cited by applicant]
US 20170367322A1 · Liu et al. · 2017 [cited by applicant]
US 20180128544A1 · Corbin et al. · 2018 [cited by applicant]
US 20180153811A1 · Fischer et al. · 2018 [cited by applicant]
US 20180207654A1 · Phua · 2018 [cited by applicant]
US 20180229150A1 · Sorensen · 2018 [cited by applicant]
US 20190106254A1 · Weimer et al. · 2019 [cited by applicant]
US 20190223671A1 · Tomasiak · 2019 [cited by applicant]
US 20190241300A1 · Root et al. · 2019 [cited by applicant]
US 20190255455A9 · Sorensen · 2019 [cited by applicant]
US 20190298765A1 · DaCorta et al. · 2019 [cited by applicant]
US 20200022691A1 · Pollack · 2020 [cited by applicant]
US 20200298137A9 · Khan · 2020 [cited by applicant]
US 20210069607A1 · Khan et al. · 2021 [cited by applicant]
US 20210213057A1 · DaCorta et al. · 2021 [cited by applicant]
US 20210290545A1 · Lie et al. · 2021 [cited by applicant]
US 20220040110A1 · Lie et al. · 2022 [cited by applicant]
US 20220106357A1 · Patatanyan · 2022 [cited by applicant]
US 20230172849A1 · Zeki · 2023 [cited by applicant]
US 20240109000A1 · Liu · 2024 [cited by applicant]
US 20240131062A1 · Popovsky · 2024 [cited by applicant]
US 20240131236A1 · LaRocque · 2024 [cited by applicant]
US 20240131446A1 · Andrews · 2024 [cited by applicant]
US 20240159462A1 · Andrews · 2024 [cited by applicant]
US 20240191943A1 · Andrews · 2024 [cited by applicant]
AU 2010234607 · 2010 [cited by applicant]
CA 1182411 · 1985 [cited by applicant]
CA 1182411A · 1985 [cited by applicant]
CA 2065582 · 1992 [cited by applicant]
CA 2065582A1 · 1992 [cited by applicant]
CA 2472028 · 2003 [cited by applicant]
CA 2757961 · 2010 [cited by applicant]
CA 2816090A1 · 2012 [cited by applicant]
CH 622683 · 1981 [cited by applicant]
CH 622683A5 · 1981 [cited by applicant]
CN 1315139 · 2001 [cited by applicant]
CN 1315139A · 2001 [cited by applicant]
CN 102206273A · 2011 [cited by applicant]
CN 108005711A · 2018 [cited by applicant]
CN 111789867B · 2022 [cited by applicant]
DE 3507278 · 1986 [cited by applicant]
EP 0058903 · 1982 [cited by applicant]
EP 0058903A1 · 1982 [cited by applicant]
EP 0408801A1 · 1991 [cited by applicant]
EP 1050220A1 · 2000 [cited by applicant]
EP 1050220 · 2000 [cited by applicant]
EP 2745922A2 · 2014 [cited by applicant]
EP 2745923A2 · 2014 [cited by applicant]
EP 2416790 · 2018 [cited by applicant]
EP 3151662B1 · 2020 [cited by applicant]
GB 573500 · 1945 [cited by applicant]
GB 886533 · 1962 [cited by applicant]
GB 964367 · 1964 [cited by applicant]
GB 975786 · 1964 [cited by applicant]
GB 1188168 · 1970 [cited by applicant]
GB 2003042 · 1979 [cited by applicant]
GB 2003042A · 1979 [cited by applicant]
HK 1167098 · 2012 [cited by applicant]
JP 6011903 · 1981 [cited by applicant]
JP 56011903 · 1981 [cited by applicant]
JP 3218201 · 1988 [cited by applicant]
JP 63218201 · 1988 [cited by applicant]
JP 1011618 · 1989 [cited by applicant]
JP 3131302 · 1991 [cited by applicant]
JP 3181301 · 1991 [cited by applicant]
JP 525910 · 1993 [cited by applicant]
JP 5245301 · 1993 [cited by applicant]
JP 5252910 · 1993 [cited by applicant]
JP 10182124 · 1998 [cited by applicant]
JP H10182124A · 1998 [cited by applicant]
JP 3219828B2 · 2001 [cited by applicant]
JP 2002009037 · 2002 [cited by applicant]
JP 2005191275 · 2005 [cited by applicant]
JP 2005191275A · 2005 [cited by applicant]
JP 2007216158 · 2007 [cited by applicant]
JP 2007216158A · 2007 [cited by applicant]
JP 6336419 · 2018 [cited by applicant]
KR 911657B1 · 2009 [cited by applicant]
KR 2022079809A · 2022 [cited by applicant]
MX 2011010633 · 2012 [cited by applicant]
WO 1996015849 · 1996 [cited by applicant]
WO WO1996015849A1 · 1996 [cited by applicant]
WO 1996018312 · 1996 [cited by applicant]
WO WO1996018312A1 · 1996 [cited by applicant]
WO 1997038578 · 1997 [cited by applicant]
WO WO1997038578A1 · 1997 [cited by applicant]
WO 1999007236 · 1999 [cited by applicant]
WO 1999007390 · 1999 [cited by applicant]
WO WO1999007236A1 · 1999 [cited by applicant]
WO WO1999007390A1 · 1999 [cited by applicant]
WO 2000056166 · 2000 [cited by applicant]
WO WO2000056166A1 · 2000 [cited by applicant]
WO 2001072141 · 2001 [cited by applicant]
WO WO2001072141A2 · 2001 [cited by applicant]
WO 2002078741 · 2002 [cited by applicant]
WO 2002078742 · 2002 [cited by applicant]
WO WO2002078741A2 · 2002 [cited by applicant]
WO WO2002078742A2 · 2002 [cited by applicant]
WO WO2002083157A1 · 2002 [cited by applicant]
WO 2002092213 · 2002 [cited by applicant]
WO WO2002092213A1 · 2002 [cited by applicant]
WO 2003030654 · 2003 [cited by applicant]
WO 2003030918 · 2003 [cited by applicant]
WO WO2003030654A1 · 2003 [cited by applicant]
WO WO2003030918A1 · 2003 [cited by applicant]
WO WO03037303A · 2003 [cited by applicant]
WO 2003063607 · 2003 [cited by applicant]
WO WO2003063607A1 · 2003 [cited by applicant]
WO 2004057962 · 2004 [cited by applicant]
WO 2004075988 · 2004 [cited by applicant]
WO WO2004075988A2 · 2004 [cited by applicant]
WO WO2004078187A1 · 2004 [cited by applicant]
WO WO2005079755A2 · 2005 [cited by applicant]
WO 2007036227 · 2007 [cited by applicant]
WO WO2007036227A1 · 2007 [cited by applicant]
WO WO2008080167A2 · 2008 [cited by applicant]
WO 2008122288 · 2008 [cited by applicant]
WO WO2008122288A1 · 2008 [cited by applicant]
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WO 2010117976 · 2010 [cited by applicant]
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WO WO2024059764A1 · 2024 [cited by applicant]
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WO WO2024059768A1 · 2024 [cited by applicant]
WO WO2024059769A1 · 2024 [cited by applicant]
WO WO2024059770 · 2024 [cited by applicant]
WO WO2024059771A1 · 2024 [cited by applicant]
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WO WO2024059774A1 · 2024 [cited by applicant]
Polo, J. et al., Efficacy of spray-drying to reduce infectivity of pseudorabie and porcine reproductive and respiratory syndrome (PRRS) viruses and seroconversion in p. fed diets containing spray-dried animal plasma, Jo… [cited by applicant]
Hawksworth, J.S. et al., Evaluation of lyophilized platelets as an infusible hemostatic agent in experimental non-compressible hemorrhage in swine, Journal of Thrombosis and Haemostasis, Oct. 2009, vol. 7, No. 10, pp. 1… [cited by applicant]
Shuja, Fahad et al., Development and Testing of Low-Volume Hyperoncotic, Hyperosmotic Spray-Dried Plasma for the Treatment of Trauma-Associated Coagulopathy, Journal of Trauma Injury Infection and Critical Care, Mar. 20… [cited by applicant]
Shuja et al., Development and Testing of Freeze-Dried Plasma for the Treatment of Trauma-Associated Coagulopathy, The Journal of Trauma Injury, Infection and Critical Care, Presented at the 38th Annual Meeting of the We… [cited by applicant]
Solheim B G et al., Improved Preservation of Coagulation Factors After Pre-Storage Leukocyte Depletion of Whole Blood; Transfus Apher Sci., Oct. 29, 2003.(2): pp. 133-139. [cited by applicant]
Goto et al., Characterization of the Unique Mechanism Mediating the Shear-dependent Binding of Soluble von Willebrand Factor to Platelets, The Journal of Biological Chemistry, vol. 270, No. 40, Oct. 6, 1995, pp. 23352-2… [cited by applicant]
Horn, R.G., Addition of a polarizing microscope to the Weissenberg Rheogoniometer, 1979 American Institute of Physics, Rev. Sci. Instrum. 50(50, May 1979, pp. 659-661. [cited by applicant]
Moake, et al., Involvement of Large Plasma von Willebrand Factor (VWF) Multimers and Unusually Large vWF Forms Derived from Endothelial Cells in Shear Stress-induced Platelet Aggregation, The American Society for Clinic… [cited by applicant]
Mini Spray Dryer B-290; Application Note; www.buchi.com; Mar. 30, 2008. [cited by applicant]
Nano Spray Dryer B-90; www.buchi.com; Jul. 18, 2011. [cited by applicant]
Lea, et al. “The Reaction between Proteins and Reducing Sugars in the “Dry” State” Department of Pathology, University of Cambridge; Jun. 5, 1950; pp. 626-629. [cited by applicant]
Carpenter, et al. “Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice” Kluwer Academic/Plenum Publishers; 2002; pp. 109-133. [cited by applicant]
Schmid “Spray drying of protein precipitates and Evaluation of the Nano Spray Dryer B-90” PhD Thesis; 2011; 125 pages. [cited by applicant]
Shuja, et al. “Development and Testing of Low-Volume Hyperoncotic, Hyperosmotic Spray-Dried Plasma for the treatment of Trauma-Associated Coagulopathy” The Journal of Trauma; Mar. 2011; vol. 70; No. 3; pp. 664-671. [cited by applicant]
Bakaltcheva; et al. “Freeze-dried whole plasma: Evaluating sucrose, trehalose, sorbitol, mannitol and glycine as stabilizers” Thrombosis Research; 2007; vol. 120; pp. 105-116. [cited by applicant]
European Search Report, EP Application No. 14154366, mailed Aug. 29, 2014, pp. 1-3. [cited by applicant]
European Search Opinion, EP Application No. 14154366, mailed Aug. 29, 2014, pp. 1-3. [cited by applicant]
International Search Report and Written Opinion, PCT/US2010/049176, mailed Nov. 4, 2010, pp. 1-10. [cited by applicant]
International Search Report and Written Opinion, PCT/US2011/058358, mailed Jul. 4, 2012, pp. 1-9. [cited by applicant]
Answer, Affirmative Defenses, Counterclaims, Cross-Claims and Jury Demand, [cited by applicant]
Civil Action Cover Sheet; [cited by applicant]
Complaint including Exhibit A, B, and C; [cited by applicant]
Mini Spray Dryer B-290—Application Note; www.buchi.com; Mar. 30, 2008, entire document; 1 page. [cited by applicant]
Nano Spray Dryer B-90; www.buchi.com; Jul. 18, 2011, entire document, 12 pages. [cited by applicant]
Mini Spray Dryer System Configuration; www.buchi.com; Jan. 8, 2007, entire document, 1 page. [cited by applicant]
Quick Operation Guide; Mini Spray Dryer B-290; www.buchi.com; Sep. 16, 2004, pp. 15-53. [cited by applicant]
Process Parameters; www.buchi.com; Nov. 21, 2008, pp. 1-2. [cited by applicant]
Training Papers Spray Drying; Version B; www.buchi.com; 19 pages; Oct. 29, 2002. [cited by applicant]
Mini Spray Dryer B-290; www.buchi.com; May 10, 2007, pp. 1-8. [cited by applicant]
Fischer M., et al., “Stability of African swine fever virus on spiked spray-dried porcine plasma,” [cited by applicant]
International Preliminary Report on Patentability, PCT/US2011/058358, mailed Apr. 30, 2013, pp. 1-7. [cited by applicant]
Edwards et al., The Preparation and Use of Dried Plasma for Transfusion; British Medical journal; vol. 1, No. 4131;Mar. 9, 1940; pp. 377-381. [cited by applicant]