IP Library Granted Patent US 12,415,021
Granted Patent B2
US 12,415,021 · App. 18/298,860 · Granted Sep 16, 2025

Extracorporeal blood filtering machine and methods

Inventors: Vitaliy Gennad'yevich Epshteyn (Maple Grove, MN); Steven Daniel Sandoval (Eden Prairie, MN); Kalley Francis Berg (Lino Lakes, MN); Franz Willems Ulrich (Minneapolis, MN)
Assignee: NUWELLIS, INC.
A61M1/154A61M1/1601A61M1/36224A61M1/10A61M1/14A61M1/155A61M1/1562A61M1/15632A61M1/1566A61M1/16A61M1/1643A61M1/1694A61M1/34A61M1/3403A61M1/341A61M1/3413A61M1/342A61M1/3424A61M1/3427A61M1/3431A61M1/3434A61M1/3437A61M1/3441A61M1/3444A61M1/3451A61M1/3607A61M1/361A61M1/36225A61M1/362262A61M1/362264A61M1/362266A61M1/3624A61M1/3626A61M1/3627A61M1/3639A61M1/3644A61M1/3663A61M1/3672A61M5/1415A61M5/165A61M5/172A61M60/109A61M60/268A61M2202/0042A61M2205/3331A61M2205/3368A61M2205/3379A61M2205/3393A61M2205/50A61M2205/502A61M2205/505A61M2205/82A61M2205/8206A61M2205/8262A61M2230/005
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Quick Facts
Patent No.
US 12,415,021
App. No.
18/298,860
Granted
Sep 16, 2025
Kind
B2
Abstract

An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale.

Claims (57)

1. An extracorporeal blood filtering machine comprising:

a blood circuit that includes:

a blood line comprising a blood inlet configured to receive blood from a patient and a blood outlet configured to return the blood to the patient,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump configured to pump the blood from the blood inlet to the blood outlet through the filter, the filter configured to remove waste from the blood;

an effluent circuit that includes:

an effluent line fluidly connected to the filter, the effluent line configured to receive the waste from the filter in the form of effluent, and

an effluent pump configured to pump the effluent from the filter through the effluent line into an effluent receptacle;

a hemolysis sensor configured to sample the effluent in the effluent line and/or the blood in the blood line and output a hemolysis signal indicative of a detected degree of hemolysis; and

a controller in communication with the blood pump, the effluent pump, and the hemolysis sensor, the controller configured to receive the hemolysis signal and to output a hemolysis alert signal if the detected degree of hemolysis exceeds a hemolysis threshold.

2. The extracorporeal blood filtering machine of claim 1 , wherein the hemolysis sensor is in optical communication with the effluent line and is configured to sample the effluent in the effluent line.

3. The extracorporeal blood filtering machine of claim 1 , wherein the hemolysis sensor is fluidly connected to the blood line and configured to sample the blood in the blood line.

4. The extracorporeal blood filtering machine of claim 1 , further comprising a display in communication with the controller, wherein the display is configured to receive the hemolysis alert signal from the controller and display a hemolysis alert.

5. The extracorporeal blood filtering machine of claim 1 , further comprising a blood leak detector configured to detect a presence of blood within the effluent line, wherein the controller is in communication with the blood leak detector and is configured to output a blood leak alarm signal if the blood leak detector detects the presence of blood within the effluent line.

6. The extracorporeal blood filtering machine of claim 5 , wherein the controller is further configured to stop the effluent pump if the blood leak detector detects the presence of blood within the effluent line.

7. The extracorporeal blood filtering machine of claim 1 , wherein the hemolysis sensor is configured to sample the effluent in the effluent line and/or the blood in the blood line between the blood pump and the blood outlet.

8. The extracorporeal blood filtering machine of claim 7 , further comprising a reference hemolysis sensor in communication with the controller and configured to sample the blood in the blood line between the blood inlet and the blood pump and to output a reference hemolysis signal indicative of a reference degree of hemolysis.

9. The extracorporeal blood filtering machine of claim 8 , wherein the controller is configured to:

receive the reference hemolysis signal,

compare the reference hemolysis signal to the hemolysis signal, and

output a hemolysis mismatch alert signal if the hemolysis signal differs from the reference hemolysis signal by more than a threshold amount.

10. The extracorporeal blood filtering machine of claim 9 , further comprising a display in communication with the controller, wherein the display is configured to receive the hemolysis mismatch alert signal from the controller and display a blood pump hemolysis alert.

11. A method comprising:

providing an extracorporeal blood filtering machine that includes:

a blood circuit that includes:

a blood line comprising a blood inlet and a blood outlet,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump;

an effluent circuit that includes:

an effluent line fluidly connected to the filter, and

an effluent pump;

a hemolysis sensor; and

a controller in communication with the blood pump, the effluent pump, and the hemolysis sensor;

operating the extracorporeal blood filtering machine by the controller to:

pump blood with the blood pump from a patient into the blood inlet through the blood line to the filter and back to the patient through the blood line out of the blood outlet, the filter removing waste from the blood and providing the waste to the effluent line in the form of effluent, and

pump the effluent with the effluent pump through the effluent line into an effluent receptacle;

sampling the effluent in the effluent line and/or the blood in the blood line with the hemolysis sensor;

providing a hemolysis signal indicative of a detected degree of hemolysis from the hemolysis sensor to the controller; and

outputting a hemolysis alert signal with the controller if the detected degree of hemolysis exceeds a hemolysis threshold.

12. The method of claim 11 , wherein sampling the effluent in the effluent line and/or the blood in the blood line with the hemolysis sensor comprises sampling the effluent in the effluent line with the hemolysis sensor.

13. The method of claim 11 , wherein sampling the effluent in the effluent line and/or the blood in the blood line with the hemolysis sensor comprises sampling the blood in the blood line with the hemolysis sensor.

14. The method of claim 11 , wherein:

the extracorporeal blood filtering machine further includes a display in communication with the controller, and

the method further comprises the display receiving the hemolysis alert signal from the controller and displaying a hemolysis alert.

15. The method of claim 11 , wherein sampling the effluent in the effluent line and/or the blood in the blood line with the hemolysis sensor comprises sampling the effluent in the effluent line and/or the blood in the blood line between the blood pump and the blood outlet.

16. The method of claim 15 , wherein:

the extracorporeal blood filtering machine further includes a reference hemolysis sensor in communication with the controller,

the method further comprises:

sampling the blood in the blood line between the blood inlet and the blood pump with the reference hemolysis sensor,

providing a reference hemolysis signal indicative of a reference degree of hemolysis from the reference hemolysis sensor to the controller,

comparing the reference hemolysis signal to the hemolysis signal with the controller, and

outputting a hemolysis mismatch alert signal with the controller if the hemolysis signal differs from the reference hemolysis signal by more than a threshold amount.

17. The method of claim 16 , wherein:

the extracorporeal blood filtering machine further includes a display in communication with the controller,

the method further comprises:

providing the hemolysis mismatch alert signal from the controller to the display, and

displaying a blood pump hemolysis alert on the display.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2023
From: EPSHTEYN, VITALIY GENNAD'YEVICH; SANDOVAL, STEVEN DANIEL; BERG, KALLEY FRANCIS; ULRICH, FRANZ WILLEMS
To: NUWELLIS, INC.
Reel/Frame 063863/0857 →
Continuity (2)
Continuation 18171612 · Feb 20, 2023
Related Publication 20240277931A1 · Aug 22, 2024
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