IP Library › Granted Patent US 12,419,633
Granted Patent B2
US 12,419,633 · App. 18/468,724 · Granted Sep 23, 2025

Devices and methods for percutaneous tricuspid valve repair

Inventors: Adam Groothuis (Swampscott, MA); Steven D. Cahalane (Pelham, NH); Richard J. Morrill (North Billerica, MA); John Alexander (Pinehurst, NC)
Assignee: EDWARDS LIFESCIENCES CORPORATION
A61B17/0401A61B2017/00783A61B2017/0406A61B2017/0409A61B2017/0419A61B2017/0464
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Quick Facts
Patent No.
US 12,419,633
App. No.
18/468,724
Granted
Sep 23, 2025
Kind
B2
Abstract

A first end of a wire is transluminally penetrated through tissue at a first cardiovascular site of a subject. A capture device is transluminally advanced into the subject, and is used to capture the first end of the wire and pull the first end of the wire away from the first cardiovascular site. From the first end of the wire, a first anchor is tracked along the wire, and is then anchored to the tissue at the first cardiovascular site. A second anchor is anchored to tissue at a second cardiovascular site. Subsequently, the first and second cardiovascular sites are drawn together by applying tension between the first and second anchors. Other embodiments are also described.

Claims (37)

1. A method, comprising:

transluminally advancing a first end of a wire toward a first cardiovascular site via a vena cava of a subject;

transluminally penetrating the first end of the wire through tissue at the first cardiovascular site;

transluminally advancing a capture device into the subject;

using the capture device, capturing the first end of the wire and pulling the first end of the wire away from the first cardiovascular site;

from the first end of the wire, tracking a first anchor along the wire, and subsequently anchoring the first anchor to the tissue at the first cardiovascular site;

anchoring a second anchor to tissue at a second cardiovascular site of the subject; and

subsequently, drawing together the first cardiovascular site and the second cardiovascular site by applying tension between the first anchor and the second anchor.

2. The method according to claim 1 , further comprising tracking the second anchor along the wire prior to anchoring the second anchor.

3. The method according to claim 1 , further comprising transluminally advancing a locker, and using the locker to maintain the tension between the first anchor and the second anchor.

4. The method according to claim 1 , wherein penetrating the first end of the wire through the tissue at the first cardiovascular site comprises piercing the tissue at the first cardiovascular site with the first end of the wire.

5. The method according to claim 1 , wherein penetrating the first end of the wire through the tissue at the first cardiovascular site comprises making a hole in the tissue at the first cardiovascular site using radio frequency energy.

6. The method according to claim 1 , wherein:

the method further includes transluminally advancing the first end of the wire to the first cardiovascular site while the first end of the wire is disposed within a catheter, and

penetrating the first end of the wire through the tissue at the first cardiovascular site comprises piercing a hole in the tissue at the first cardiovascular site with an extendable needle of the catheter, and advancing the first end of the wire out of the catheter and through the hole.

7. The method according to claim 1 , wherein transluminally penetrating the first end of the wire through the tissue at the first cardiovascular site comprises transluminally penetrating the first end of the wire through the tissue at the first cardiovascular site while a second end of the wire remains disposed outside of the subject.

8. The method according to claim 7 , wherein pulling the first end of the wire away from the first cardiovascular site comprises pulling the first end of the wire away from the first cardiovascular site while the second end of the wire remains disposed outside of the subject.

9. The method according to claim 1 , wherein the tissue is tissue of a heart of the subject, and penetrating the first end of the wire through the tissue at the first cardiovascular site comprises penetrating the first end of the wire through the tissue of the heart.

10. The method according to claim 9 , wherein the tissue is tissue of a valve of the heart, and penetrating the first end of the wire through the tissue of the heart comprises penetrating the first end of the wire through the tissue of the valve.

11. The method according to claim 10 , wherein the valve is a tricuspid valve of the heart, and penetrating the first end of the wire through the tissue of the valve comprises penetrating the first end of the wire through tissue of the tricuspid valve.

12. The method according to claim 11 , wherein drawing together the first cardiovascular site and the second cardiovascular site comprises drawing together the first cardiovascular site and the second cardiovascular site in a manner that reshapes the tricuspid valve.

13. The method according to claim 12 , wherein the first cardiovascular site is near a commissure of an anterior leaflet of the tricuspid valve and a posterior leaflet of the tricuspid valve, and wherein penetrating the first end of the wire through the tissue at the first cardiovascular site comprises penetrating the first end of the wire through tissue near the commissure of the anterior leaflet and the posterior leaflet.

14. A method, comprising:

transluminally penetrating a first end of a wire through a tricuspid valve at a first cardiovascular site of a subject;

transluminally advancing a capture device into the subject;

using the capture device, capturing the first end of the wire and pulling the first end of the wire away from the first cardiovascular site;

from the first end of the wire, tracking a first anchor along the wire, and subsequently anchoring the first anchor to the tissue at the first cardiovascular site;

anchoring a second anchor to tissue at a second cardiovascular site of the subject; and

subsequently, drawing together the first cardiovascular site and the second cardiovascular site by applying tension between the first anchor and the second anchor.

15. A method, comprising:

positioning a first end of a wire at a first cardiovascular site of a subject facilitated by a radiopaque member positioned within a blood vessel adjacent to the first cardiovascular site;

transluminally penetrating the first end of the wire through tissue at the first cardiovascular site;

transluminally advancing a capture device into the subject;

using the capture device, capturing the first end of the wire and pulling the first end of the wire away from the first cardiovascular site;

from the first end of the wire, tracking a first anchor along the wire, and subsequently anchoring the first anchor to the tissue at the first cardiovascular site;

anchoring a second anchor to tissue at a second cardiovascular site of the subject; and

subsequently, drawing together the first cardiovascular site and the second cardiovascular site by applying tension between the first anchor and the second anchor.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2025
From: GROOTHUIS, ADAM; CAHALANE, STEVEN D.; MORRILL, RICHARD J.; ALEXANDER, JOHN
To: MITRALIGN, INC.
Reel/Frame 070384/0899 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2025
From: MITRALIGN, INC.
To: EDWARDS LIFESCIENCES CORPORATION
Reel/Frame 070384/0981 →
Continuity (6)
Continuation 17171529 · Feb 9, 2021
Continuation 16184615 · Nov 8, 2018
Continuation 15172972 · Jun 3, 2016
Division 14190732 · Feb 26, 2014
Provisional Application 61769738 · Feb 26, 2013
Related Publication 20240000448A1 · Jan 4, 2024
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