Granted Patent B2

US 12,427,091 · App. 17/423,857 · Granted Sep 30, 2025

Inventor: Niv Ben Shalom (Netanya, IL)

Assignee: West Pharma. Services IL, Ltd.

A61J1/2089A61J1/1406A61J1/1412A61J1/1481A61J1/201A61J1/2058A61J1/2072A61J1/2096

Abstract

Claims (37)

1. A liquid transfer device for use with an intravenous (IV) bottle, an additive transfer device, and an infusion set with an IV spike for intravenous administration of infusion liquid to a patient, the IV bottle containing an infusion liquid and having a closed end tapering towards an open IV bottle neck, an IV bottle crown mounted on the IV bottle neck, and an IV bottle stopper for sealing the IV bottle, the additive transfer device having a male connector, and the liquid transfer device having a longitudinal centerline and comprising:

a vial adapter having:

a top portion extending transverse to the longitudinal centerline and having a top surface and a bottom surface,

a skirt having a top surface, downwardly depending from the top portion, and being configured to telescopically snap fit under a flange of the IV bottle crown,

the top portion having an internal chamber, the internal chamber extending between the bottom surface of the top portion and the top surface of the skirt in a plane transverse to the longitudinal centerline,

a cannula configured to puncture the IV bottle stopper for fluid communication with the IV bottle upon mounting on the IV bottle crown, the cannula having a tip portion with an opening, such that when the cannula is inserted into the IV bottle stopper, the tip portion is the only portion of the cannula exposed to the infusion liquid of the IV bottle, wherein the cannula includes a vent lumen, the top portion includes at least one vent through the top surface of the top portion, the at least one vent being in fluid communication with the internal chamber and the vent lumen,

an upright nipple on the top surface of the top portion oppositely directed with respect to the cannula, the upright nipple having a first nipple section with a first nipple section lumen in fluid communication with a cannula liquid lumen of the cannula, and the upright nipple having a second nipple section with a second nipple section lumen in fluid communication with the cannula liquid lumen, the first nipple section and the second nipple section being angularly offset from one another;

an IV port extending from the first nipple section and including a sealing membrane comprising a material puncturable by the IV spike of the infusion set, the IV port including a fixed portion having a first pair of opposing tabs and a removable portion having a second pair of opposing tabs, wherein the sealing membrane is at a junction of the fixed portion and the removeable portion, and the removable portion is configured to be twisted off the fixed portion to expose the sealing membrane without leading to flow communication beyond the sealing membrane; and

a needleless self-sealing port extending from the second nipple section, the needleless self-sealing port configured to couple with the male connector of the additive transfer device.

2. The liquid transfer device of claim 1 , wherein the flange is configured to serve as a stop for the IV bottle crown.

3. The liquid transfer device of claim 1 , wherein the upright nipple is Y-shaped.

4. The liquid transfer device of claim 1 , wherein the male connector of the additive transfer device is a male Luer lock connector.

5. The liquid transfer device of claim 1 , wherein the additive transfer device comprises a syringe containing a liquid medicament.

6. The liquid transfer device of claim 1 , wherein the additive transfer device comprises a vial containing at least one of a liquid or solid medicament.

7. The liquid transfer device of claim 1 , wherein a diameter of the flange of the IV bottle crown is greater than a diameter of the open IV bottle neck.

8. The liquid transfer device of claim 1 , wherein the cannula has a length that is substantially similar to a height of the IV bottle stopper.

9. The liquid transfer device of claim 1 , wherein the cannula has a length longer than a height of the IV bottle stopper.

10. The liquid transfer device of claim 1 , wherein the cannula liquid lumen extends along the longitudinal centerline, and the vent lumen is offset from the cannula liquid lumen.

11. The liquid transfer device of claim 10 , wherein the opening of the tip portion of the cannula opens to the cannula liquid lumen, and a second opening of the tip portion of the cannula opens to the vent lumen.

12. The liquid transfer device of claim 1 , wherein the vial adapter has an air filter in the internal chamber.

13. A method of preparing a medication for intravenous administration of infusion liquid to a patient using a liquid transfer device, an intravenous (IV) bottle, an additive transfer device and an infusion set with an IV spike, the IV bottle including a closed end tapering towards an open IV bottle neck and containing an infusion liquid, and an IV bottle crown mounted on a collar around the IV bottle neck and having an IV bottle stopper for sealing the IV bottle, and the additive transfer device having a male connector, the method comprising:

coupling the male connector of the additive transfer device to a self-sealing port of the liquid transfer device;

telescopically snap fitting a skirt of a vial adapter of the liquid transfer device under a flange of the IV bottle crown and puncturing the IV bottle stopper with a cannula of the liquid transfer device, the cannula having a cannula liquid lumen and a tip portion with an opening, so that the tip portion is the only portion of the cannula exposed to the infusion liquid of the IV bottle;

mixing an additive contained in the additive transfer device with the infusion liquid;

venting the IV bottle through a vent lumen in the cannula, an internal chamber of a top portion, and at least one vent through a top surface of the top portion, the internal chamber extending between a bottom surface of the top portion and a top surface of the skirt in a plane transverse to a longitudinal centerline of the liquid transfer device;

twisting off a removable portion of an IV port of the liquid transfer device from a fixed portion of the IV port to expose a sealing membrane in the IV port at a junction of the fixed portion and the removeable portion without leading to flow communication beyond the sealing membrane; and

puncturing the sealing membrane of the liquid transfer device with the IV spike of the infusion set.

14. The method of claim 13 , wherein the male connector of the additive transfer device is a male Luer lock connector.

15. The method of claim 13 , wherein the additive transfer device comprises a syringe containing a liquid medicament.

16. The method of claim 13 , wherein the additive transfer device comprises:

a vial containing at least one of a liquid or solid medicament; and

the vial adapter having the male connector.

17. The method of claim 13 , wherein the flange is configured to serve as a stop for the IV bottle crown.

18. The method of claim 13 , further comprising inverting the additive transfer device to drain its contents through the liquid transfer device while minimizing a dead space volume.

19. The method of claim 13 , wherein the cannula liquid lumen extends along the longitudinal centerline, and the vent lumen is offset from the cannula liquid lumen.

20. The method of claim 19 , wherein the opening of the tip portion of the cannula opens to the cannula liquid lumen and a second opening of the tip portion of the cannula opens to the vent lumen.

21. The method of claim 13 , wherein venting the IV bottle is through an air filter in the internal chamber.

Assignments (1)

Continuity (2)

References Cited (400)