IP Library Granted Patent US 12,428,375
Granted Patent B2
US 12,428,375 · App. 18/534,520 · Granted Sep 30, 2025

Compounds and compositions for treating conditions associated with LPA receptor activity

Inventors: Wei Huang (Shanghai, CN); Hui Lei (Shanghai, CN); Zhongmiao Xu (Shanghai, CN); Haizhen Zhang (Shanghai, CN); Qiong Zhang (Shanghai, CN)
Assignee: Lhotse Bio, Inc.
C07D211/66C07C61/39C07C229/18C07C229/28C07D309/14C07D317/54C07D317/58C07D407/12C07C2601/02C07C2601/04C07C2601/08C07C2602/08
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Quick Facts
Patent No.
US 12,428,375
App. No.
18/534,520
Granted
Sep 30, 2025
Kind
B2
Abstract

The present disclosure provides LPA antagonists, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating LPA-associated diseases, disorders, and conditions.

Claims (27)

1. A method for treating a disease, disorder, or condition selected from fibrosis, transplant rejection, cancer, osteoporosis, an inflammatory disorder, idiopathic pulmonary fibrosis (IPF), non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, systemic sclerosis, COVID-19, chronic obstructive pulmonary disease (COPD), neuroinflammation, multiple sclerosis, and Hermansky-Pudlak Syndrome, the method comprising administering to a patient in need thereof an effective amount of a compound selected from:

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the fibrosis is pulmonary fibrosis, liver fibrosis, renal fibrosis, cardiac fibrosis, dermal fibrosis, ocular fibrosis, or pancreatic fibrosis.

3. The method of claim 1 , wherein the cancer is of the bladder, blood, bone, brain, breast, central nervous system, cervix, colon, endometrium, esophagus, gall bladder, genitalia, genitourinary tract, head, kidney, larynx, liver, lung, muscle tissue, neck, oral mucosa, nasal mucosa, ovary, pancreas, prostate, skin, spleen, small intestine, large intestine, stomach, testicle, or thyroid.

4. A method for treating pulmonary fibrosis, the method comprising administering to a patient in need thereof an effective amount of a compound selected from:

or a pharmaceutically acceptable salt thereof.

5. The method of claim 4 , wherein the pulmonary fibrosis is idiopathic pulmonary fibrosis (IPF).

6. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

7. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

8. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

9. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

10. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

11. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

12. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

13. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

14. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

15. The method of claim 5 , the method comprising administering to a patient in need thereof an effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2024
From: HUANG, WEI; LEI, HUI; XU, ZHONGMIAO; ZHANG, HAIZHEN; ZHANG, QIONG
To: SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD.
Reel/Frame 067660/0092 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2024
From: SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD.
To: LHOTSE BIO, INC.
Reel/Frame 067660/0097 →
Priority Claims (3)
WO PCT/CN2022/077844 · Feb 25, 2022 · international
WO PCT/CN2022/094839 · May 25, 2022 · international
WO PCT/CN2022/117690 · Sep 8, 2022 · international
Continuity (3)
Continuation 18322492 · May 23, 2023
Continuation PCTCN2023078288 · Feb 25, 2023
Related Publication 20240376054A1 · Nov 14, 2024
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