IP Library › Granted Patent US 12,435,068

Granted Patent B2

US 12,435,068 · App. 17/287,548 · Granted Oct 7, 2025

Anthelmintic compounds

Inventors: Nils Griebenow (Dormagen, DE); Walter Huebsch (Wuppertal, DE); Hans-Georg Schwarz (Dorsten, DE); Wei Zhuang (Monheim am Rhein, DE); Bernd ALig (Koenigswinter, DE); Adeline Koehler (Langenfeld, DE); Daniel Kulke (Leverkusen, DE); Iring Heisler (Duesseldorf, DE); Thomas Ilg (Monheim, DE)

Assignee: Elanco Animal Health GmbH

C07D405/14 A61P33/10 C07D241/42 C07D249/18 C07D311/58 C07D311/68 C07D405/12 C07D409/12 C07D471/04 C07D495/04

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Quick Facts

Patent No.: US 12,435,068
App. No.: 17/287,548
Granted: Oct 7, 2025
Kind: B2

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Abstract

The present invention relates to novel compounds of general formula (I): with A being A1 or A 2 : and in which T, X, Y, Ro, R 1 , R 10 and R 11 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Claims (328)

1. A compound of formula (I)

wherein:

A is A1 or A2,

o is 0, 1, 2, 3 or 4;

R is selected from the group consisting of hydrogen, halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl, —S(O)—C 1 -C 4 -halogenoalkyl and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

X, Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 ,

X, Y form together a ring member selected from the group consisting of —C(O)—O—, —C(O)—NR 9 —, —S(O)—NR 9 —, —SO 2 —NR 9 — and —SO 2 —O—;

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is selected from the group consisting of hydrogen, cyano, —CHO, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 -alkyl, —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , NH 2 —C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-NH—C 1 -C 4 -alkyl-, (C 1 -C 4 -alkyl) 2 N—C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl-C(O)— having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C(O)—, benzyloxy-C(O)—, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-C(O)—, —SO 2 —C 1 -C 4 -alkyl, and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 —C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R 2 is selected from the group consisting of hydrogen, halogen, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 ;

—NR 12 R 13 ;

—OR 14 ;

—SR 15 , —S(O)R 15 , —SO 2 R 15 ;

C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and

a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 —C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl;

R 3 is selected from the group consisting of hydrogen, halogen or C 1 -C 4 -alkyl;

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl;

R 5 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl;

R 6 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl;

R 7 is selected from the group consisting of hydrogen, —OH, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 8 is selected from the group consisting of hydrogen, —OH, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

or R 7 and R 8 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl;

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 11 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

or R 10 and R 11 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl,

R 12 and R 13 are independently selected from the group consisting of hydrogen, —OH, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH(—C(O)—C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl)(—C(O)—C 1 -C 4 -alkyl), C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C(O)—;

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , —NH—C(O)—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl)(—C(O)—C 1 -C 4 -alkyl), C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and (C 1 -C 4 -alkoxy) 2 P(═O)—;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)-C 1 —C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl, benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

a monocyclic or a bicyclic heterocycle selected from the group of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R 14 is selected from the group consisting of

—NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ;

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alky) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and

a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R 15 is selected from the group consisting of

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 16 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

R 17 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

Q is selected from the group consisting of 6- to 10-membered aryl and 5- to 10-membered heteroaryl, each of which is substituted by 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, SFs, cyano, —CHO, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —OH, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—SO 2 —(C 1 -C 4 -alkyl), —N(SO 2 —[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 _C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —O—(C 1 -C 4 -alkyl), —CH 2 —NH(C 1 -C 4 -alkyl), —CH 2 —N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —S—(C 1 -C 4 -alkyl), —CH 2 —S(O)—(C 1 -C 4 -alkyl), —CH 2 —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -alkyl), —S(O)—(C 1 -C 4 -alkyl), —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C 1 -C 4 -alkyl), —CONH(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -alkyl), —NHCO(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms;

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH, and wherein

when X is O, S or N—R 9 , none of R 7 and R 8 is —OH;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

2. The compound of claim 1 , wherein:

A is A1 or A2,

is 0, 1,2,3 or 4;

X, Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 ,

X, Y form together a ring member selected from the group consisting of —C(O)—O—, —C(O)—NR 9 —, —S(O)—NR 9 —, —SO 2 —NR 9 —and —SO 2 —O—;

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is selected from the group consisting of hydrogen, cyano, —CHO, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 -alkyl, —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , NH 2 —C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-NH—C 1 -C 4 -alkyl-, (C 1 -C 4 -alkyl) 2 N—C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl-C(O)—having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C(O)—, benzyloxy-C(O)—, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-C(O)—, —SO 2 —C 1 -C 4 -alkyl, and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 2 is selected from the group consisting of

hydrogen, halogen, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 ;

—NR 12 R 13 ;

—OR 14 ;

—SR 15 , —S(O)R 15 , —SO 2 R 15 ;

a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl;

R 3 is selected from the group consisting of hydrogen, halogen or C 1 -C 4 -alkyl;

R 4 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 5 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy;

R 6 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 7 is selected from the group consisting of hydrogen, —OH, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 8 is selected from the group consisting of hydrogen, —OH, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 11 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 12 and R 13 are independently selected from the group consisting of hydrogen, —OH, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH(—C(O)—C 1 -C 4 -alkyl), C 1 -C 4 -alkoxy;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 14 is selected from the group consisting of

—NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ;

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 15 is selected from the group consisting of

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 16 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

R 17 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

Q is selected from the group consisting of 6-membered aryl and 5- to 6-membered heteroaryl, each of which is substituted by 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, SF 5 , cyano, —CHO, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —OH, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—SO 2 —(C 1 -C 4 -alkyl), —N(SO 2 —[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —O—(C 1 -C 4 -alkyl), —CH 2 —NH(C 1 -C 4 -alkyl), —CH 2 —N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —S—(C 1 -C 4 -alkyl), —CH 2 —S(O)—(C 1 -C 4 -alkyl), —CH 2 —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -alkyl), —S(O)—(C 1 -C 4 -alkyl), —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C 1 -C 4 -alkyl), —CONH(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -alkyl), —NHCO(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms;

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH, and wherein

when X is O, S or N—R 9 , none of R 7 and R 8 is —OH;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

3. The compound of claim 1 , wherein:

A is A1 or A2;

o is 0, 1 or 2;

R is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy;

X, Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 ;

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy;

R 2 is selected from the group consisting of hydrogen, halogen, cyano, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 ;

—NR 12 R 13 ;

—OR 14 ;

—R 15 , —S(O)R 15 , —SO 2 R 15 ;

—C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C 1 -C 4 -alkoxy-C(O)—, —C(O)—NH 2 , —C(O)—NH(C 1 -C 4 -alkyl), —C(O)—N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl;

R 3 is selected from the group consisting of hydrogen, halogen or C 1 -C 4 -alkyl;

R 5 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy;

R 7 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl;

R 8 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl;

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl;

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy;

R 11 is selected from the group consisting of hydrogen;

R 12 and R 13 are independently selected from the group consisting of hydrogen;

phenyl, benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 14 is selected from the group consisting of

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl;

R 15 is selected from the group consisting of

C 1 -C 4 -alkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano,

C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 16 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

R 17 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy;

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH, and wherein

when X is O, S or N—R 9 , none of R 7 and R 8 is —OH;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

4. The compound of claim 1 , wherein:

A is A1 or A2;

is 0 or 1;

R is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy;

X is selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 ,

Y is CR 7 R 8 ;

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl;

R 2 is selected from the group consisting of

hydrogen, halogen;

—NR 12 R 13 ;

—OR 14 ;

—R 15 , —S(O)R 15 , —SO 2 R 15 ;

C 1 -C 6 -alkyl or C 3 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl;

R 3 is selected from the group consisting of hydrogen, halogen or C 1 -C 4 -alkyl;

R 4 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 5 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 6 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 7 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl;

R 8 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl;

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl;

R 10 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl;

R 11 is selected from the group consisting of hydrogen;

R 12 and R 13 are independently selected from the group consisting of hydrogen;

C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 14 is selected from the group consisting of

R 15 is selected from the group consisting of

C 1 -C 4 -alkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms;

R 16 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R 17 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH, and wherein

when X is O, S or N—R 9 , none of R 7 and R 8 is —OH;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

5. The compound of claim 1 , wherein:

Q is a substituted phenyl ring of formula (Q1)

in which:

Z 1 , Z 2 , Z 3 , Z 4 , and Z 5 are independently selected from the group consisting of hydrogen, halogen, SFs, cyano, —CHO, —C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—SO 2 —(C 1 -C 4 -alkyl), —N(SO 2 —[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —O—(C 1 -C 4 -alkyl), —CH 2 —NH(C 1 -C 4 -alkyl), —CH 2 —N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH 2 —S—(C 1 -C 4 -alkyl), —CH 2 —S(O)—(C 1 -C 4 -alkyl), —CH 2 —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -alkyl), —S(O)—(C 1 -C 4 -alkyl), —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C 1 -C 4 -alkyl), —CONH(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -alkyl), —NHCO(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or

Z 1 and Z 2 form, together with the carbon atoms that they are connected to, a 5-or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6-membered heteroaryl, each of which may be optionally substituted with one or two substituents selected from the group consisting of methyl, fluorine and oxo, and

Z 3 , Z 4 , and Z 5 are independently selected from the group consisting of hydrogen, halogen, SF 5 , cyano, CHO, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C(O)—, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—SO 2 —(C 1 -C 4 -alkyl), —N(SO 2 —[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, —CH 2 —O—(C 1 -C 4 -alkyl), —CH 2 —NH(C 1 -C 4 -alkyl), —CH 2 —N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, —CH 2 —S—(C 1 -C 4 -alkyl), —CH 2 —S(O)—(C 1 -C 4 -alkyl), —CH 2 —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -alkyl), —S(O)—(C 1 -C 4 -alkyl), —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C 1 -C 4 -alkyl), —CONH(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -alkyl), —NHCO(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or

Z 2 and Z 3 form, together with the carbon atoms that they are connected to, a 5-or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6-membered heteroaryl, each of which may be optionally substituted with one or two substituents selected from the group consisting of methyl, fluorine and oxo, and

Z 1 , Z 4 , and Z 5 are independently selected from the group consisting of hydrogen, halogen, SF 5 , cyano, CHO, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—SO 2 —(C 1 -C 4 -alkyl), —N(SO 2 —[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 _C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, —CH 2 —O—(C 1 -C 4 -alkyl), —CH 2 —NH(C 1 -C 4 -alkyl), —CH 2 —N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, —CH 2 —S—(C 1 -C 4 -alkyl), —CH 2 —S(O)—(C 1 -C 4 -alkyl), —CH 2 —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -alkyl), —S(O)—(C 1 -C 4 -alkyl), —SO 2 —(C 1 -C 4 -alkyl), —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C 1 -C 4 -alkyl), —CONH(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -alkyl), —NHCO(C 3 -C 6 -cycloalkyl), —NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or

Q is a pyridine ring of formula (Q2)

in which:

Z 6 , Z 7 , Z 8 and Z 9 are independently selected from the group consisting of hydrogen halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -hydroxyalkyl, NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —NH—CO—C 1 -C 4 -alkyl, and monocyclic heterocycles selected from the group of 4- to 7-membered heterocycloalkyl or 5-membered heteroaryls having at least one nitrogen atom via which the heteroaryl ring is connected to the pyridine ring, each of which is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, —SO 2 —(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or

Q is a pyrimidine ring of formula (Q3)

in which:

Z 10 , Z 11 and Z 12 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , or

Q is a pyridine ring of formula (Q4)

in which:

Z 13 , Z 14 , Z 15 and Z 16 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , or

Q is a pyridine ring of formula (Q5)

in which:

Z 17 , Z 18 , Z 19 and Z 20 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , or

Q is a 5-membered aromatic heterocycle of formula (Q6)

in which:

G 1 -G 4 are independently selected from the group consisting of N, O, S, C—Z 21 and N—Z 22 , wherein not more than one of G 1 -G 4 is O, not more than one of G 1 -G 4 is S, not more than one of G 1 -G 4 is N—Z 22 , and wherein

each Z 21 is independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, and

each Z 22 is independently selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, or

Q is a 5-membered aromatic heterocycle of formula (Q7)

in which:

U 1 —U 4 are independently selected from the group consisting of N and C—Z 23 , wherein not more than three of U 1 —U 4 are N, and wherein

each Z 23 is independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms,

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

6. The compound of claim 1 , wherein:

A is selected from the group consisting of

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is selected from the group consisting of hydrogen or methyl;

R 2 is selected from the group consisting of

hydrogen, chlorine, fluorine, bromine;

—NR 12 R 13 ;

—OR 14 ;

methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclohexyl, each of which is optionally substituted by 1 of 2 substituents independently selected from the group consisting of fluorine, chlorine, cyano, methyl, ethyl, propyl, and isopropyl;

a monocyclic or a bicyclic heterocycle selected from the group consisting of azetidine, pyrrolidine, pyrazolidine, imidazolidine, 1,2,4-triazolidine, piperidine, piperazine, tetrahydropyridine, dihydro-2H-pyrane, tetrahydropyrane, 1,2-oxazolidine, 1,2-oxazine, morpholine, thiomorpholine, 3,4-dihydroisoquinoline, 2,3-dihydro-indole, 1,3-dihydro-isoindole, 3,9-dioxa-7-azabicyclo[3.3.1]nonane, 6-oxa-3-azabicyclo[3.1.1]heptane, 8-oxa-3-azabicyclo[3.2.1]octane, imidazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, 4-oxa-7-azaspiro[2.5]octane, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of fluorine, chlorine, —OH, methyl, trifluoromethyl, methoxymethyl, trifluoromethoxymethyl;

R 3 is selected from the group consisting of hydrogen, chlorine or methyl;

R 4 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, trifluoromethyl, trifluoromethoxy;

R 5 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, trifluoromethyl;

R 6 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, trifluoromethyl, trifluoromethoxy;

R 12 and R 13 are independently selected from the group consisting of

hydrogen and methyl;

R 14 is methyl;

R 16 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, trifluoromethyl;

R 17 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, trifluoromethyl;

Q is a phenyl ring of formula (Q1)

wherein:

Z 1 to Z 5 are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl and trifluoromethyl;

Q is a pyridine ring of formula (Q2)

wherein:

Z 6 to Z 9 are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl and trifluoromethyl;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

7. The compound of claim 1 , wherein:

Q is a phenyl ring of formula (Q1)

wherein:

Z 1 , Z 3 and Z 5 are independently selected from the group consisting of hydrogen, fluorine and chlorine;

Z 2 and Z 4 are independently selected from the group consisting of hydrogen, fluorine, chlorine and trifluoromethyl;

Q is a pyridine ring of formula (Q2)

wherein:

Z 6 to Z 9 are independently selected from the group consisting of hydrogen, fluorine and chlorine; and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof, and/or a mixture thereof.

8. The compound of claim 1 , wherein:

A is selected from the group consisting of

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

9. The compound of claim 1 , wherein:

A is selected from the group consisting of

T is selected from the group consisting of T 1 , T 2 , T 3 , T 4 , T 5 , T 6 , T 7 , T 8a , and T 8b :

L is selected from the group consisting of O and NR 9 ;

M is selected from the group consisting of C═O and CR 7 R 8 ;

U is selected from the group consisting of CR 7 and N;

V is selected from the group consisting of CR 7 and N;

R 1 is hydrogen;

R 2 is selected from the group consisting of hydrogen, chlorine, —NR 12 R 13 , —OR 14 ; methyl, isopropyl, and morpholine;

R 3 is hydrogen or methyl;

R 4 is hydrogen or fluorine;

R 5 is hydrogen or methyl;

R 6 is hydrogen or fluorine;

R 12 and R 13 are independently selected from the group consisting of hydrogen and methyl;

R 14 is methyl;

R 16 is methyl or isopropyl;

R 17 is methyl;

Q is a phenyl ring of formula (Q1)

wherein:

Z 1 , Z 3 and Z 5 are independently selected from the group consisting of hydrogen, fluorine and chlorine;

Z 2 and Z 4 are independently selected from the group consisting of hydrogen, fluorine, chlorine and trifluoromethyl;

Q is a pyridine ring of formula (Q2)

wherein:

Z 6 to Z 9 are independently selected from the group consisting of hydrogen and chlorine;

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

10. The compound of claim 1 , wherein:

A is selected from the group consisting of

and/or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and/or a salt thereof,

and/or a mixture thereof.

11. A method of preparing a compound of claim 1 , said method comprising allowing an intermediate compound of formula Int-I-T1, Int-I-T2, Int-I-T3, Int-I-T4, Int-I-T5, Int-I-T6, Int-I-T7, Int-I-T8a, or Int-I-T8b:

wherein L, M, U, V, A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined for the compound of claim 1 , and wherein Hal is halogen,

to react with a compound of formula 1H

Q-B(OR) 2 1H,

wherein Q is as defined for the compound of claim 1 , and

wherein each R may be individually H or Me or both R are pinacolate,

thereby giving a compound of formula (I):

wherein T, L, M, U, V, A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and Q are as defined in claim 1 ,

allowing an intermediate compound of formula Int-II-T1, Int-II-T2, Int-II-T3, Int-II-T4, Int-II-T5, Int-II-T6, Int-II-T7, Int-II-T8a, or Int-II-T8b:

to react with a compound of formula 1V:

thereby giving a compound of formula (I):

12. A pharmaceutical composition comprising a compound of claim 1 and one or more pharmaceutically acceptable excipients.

13. A method for controlling helminth infection in humans and/or animals comprising administering an anthelminthically effective amount of at least one compound of claim 1 or a pharmaceutical composition thereof to a human or an animal in need thereof.

14. The method of claim 11 , wherein Hal is selected from the group consisting of chlorine, bromine, and iodine.

Assignments (3)

CHANGE OF NAME Recorded Nov 4, 2024

From: BAYER ANIMAL HEALTH GMBH

To: ELANCO ANIMAL HEALTH GMBH

Reel/Frame 069300/0663 →

CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICANT ADDRESS PREVIOUSLY RECORDED ON REEL 056414 FRAME 0782. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 28, 2021

From: GRIEBENOW, NILS; HUEBSCH, WALTER; SCHWARZ, HANS-GEORG; ZHUANG, WEI; ALIG, BERND; KOEHLER, ADELINE; KULKE, DANIEL; HEISLER, IRING; ILG, THOMAS

To: BAYER ANIMAL HEALTH GMBH

Reel/Frame 057521/0331 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2021

From: GRIEBENOW, NILS; HUEBSCH, WALTER; SCHWARZ, HANS-GEORG; ZHUANG, WEI; ALIG, BERND; KOEHLER, ADELINE; KULKE, DANIEL; HEISLER, IRING; ILG, THOMAS

To: BAYER ANIMAL HEALTH GMBH

Reel/Frame 056414/0782 →

Priority Claims (1)

EP 18202419 · Oct 24, 2018 · regional

Continuity (1)

Related Publication 20210380566A1 · Dec 9, 2021

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