IP Library › Granted Patent US 12,440,531
Granted Patent B2
US 12,440,531 · App. 17/602,052 · Granted Oct 14, 2025

Composition for use in improving endothelial function by enhancing flow mediated dilation

Inventors: Lucas Actis Goretta (Singapore, SG); Rachid Bel-Rhlid (Savigny, CH)
Assignee: Societe des Produits Nestle S.A.
A61K36/74A23L33/105A61P3/10A61K2236/10A61K2236/51
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Quick Facts
Patent No.
US 12,440,531
App. No.
17/602,052
Granted
Oct 14, 2025
Kind
B2
Abstract

The present invention relates to a composition comprising esterase treated decaffeinated green coffee extract (HDGCE) for use in a method of improving cardiovascular endpoints such as endothelial function by enhancing flow mediated dilation in a subject, wherein the subject is administered an effective dose of HDGCE with an amount of 100-400 mg/day.

Claims (12)

1. A method for improving cardiovascular flow and reducing the risk of cardiovascular diseases in healthy subjects as measured by changes in measured flow mediated dilation (FMD) in a subject, wherein the subject is administered an effective dose of a composition comprising esterase treated decaffeinated green coffee extract (HDGCE) in an amount of 100-400 mg/day.

2. The method according to claim 1 , wherein the composition is in the form of a functional food product.

3. The method according to claim 1 , wherein the composition comprises a weight ratio of caffeic acid:ferulic acid of at least 2:1.

4. The method according to claim 3 , wherein the composition has a weight ratio of caffeic acid:ferulic acid ranging from 3:1 to 10:1.

5. The method according to claim 1 , wherein the composition has a total content of caffeic acid and ferulic acid between 30 and 80 mg and the composition is a heat-treated composition.

6. The method according to claim 1 , wherein the composition has a total content of caffeic acid and ferulic acid of between 35 and 60 mg and the composition is a heat-treated composition.

7. The method according to claim 1 , wherein the composition is a liquid beverage composition.

8. The method according to claim 1 , wherein the subject, in addition to the administration of HDGCE is further complemented with a meal of at least 200 kcal.

9. The method according to claim 1 , wherein the subject is human.

10. The method according to claim 1 , wherein the cardiovascular disease is endothelial dysfunction.

11. The method according to claim 1 , wherein the composition is in the form of a powder.

12. The method according to claim 1 , wherein the composition is in the form of a snack.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2025
From: ACTIS GORETTA, LUCAS; BEL-RHLID, RACHID
To: NESTEC S.A.
Reel/Frame 072081/0658 →
MERGER Recorded Aug 21, 2025
From: NESTEC S.A.
To: SOCIETE DES PRODUITS NESTLE S.A.
Reel/Frame 072557/0487 →
Priority Claims (1)
EP 19168455 · Apr 10, 2019 · regional
Continuity (1)
Related Publication 20220193172A1 · Jun 23, 2022
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