Macrocyclic ligands with pendant chelating moieties and complexes thereof
The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
1. A compound according to the formula:
wherein
L 1a is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted biaryl, substituted or unsubstituted heteroaryl, and a substituted or unsubstituted polycyclic ring system; and
L x1 and L x6 are independently selected from H, a linker to a reactive functional group, and a linker to a targeting moiety.
2. The compound according to claim 1 , wherein L 1a is selected from:
wherein
n is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
each R and R 1a is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, a reactive functional group and a modifying moiety; and
X is O, S, or CH 2 .
3. The compound according to claim 2 , wherein L 1a has the structure:
4. The compound according to claim 3 , wherein L 1a has the structure:
5. The compound according to claim 1 , wherein at least one of L x1 and L x6 is a linker to a reactive functional group, or a linker to a targeting moiety, wherein the linker to the reactive functional group, or the linker to the targeting moiety has the structure:
-L 11 -F x ,
wherein
L 11 is selected from a bond, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; and
F x is selected from a reactive functional group, a protected functional group, and a targeting moiety.
6. The compound according to claim 5 , wherein the linker to the reactive functional group, or the linker to the targeting moiety has the structure:
wherein
R L is selected from substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl; and
F x is selected from a reactive functional group, a protected functional group, and a targeting moiety.
7. The compound according to claim 6 , wherein at least one of L x1 and L x6 is a linker to a reactive functional group, wherein the linker to the reactive functional group has the structure:
8. The compound according to claim 1 , wherein L x1 has the structure:
9. The compound according to claim 8 , wherein L x6 is H.
10. The compound according to claim 1 , wherein L x6 has the structure:
11. The compound according to claim 10 , wherein L x1 is H.
12. The compound according to claim 1 , wherein:
L x1 is H;
L x6 is H; and
L 1a has the structure:
13. The compound according to claim 1 , wherein:
L x6 is H;
L 1a has the structure;
and
L x1 has the structure:
14. The compound according to claim 1 , wherein:
L x1 is H;
L 1a has the structure
and
L x6 has the structure
15. A complex comprising the compound according to claim 1 and a metal ion complexed therewith.
16. The complex according to claim 15 , wherein the metal ion is selected from Zr(IV), Fe(III), Sc(III), In(III), Eu(III), Ho(III), Lu(III), Y(III), Tb(III), Yb(III), Gd(III), Sm(III), Dy(III), Er(III), Th(IV), Ca(II) and Mg(II).
17. The complex according to claim 15 , wherein the metal ion is Eu(III).
18. The complex according to claim 15 , wherein the metal ion is Ca(II).
19. The complex according to claim 15 , wherein the metal ion is Lu(III).
20. The complex according to claim 15 , wherein the metal ion is Zr(IV).