Compositions and methods for increasing muscle mass and oxidative metabolism
Compositions and methods of use for a compound having a chemical structure of Formula (I) and/or Formula (VII), or a pharmaceutically y acceptable salt or solvate thereof, to increase muscle mass, muscle oxidative capacity, and muscle function and to treat muscular dystrophy, in particular limb girdle muscular dystrophy type 2A/R1/D1 are disclosed.
1. A method of treating muscular dystrophy in a subject, the method comprising administering to the subject an effective amount of a compound having a chemical structure of
or a pharmaceutically acceptable salt or solvate thereof to treat the muscular dystrophy.
2. The method of claim 1 , wherein the compound is administered with a pharmaceutically acceptable carrier.
3. The method of claim 1 , wherein the type of muscular dystrophy is limb girdle muscular dystrophy.
4. The method of claim 1 , wherein the type of muscular dystrophy is limb girdle muscular dystrophy type 2A.
5. The method of claim 1 , wherein treating the muscular dystrophy increases expression of at least one gene selected from the group consisting of myosin light chain-2, Myosin-XVIIIb, Myomesin 3, Lipoprotein lipase, Patatin-Like Phospholipase Domain Containing 2, and Sarcomeric Mitochondrial Creatine Kinase in a subject.