IP Library › Granted Patent US 12,447,126
Granted Patent B2
US 12,447,126 · App. 18/074,996 · Granted Oct 21, 2025

Cerium oxide nanoparticle compositions and methods

Inventors: Sudipta Seal (Oviedo, FL); Swetha Barkam (Orlando, FL); Amitava Adhikary (Rochester, MI)
Assignee: University of Central Florida Research Foundation, Inc.
A61K9/14A61K9/51A61K33/244C01F17/235A61K9/5115A61K9/5192B82Y5/00B82Y30/00B82Y40/00C01P2002/01C01P2002/84C01P2002/85C01P2002/86C01P2004/62C01P2004/64
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Quick Facts
Patent No.
US 12,447,126
App. No.
18/074,996
Granted
Oct 21, 2025
Kind
B2
Abstract

Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO 3 − and Cl − ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Claims (4)

1. A method for synthesizing a cerium nanoparticle composition comprising reducing a cerium precursor salt having a chloride anion to form cerium nanoparticles (CNPs) having a size range of 1 nm to 20 nm; and mixing the CNPs with a solution comprising at least 0.03 mM chloride anions, or optionally 0.03 mM to 30 mM chloride anions; wherein the CNPs have a predominant 4+ surface charge and exhibit SOD mimetic activity.

2. A composition synthesized using the method of claim 1 .

3. A method of modulating surface chemistry and antioxidant capacity of cerium oxide nanoparticles, the method comprising synthesizing cerium oxide nanoparticles (CNPs) to produce a CNP composition, wherein the CNPs have a size range of 1 nm to 20 nm; and increasing a concentration of chloride anion in the CNP composition to at least 0.03 mM, or optionally 0.03 mM to 30 mM, wherein the CNPs have a predominant 4+ surface charge and exhibit SOD mimetic activity.

4. The method of claim 1 , wherein reducing comprises mixing cerium precursor salt in water in the presence of hydrogen peroxide.

Assignments (2)
LICENSE Recorded Feb 11, 2026
From: UNIVERSITY OF CENTRAL FLORIDA
To: NATIONAL INSTITUTES OF HEALTH
Reel/Frame 073757/0047 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2023
From: SEAL, SUDIPTA; BARKAM, SWETHA
To: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 064183/0976 →
Continuity (3)
Division 15956468 · Apr 18, 2018
Provisional Application 62486612 · Apr 18, 2017
Related Publication 20230165797A1 · Jun 1, 2023
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