Autoinjector
An autoinjector includes a case, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case, a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier, and a trigger button operably coupled to the carrier. The case includes a rib. The needle shroud is movable between a first extended position, a retracted position, and a locked second extended position. The carrier is adapted to hold a medicament container and movable from a first axial position to a second axial position relative to the case. The carrier abuts the rib in the first axial position and the needle shroud is in the first extended position and disengages the rib when the needle shroud is in the retracted position and the trigger button is pressed to advance the carrier to the second axial position.
1. An auto-injector comprising:
a case comprising a transparent portion for allowing a medicament within a syringe to be viewed from an exterior of the case when the syringe containing the medicament is disposed in the case;
a cap removably attached to a distal end of the case, the cap configured to engage a protective needle sheath covering a needle of the syringe when the syringe is in the auto-injector such that the protective needle sheath is removed from the needle of the syringe when the cap is removed from the case, the auto-injector being configured to hold the syringe stationary in the case as the cap is removed from the case;
a first part disposed at an axial end of the case, the first part configured to move relative to the case from (i) a first position in which an axial end of the first part is a first distance from the axial end of the case to (ii) a second position in which the axial end of the first part is a second distance from the axial end of the case, the second distance being less than the first distance, the auto-injector being configured such that moving the first part from the first position to the second position allows two beams to deflect in a radially inward direction for allowing needle insertion and medicament delivery to occur;
a syringe carrier disposed in the case, the syringe carrier configured to hold the syringe;
a plunger disposed in the case, the plunger configured to be releasably held in a proximal position within the case, the case configured to allow a portion of the plunger to be viewed from the exterior of the case through the transparent portion of the case;
a compression drive spring disposed in the case with (i) a distal end of the compression drive spring in direct engagement with the plunger for biasing the plunger in a distal direction and (ii) a proximal end of the compression drive spring being held in a fixed axial location as the plunger moves in the distal direction relative to the syringe carrier;
a cylindrical collar configured to rotate relative to the case about a longitudinal axis of the case when the first part is in the second position; and
a second spring disposed in the case with a distal end of the second spring in direct engagement with the cylindrical collar, wherein a diameter of the second spring is larger than a diameter of the compression drive spring,
wherein the auto-injector is configured such that an audible feedback or a tactile feedback is generated to indicate a status of the auto-injector after the cylindrical collar has rotated relative to the case.
2. The auto-injector of claim 1 , wherein the auto-injector is configured such that during needle insertion the syringe carrier holding the syringe moves in the distal direction relative to the case until the syringe carrier contacts a front stop at which the needle of the syringe is or can be injected into an injection site.
3. The auto-injector of claim 2 , wherein the auto-injector is configured such that during medicament delivery the syringe carrier is in contact with the front stop.
4. The auto-injector of claim 3 , wherein the auto-injector is configured such that during medicament delivery the plunger moves relative to the syringe carrier in the distal direction to displace a stopper within the syringe to dispense the medicament from the syringe through the needle for injection into the injection site.
5. The auto-injector of claim 3 , wherein the case comprises the front stop.
6. The auto-injector of claim 1 , wherein the two beams extend in a direction of the longitudinal axis of the case.
7. The auto-injector of claim 6 , wherein respective axial ends of the two beams are oriented towards the axial end of the case and are proximal to a proximal flange of the syringe during use of the auto-injector.
8. The auto-injector of claim 7 , wherein the auto-injector is configured such that an axial portion of the first part is configured to directly engage and deflect the two beams in the radially inward direction.
9. The auto-injector of claim 1 , wherein the auto-injector is configured to limit a movement of the first part relative to the case after the cylindrical collar has rotated relative to the case.
10. The auto-injector of claim 1 , comprising the syringe containing the medicament, wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.
11. An auto-injector comprising:
a case comprising a transparent portion for allowing a medicament within a syringe to be viewed from an exterior of the case when the syringe containing the medicament is disposed in the case;
a first part disposed at an axial end of the case, the first part configured to move relative to the case from (i) a first position in which an axial end of the first part is a first distance from the axial end of the case to (ii) a second position in which the axial end of the first part is a second distance from the axial end of the case, the second distance being less than the first distance, the auto-injector being configured such that moving the first part from the first position to the second position allows two beams to deflect in a radially inward direction for allowing needle insertion and medicament delivery to occur;
a syringe carrier disposed in the case, the syringe carrier configured to hold the syringe;
a plunger disposed in the case, the plunger configured to be releasably held in a proximal position within the case, the case configured to allow a portion of the plunger to be viewed from the exterior of the case through the transparent portion of the case;
a compression drive spring disposed in the case with (i) a distal end of the compression drive spring in direct engagement with the plunger for biasing the plunger in a distal direction and (ii) a proximal end of the compression drive spring being held in a fixed axial location as the plunger moves in the distal direction relative to the syringe carrier;
a cylindrical collar configured to rotate relative to the case about a longitudinal axis of the case when the first part is in the second position; and
a second spring disposed in the case with a distal end of the second spring in direct engagement with the cylindrical collar, wherein a diameter of the second spring is larger than a diameter of the compression drive spring.
12. The auto-injector of claim 11 , comprising a cap configured to be removably attached to a distal end of the case such that a protective needle sheath covering a needle of the syringe is removed from the needle of the syringe when the cap is removed from the case.
13. The auto-injector of claim 12 , wherein the auto-injector is configured to hold the syringe stationary in the case as the cap is removed from the case.
14. The auto-injector of claim 11 , wherein the auto-injector is configured such that an audible feedback or a tactile feedback is generated after the cylindrical collar has rotated relative to the case to indicate a status of the auto-injector.
15. The auto-injector of claim 11 , wherein the auto-injector is configured such that during needle insertion the syringe carrier holding the syringe moves in the distal direction relative to the case until the syringe carrier contacts a stop portion at which a needle of the syringe is or can be injected into an injection site.
16. The auto-injector of claim 15 , wherein the auto-injector is configured such that during medicament delivery (i) the syringe carrier is in contact with the stop portion, and (ii) the plunger moves relative to the syringe carrier in the distal direction to displace a stopper within the syringe to dispense the medicament from the syringe through the needle for injection into the injection site.
17. An auto-injector comprising:
a case comprising a transparent portion for allowing a medicament within a syringe to be viewed from an exterior of the case when the syringe containing the medicament is disposed in the case;
a first part configured to move relative to the case from (i) a first position in which an axial end of the first part is a first distance from an axial end of the case to (ii) a second position in which the axial end of the first part is a second distance from the axial end of the case, the second distance being less than the first distance, the auto-injector being configured such that moving the first part from the first position to the second position allows two beams to deflect in a radially inward direction for allowing needle insertion and medicament delivery to occur;
a syringe carrier disposed in the case, the syringe carrier configured to hold the syringe;
a plunger disposed in the case, the plunger configured to be releasably held in a proximal position within the case, the case configured to allow a portion of the plunger to be viewed from the exterior of the case through the transparent portion of the case;
a compression drive spring disposed in the case with a distal end of the compression drive spring in direct engagement with the plunger for biasing the plunger in a distal direction;
a cylindrical collar configured to rotate relative to the case about a longitudinal axis of the case when the first part is in the second position; and
a second spring disposed in the case with a distal end of the second spring in direct engagement with the cylindrical collar.
18. The auto-injector of claim 17 , wherein the auto-injector is configured such that an audible feedback or a tactile feedback is generated after the cylindrical collar has rotated relative to the case to indicate a status of the auto-injector.
19. The auto-injector of claim 18 , wherein the auto-injector is configured such that the audible feedback or the tactile feedback is generated after the plunger has been released from being held in the proximal position within the case.
20. The auto-injector of claim 17 , wherein a proximal end of the compression drive spring is held in a fixed axial location as the plunger moves in the distal direction relative to the syringe carrier.
21. The auto-injector of claim 17 , wherein a diameter of the second spring is larger than a diameter of the compression drive spring.
22. The auto-injector of claim 17 , comprising the syringe containing the medicament, wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.
23. An auto-injector comprising:
a case comprising a transparent portion for allowing a medicament within a syringe to be viewed from an exterior of the case when the syringe containing the medicament is disposed in the case;
a first part configured to move relative to the case to deflect two beams in a radially inward direction for allowing needle insertion and medicament delivery to occur;
a syringe carrier disposed in the case, the syringe carrier configured to hold the syringe;
a plunger disposed in the case, the plunger configured to be releasably held in a proximal position within the case, the case configured to allow a portion of the plunger to be viewed from the exterior of the case through the transparent portion of the case;
a compression drive spring disposed in the case with a distal end of the compression drive spring in direct engagement with the plunger for biasing the plunger in a distal direction;
a cylindrical collar configured to rotate relative to the case about a longitudinal axis of the case after the first part has moved relative to the case; and
a second spring disposed in the case with a distal end of the second spring in direct engagement with the cylindrical collar.
24. The auto-injector of claim 23 , wherein the auto-injector is configured such that during needle insertion the syringe carrier holding the syringe moves in the distal direction relative to the case until the syringe carrier contacts a stop portion at which a needle of the syringe is or can be injected into an injection site.
25. The auto-injector of claim 24 , wherein the auto-injector is configured such that during medicament delivery (i) the syringe carrier is in contact with the stop portion, and (ii) the plunger moves relative to the syringe carrier in the distal direction to displace a stopper within the syringe to dispense the medicament from the syringe through the needle for injection into the injection site.
26. The auto-injector of claim 23 , wherein the auto-injector is configured such that an audible feedback or a tactile feedback is generated after the cylindrical collar has rotated relative to the case.
27. The auto-injector of claim 23 , comprising a cap configured to be removably attached to a distal end of the case such that a protective needle sheath covering a needle of the syringe is removed from the needle of the syringe when the cap is removed from the case, wherein the auto-injector is configured to hold the syringe stationary in the case as the cap is removed from the case.
28. The auto-injector of claim 23 , wherein the auto-injector is configured such that an axial portion of the first part is configured to directly engage and deflect the two beams in the radially inward direction, and respective axial ends of the two beams are proximal to a proximal flange of the syringe during use of the auto-injector.
29. The auto-injector of claim 23 , comprising the syringe containing the medicament.
30. The auto-injector of claim 29 , wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.