Autoinjector
An autoinjector includes a case, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case, a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier, and a trigger button operably coupled to the carrier. The case includes a rib. The needle shroud is movable between a first extended position, a retracted position, and a locked second extended position. The carrier is adapted to hold a medicament container and movable from a first axial position to a second axial position relative to the case. The carrier abuts the rib in the first axial position and the needle shroud is in the first extended position and disengages the rib when the needle shroud is in the retracted position and the trigger button is pressed to advance the carrier to the second axial position.
1. A method comprising:
viewing a medicament of a syringe from an exterior of a case of an auto-injector while the syringe is inside the case by viewing the medicament through a transparent portion of the case;
removing a cap from a distal end of the case to remove a protective needle sheath covering a needle of the syringe while the auto-injector limits a distal movement of the syringe relative to the case;
after removing the cap from the distal end of the case, moving a first part of the auto-injector relative to the case from (i) a first position in which a depression of a trigger button relative to the case in a distal direction is prevented to (ii) a second position in which the depression of the trigger button relative to the case in the distal direction is allowed;
while the first part is in the second position, depressing the trigger button relative to the case in the distal direction to radially deflect two axially-extending beams to release a plunger of the auto-injector from being held by a proximal part of a carrier of the auto-injector such that the plunger moves in the distal direction relative to the carrier and the case under a distally-directed biasing force of a compression drive spring to displace a stopper within the syringe to dispense the medicament from the syringe through the needle for injection into an injection site, the trigger button being disposed at a proximal end of the auto-injector, a distal part of the carrier surrounding a barrel of the syringe, the two axially-extending beams being disposed between two axial ends of the compression drive spring, and the two axially-extending beams having a ramped portion;
rotating a cylindrical collar relative to the case about a longitudinal axis of the case while a distal end of a second spring is in direct engagement with the cylindrical collar, a diameter of the second spring being larger than a diameter of the compression drive spring;
after rotating the cylindrical collar relative to the case, limiting a re-use of the auto-injector by limiting a movement of the first part relative to the carrier and the case;
generating an audible or tactile feedback to indicate a status of the auto-injector; and
viewing a portion of the plunger from the exterior of the case through the transparent portion of the case.
2. The method of claim 1 , wherein the syringe is disposed within the distal part of the carrier during use of the auto-injector.
3. The method of claim 1 , comprising deflecting the two axially-extending beams in a radially outward direction to release the plunger from being held by the proximal part of the carrier.
4. The method of claim 1 , comprising distally advancing the syringe relative to the carrier and the case before dispensing the medicament from the syringe.
5. The method of claim 1 , comprising releasing a first end of the second spring while a second end of the second spring is grounded to the case, the second spring having a diameter that is larger than the compression drive spring and being external to the plunger.
6. The method of claim 5 , wherein the compression drive spring is within the plunger.
7. The method of claim 1 , comprising viewing a movement of the plunger from the exterior of the case through the transparent portion of the case.
8. The method of claim 1 , wherein the medicament comprises a glucagon-like peptide- 1 (GLP- 1 ) or an analogue or derivative thereof.
9. A method comprising:
removing a cap of an auto-injector from a distal end of a case of the auto-injector to remove a protective needle sheath covering a needle of a syringe while the auto-injector limits a distal movement of the syringe relative to the case;
after removing the cap from the distal end of the case, moving a first part of the auto-injector relative to the case from (i) a first position in which a depression of a trigger button relative to the case in a distal direction is prevented to (ii) a second position in which the depression of the trigger button relative to the case in the distal direction is allowed;
while the first part is in the second position, depressing the trigger button relative to the case in the distal direction to radially deflect two axially-extending beams to release a plunger of the auto-injector from being held by a proximal part of a carrier of the auto-injector such that the plunger moves in the distal direction relative to the carrier and the case under a distally-directed biasing force of a compression drive spring to displace a stopper within the syringe to dispense a medicament from the syringe through the needle for injection into an injection site;
rotating a cylindrical collar relative to the case about a longitudinal axis of the case while a distal end of a second spring is in direct engagement with the cylindrical collar, a diameter of the second spring being larger than a diameter of the compression drive spring;
after rotating the cylindrical collar relative to the case, limiting a re-use of the auto-injector by limiting a movement of the first part relative to the carrier and the case;
generating an audible or tactile feedback to indicate a status of the auto-injector; and
allowing a portion of the plunger to be viewed from an exterior of the case through a transparent portion of the case.
10. The method of claim 9 , comprising deflecting respective ramped portions of the two axially-extending beams to release the plunger from being held by the proximal part of the carrier.
11. The method of claim 9 , wherein a distal part of the carrier surrounds a barrel of the syringe, and the two axially-extending beams are proximal to the syringe.
12. The method of claim 9 , comprising deflecting the two axially-extending beams in a radially outward direction to release the plunger from being held by the proximal part of the carrier.
13. The method of claim 9 , comprising distally advancing the syringe relative to the carrier and the case before dispensing the medicament from the syringe.
14. The method of claim 13 , comprising releasing a first end of the second spring while a second end of the second spring is grounded to the case, the second spring having a diameter that is larger than the compression drive spring and being external to the plunger.
15. The method of claim 9 , comprising allowing a movement of the plunger to be viewed from the exterior of the case through the transparent portion of the case.
16. The method of claim 9 , wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.
17. A method comprising:
after a cap has been removed from a distal end of a case of an auto-injector, moving a first part of the auto-injector relative to the case from (i) a first position in which a depression of a trigger button relative to the case in a distal direction is prevented to (ii) a second position in which the depression of the trigger button relative to the case in the distal direction is allowed, the auto-injector being configured such that a syringe remains stationary within the case as the cap is removed from the distal end of the case;
while the first part is in the second position, depressing the trigger button relative to the case in the distal direction to radially deflect two axially-extending beams to release a plunger of the auto-injector from being held by a proximal part of a carrier of the auto-injector such that the plunger moves in the distal direction relative to the carrier and the case under a distally-directed biasing force of a compression drive spring to displace a stopper within the syringe to dispense a medicament from the syringe through a needle for injection into an injection site;
after dispensing the medicament from the syringe, limiting a re-use of the auto-injector by limiting a movement of the first part relative to the carrier and the case; and
allowing a portion of the plunger to be viewed from an exterior of the case through a transparent portion of the case.
18. The method of claim 17 , comprising allowing a movement of the plunger to be viewed from the exterior of the case through the transparent portion of the case.
19. The method of claim 17 , comprising generating an audible or tactile feedback to indicate a status of the auto-injector.
20. The method of claim 17 , comprising rotating a cylindrical collar relative to the case about a longitudinal axis of the case while a distal end of a second spring is in direct engagement with the cylindrical collar, a diameter of the second spring being larger than a diameter of the compression drive spring.
21. The method of claim 17 , comprising deflecting respective ramped portions of the two axially-extending beams to release the plunger from being held by the proximal part of the carrier, the two axially-extending beams being disposed between two axial ends of the compression drive spring and being proximal to the syringe.
22. The method of claim 21 , comprising deflecting the two axially-extending beams in a radially outward direction to release the plunger from being held by the proximal part of the carrier.
23. The method of claim 17 , wherein the auto-injector comprises a second spring with an axial end grounded to the case, the second spring having a diameter that is larger than the compression drive spring and being external to the plunger.
24. The method of claim 17 , wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.
25. A method comprising:
moving a first part of an auto-injector relative to a case of the auto-injector from (i) a first position in which a depression of a trigger button relative to the case is prevented to (ii) a second position in which the depression of the trigger button relative to the case is allowed, the auto-injector being configured such that a syringe remains stationary within the case as a cap is removed from a distal end of the case;
while the first part is in the second position, depressing the trigger button relative to the case in a distal direction to radially deflect two axially-extending beams to release a plunger of the auto-injector from being held by a proximal part of a carrier of the auto-injector such that the plunger moves in the distal direction relative to the carrier and the case under a distally-directed biasing force of a compression drive spring to displace a stopper within the syringe to dispense a medicament from the syringe through a needle for injection into an injection site;
after dispensing the medicament from the syringe, limiting a movement of the first part relative to the carrier and the case; and
allowing a portion of the plunger to be viewed from an exterior of the case through a transparent portion of the case.
26. The method of claim 25 , wherein limiting the movement of the first part relative to the carrier and the case prevents the auto-injector from being used for a second injection.
27. The method of claim 25 , comprising generating an audible or tactile feedback to indicate a status of the auto-injector after a cylindrical collar has rotated relative to the case, the cylindrical collar being biased by a second spring having a distal end in direct engagement with the cylindrical collar.
28. The method of claim 25 , comprising deflecting respective ramped portions of the two axially-extending beams to release the plunger from being held by the proximal part of the carrier.
29. The method of claim 25 , wherein a distal part of the carrier surrounds a barrel of the syringe while the proximal part of the carrier does not surround the barrel of the syringe.
30. The method of claim 25 , wherein the medicament comprises a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof.