IP Library › Granted Patent US 12,447,321
Granted Patent B2
US 12,447,321 · App. 17/986,526 · Granted Oct 21, 2025

Medicant eluting adjuncts and methods of using medicant eluting adjuncts

Inventors: Jason L. Harris (Lebanon, OH); Frederick E. Shelton, IV (Hillsboro, OH); Michael J. Vendely (Lebanon, OH); Tamara S. Widenhouse (Clarksville, OH)
Assignee: Cilag GmbH International
A61M37/00A61B17/07207A61B17/07292A61B17/1155A61B2017/0046A61B2017/00893A61M2205/04
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Quick Facts
Patent No.
US 12,447,321
App. No.
17/986,526
Granted
Oct 21, 2025
Kind
B2
Abstract

Various exemplary devices and methods are provided for performing surgical procedures. In general, one or more adjuncts can be used in conjunction with surgical instruments. The adjunct(s) can have medicant(s) thereon and/or therein. The medicant(s) can vary depending on the desired effect of the medicant(s) on surrounding tissue. As a non-limiting example, medicant(s) can be provided to influence hemostasis, inflammation, macrophages, and/or fibroblasts. When used in conjunction with a surgical stapler, the adjunct(s) can be disposed between and/or on jaws of the stapler, incorporated into a staple cartridge disposed in the jaws, or otherwise placed in proximity to the staples. When staples are deployed, the adjunct(s) can remain at the treatment site with the staples.

Claims (76)

1. A surgical system, comprising:

an adjunct comprising:

a first bioabsorbable polymer configured to degrade at a first rate in a body of the patient, the first bioabsorbable polymer being located at a first spatial area of the adjunct; and

a second bioabsorbable polymer configured to degrade at a second rate in the body of the patient, the second bioabsorbable polymer being different from the first bioabsorbable polymer, the second rate being different from the first rate, the second bioabsorbable polymer being located at a second spatial area of the adjunct that is different form the first spatial area of the adjunct, the first and second bioabsorbable polymers forming a plurality of coatings; and

a medicant configured to facilitate healing of wounded tissue of a patient having the adjunct stapled thereto, the medicant being retained within a plurality of reservoirs formed within the adjunct, the reservoirs being sealed, pre-degradation, by at least one of the plurality of coatings,

wherein the first and second bioabsorbable polymers are configured to, pre-degradation, prevent the medicant from contacting fluid in the body of the patient,

wherein the medicant is releasable to the wounded tissue in a predetermined spatial aspect defined by the locations of the first and second bioabsorbable polymers, and

wherein degradation of the plurality of coatings is configured to cause the medicant to be released to the wounded tissue differently based on which of the plurality of coatings seals the reservoir.

2. The system of claim 1 , wherein:

the medicant is retained within the adjunct; and

degradation of one or more areas on a surface of the adjunct causes the medicant retained therein to release to the wounded tissue.

3. The system of claim 1 , wherein;

the first bioabsorbable polymer forms an outer layer of a vessel completely encapsulating the medicant within the vessel; and

the vessel is disposed within the adjunct.

4. The system of claim 1 , wherein each of the first and second bioabsorbable polymers is configured to degrade in response to an environmental condition experienced by the polymer in the body of the patient.

5. The system of claim 4 , wherein the environmental condition includes at least one of temperature, pH, moisture, and light.

6. The system of claim 1 , wherein the medicant includes at least one of a tissue matrix degradation inhibitor configured to inhibit matrix metalloproteinase (MMP) and an anti-inflammatory agent.

7. The system of claim 1 , wherein:

the medicant includes a first medicant configured to inhibit inflammation of the tissue;

the medicant includes a second medicant configured to reduce a length of an epithelialization process;

the first bioabsorbable polymer is configured to degrade and thereby release the first medicant to the tissue; and

the second bioabsorbable polymer is configured to degrade and thereby release the second medicant to the tissue after the first medicant has started being released to the tissue.

8. The system of claim 1 , further comprising:

a cartridge body with a plurality of staple cavities on a tissue-facing surface thereof, each staple cavity having a staple disposed therein that is configured to be deployed into tissue; and

an anvil with a plurality of staple forming cavities formed on a tissue-facing surface thereof, wherein the adjunct is disposed on one of the tissue-facing surface of the cartridge body and the tissue-facing surface of the anvil.

9. The system of claim 1 , wherein:

the adjunct has a top side and a bottom side each having a length and a width, the top side being configured to face away from the wounded tissue with the adjunct stapled to the wounded tissue, and the bottom side being configured to face the wounded tissue with the adjunct stapled to the wounded tissue;

the adjunct has opposed lengthwise sides;

the first bioabsorbable polymer coats at least a portion of the top side of the adjunct; and

the second bioabsorbable polymer coats at least a portion of the bottom side of the adjunct.

10. A surgical system, comprising:

a first jaw having a cartridge with a plurality of staple cavities configured to seat staples therein, the staple cavities opening on a tissue-facing surface of the cartridge;

a second jaw having an anvil with a plurality of staple-forming cavities formed on a tissue-facing surface of the anvil, the first and second jaws being configured to clamp tissue therebetween;

an adjunct configured to be stapled to a tissue of a patient with the staples, the adjunct being disposed on one of the tissue-facing surface of the cartridge and the tissue-facing surface of the anvil, the adjunct comprising:

a first bioabsorbable polymer configured to degrade at a first rate in a body of the patient, the first bioabsorbable polymer being located at a first spatial area of the adjunct; and

a second bioabsorbable polymer configured to degrade at a second rate in the body of the patient, the second bioabsorbable polymer being different from the first bioabsorbable polymer, the second rate being different from the first rate, the second bioabsorbable polymer being located at a second spatial area of the adjunct that is different from the first spatial area of the adjunct, the first and second bioabsorbable polymers forming a plurality of coatings; and

a medicant retained within a plurality of reservoirs formed at least partially by one or more of the plurality of coatings, and configured to facilitate healing of the tissue,

wherein the first and second bioabsorbable polymers are configured to, pre-degradation, prevent the medicant from contacting fluid in the body of the patient,

wherein the medicant is releasable to the tissue in a predetermined spatial aspect defined by the locations of the first and second bioabsorbable polymers, and

wherein the reservoirs are each sealed, pre-degradation, by at least one of the plurality of coatings such that degradation of each of the plurality of coatings is configured to cause the medicant to be released to the wounded tissue differently based on which one or more of the plurality of coatings is sealing the reservoir retaining the medicant.

11. The system of claim 10 , wherein:

the first bioabsorbable polymer forms an outer layer of a vessel completely encapsulating the medicant within the vessel; and

the vessel is disposed within the adjunct.

12. The system of claim 10 , wherein each of the first and second bioabsorbable polymers is configured to degrade in response to an environmental condition experienced by the polymer in the body of the patient.

13. The system of claim 10 , wherein:

the medicant includes a first medicant configured to inhibit inflammation of the tissue;

the medicant includes a second medicant configured to reduce a length of an epithelialization process;

the first bioabsorbable polymer is configured to degrade and thereby release the first medicant to the tissue; and

the second bioabsorbable polymer is configured to degrade and thereby release the second medicant to the tissue after the first medicant has started being released to the tissue.

14. A surgical method, comprising:

positioning a surgical stapler at a target location adjacent wounded tissue in a body of a patient, wherein

the surgical stapler includes a cartridge body and an anvil,

the cartridge body has a plurality of staple cavities,

each staple cavity has a surgical staple disposed therein,

an adjunct is releasably retained on one of the cartridge body and the anvil, the adjunct comprising a first bioabsorbable polymer and a second bioabsorbable polymer the first bioabsorbable polymer and the second bioabsorbable polymer forming a plurality of coatings, and

a medicant is retained within a plurality of reservoirs formed within the adjunct and is prevented from contacting fluid in the body of the patient, the reservoirs at least partially formed by the plurality of coatings; and

with the stapler positioned at the target location, actuating the stapler to deploy the staples from the cartridge body and into the tissue, thereby delivering the adjunct to the tissue

wherein, after the adjunct has been delivered to the tissue, the first bioabsorbable polymer located at a first spatial area of the adjunct and the second bioabsorbable polymer located at a second spatial area degrade in the body of the patient in response to an environment condition experienced by the polymer in the body of the patient so as to release the medicant to the wounded tissue according to a predetermined spatial aspect defined by the location of the first and second bioabsorbable polymers,

wherein the reservoirs are each sealed, pre-degradation, by at least one of the plurality of coatings, and

wherein degradation of each of the plurality of coatings causes the medicant to be released to the wounded tissue differently based on which one or more of the plurality of polymer coatings is sealing the reservoir retaining the medicant.

15. The method of claim 14 , wherein:

the first and second bioabsorbable polymers form the adjunct;

the medicant is retained within the adjunct; and

degradation of one or more areas on a surface of the adjunct causes the medicant retained therein to release.

16. The method of claim 14 , wherein:

the first bioabsorbable polymer forms an outer layer of a vessel completely encapsulating the medicant within the vessel; and

the vessel is disposed within the adjunct.

17. A surgical system, comprising:

an adjunct comprising:

a first bioabsorbable polymer configured to degrade at a first rate in a body of a patient, the first bioabsorbable polymer being located at a first spatial area of the adjunct;

a second bioabsorbable polymer configured to degrade at a second rate in the body of the patient, the second bioabsorbable polymer being different from the first bioabsorbable polymer, the second rate being different from the first rate, the second bioabsorbable polymer being located at a second spatial area of the adjunct that is different form the first spatial area of the adjunct;

a top side and a bottom side each having a length and a width, the top side being configured to face away from a wounded tissue with the adjunct stapled to the wounded tissue, and the bottom side being configured to face the wounded tissue with the adjunct stapled to the wounded tissue, the first bioabsorbable polymer coats at least a portion of the top side of the adjunct, and the second bioabsorbable polymer coats at least a portion of the bottom side of the adjunct; and

opposed lengthwise sides; and

a medicant configured to facilitate healing of the wounded tissue of a patient having the adjunct stapled thereto,

wherein the first and second bioabsorbable polymers are configured to, pre-degradation, prevent the medicant from contacting fluid in the body of the patient, and

wherein the medicant is releasable to the wounded tissue in a predetermined spatial aspect defined by the locations of the first and second bioabsorbable polymers.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2025
From: HARRIS, JASON L.; SHELTON, FREDERICK E., IV; VENDELY, MICHAEL J.; WIDENHOUSE, TAMARA S.
To: ETHICON ENDO-SURGERY, LLC
Reel/Frame 072344/0417 →
MERGER Recorded Sep 23, 2025
From: ETHICON ENDO-SURGERY, LLC
To: ETHICON LLC
Reel/Frame 072344/0548 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2025
From: ETHICON LLC
To: CILAG GMBH INTERNATIONAL
Reel/Frame 073007/0237 →
Continuity (4)
Continuation 17183696 · Feb 24, 2021
Continuation 16749125 · Jan 22, 2020
Continuation 14840613 · Aug 31, 2015
Related Publication 20230078145A1 · Mar 16, 2023
References Cited (400)
US 3797494A · Zaffaroni · 1974 [cited by applicant]
US 3993072A · Zaffaroni · 1976 [cited by applicant]
US 4024871A · Stephenson · 1977 [cited by applicant]
US 4512038A · Alexander et al. · 1985 [cited by applicant]
US 4548202A · Duncan · 1985 [cited by applicant]
US 4588400A · Ring et al. · 1986 [cited by applicant]
US 4805823A · Rothfuss · 1989 [cited by applicant]
US 5071417A · Sinofsky · 1991 [cited by applicant]
US 5116357A · Eberbach · 1992 [cited by applicant]
US 5123912A · Kaplan et al. · 1992 [cited by applicant]
US 5282829A · Hermes · 1994 [cited by applicant]
US 5395033A · Byrne et al. · 1995 [cited by applicant]
US 5397324A · Carroll et al. · 1995 [cited by applicant]
US 5441193A · Gravener · 1995 [cited by applicant]
US 5446108A · Jiang · 1995 [cited by applicant]
US 5533521A · Granger · 1996 [cited by applicant]
US 5545208A · Wolff et al. · 1996 [cited by applicant]
US 5607686A · Totakura et al. · 1997 [cited by applicant]
US 5686090A · Schilder et al. · 1997 [cited by applicant]
US 5690675A · Sawyer et al. · 1997 [cited by applicant]
US 5752965A · Francis et al. · 1998 [cited by applicant]
US 5776130A · Buysse et al. · 1998 [cited by applicant]
US 5814057A · Oi et al. · 1998 [cited by applicant]
US 5836970A · Pandit · 1998 [cited by applicant]
US 5980518A · Carr et al. · 1999 [cited by applicant]
US 6162537A · Martin et al. · 2000 [cited by applicant]
US 6241139B1 · Milliman et al. · 2001 [cited by applicant]
US 6248117B1 · Blatter · 2001 [cited by applicant]
US 6325810B1 · Hamilton et al. · 2001 [cited by applicant]
US 6540716B1 · Holm · 2003 [cited by applicant]
US 6551353B1 · Baker et al. · 2003 [cited by applicant]
US 6620166B1 · Wenstrom, Jr. et al. · 2003 [cited by applicant]
US 6656193B2 · Grant et al. · 2003 [cited by applicant]
US 6702850B1 · Byun et al. · 2004 [cited by applicant]
US 6716233B1 · Whitman · 2004 [cited by applicant]
US 6821273B2 · Mollenauer · 2004 [cited by applicant]
US 6927315B1 · Heinecke et al. · 2005 [cited by applicant]
US 7143925B2 · Shelton, IV et al. · 2006 [cited by applicant]
US 7160299B2 · Baily · 2007 [cited by applicant]
US 7238195B2 · Viola · 2007 [cited by applicant]
US 7316693B2 · Viola · 2008 [cited by applicant]
US 7401721B2 · Holsten et al. · 2008 [cited by applicant]
US 7435569B2 · Shah et al. · 2008 [cited by applicant]
US 7464847B2 · Viola et al. · 2008 [cited by applicant]
US 7547312B2 · Bauman et al. · 2009 [cited by applicant]
US 7550152B2 · Pandit et al. · 2009 [cited by applicant]
US 7559453B2 · Heinrich et al. · 2009 [cited by applicant]
US 7601118B2 · Smith et al. · 2009 [cited by applicant]
US 7607557B2 · Shelton, IV et al. · 2009 [cited by applicant]
US 7655288B2 · Bauman et al. · 2010 [cited by applicant]
US 7708180B2 · Murray et al. · 2010 [cited by applicant]
US 7727954B2 · McKay · 2010 [cited by applicant]
US 7776060B2 · Mooradian et al. · 2010 [cited by applicant]
US 7794475B2 · Hess et al. · 2010 [cited by applicant]
US 7845533B2 · Marczyk et al. · 2010 [cited by applicant]
US 7950561B2 · Aranyi · 2011 [cited by applicant]
US 8062330B2 · Prommersberger et al. · 2011 [cited by applicant]
US 8097017B2 · Viola · 2012 [cited by applicant]
US 8118206B2 · Zand et al. · 2012 [cited by applicant]
US 8123766B2 · Bauman et al. · 2012 [cited by applicant]
US 8215531B2 · Shelton, IV et al. · 2012 [cited by applicant]
US 8273369B2 · Moloye-Olabisi et al. · 2012 [cited by applicant]
US 8317070B2 · Hueil et al. · 2012 [cited by applicant]
US 8319211B2 · Sakuma et al. · 2012 [cited by applicant]
US 8329211B2 · Moloye-Olabisi et al. · 2012 [cited by applicant]
US 8365976B2 · Hess et al. · 2013 [cited by applicant]
US 8383147B2 · Shetty et al. · 2013 [cited by applicant]
US 8383156B2 · Zhao · 2013 [cited by applicant]
US 8393514B2 · Shelton, IV et al. · 2013 [cited by applicant]
US 8464925B2 · Hull et al. · 2013 [cited by applicant]
US 8486155B2 · McAlister et al. · 2013 [cited by applicant]
US 8652506B2 · Sikes et al. · 2014 [cited by applicant]
US 8663277B2 · Collier et al. · 2014 [cited by applicant]
US 8672206B2 · Aranyi et al. · 2014 [cited by applicant]
US 8678263B2 · Viola · 2014 [cited by applicant]
US 8679093B2 · Farra · 2014 [cited by applicant]
US 8740872B2 · Dormer et al. · 2014 [cited by applicant]
US 8777004B2 · Shelton, IV et al. · 2014 [cited by applicant]
US 8814025B2 · Miller et al. · 2014 [cited by applicant]
US 8893946B2 · Boudreaux et al. · 2014 [cited by applicant]
US 9084602B2 · Gleiman · 2015 [cited by applicant]
US 9198662B2 · Barton et al. · 2015 [cited by applicant]
US 9204880B2 · Baxter, III et al. · 2015 [cited by applicant]
US 9211120B2 · Scheib et al. · 2015 [cited by applicant]
US 9220500B2 · Swayze et al. · 2015 [cited by applicant]
US 9277919B2 · Timmer et al. · 2016 [cited by applicant]
US 9301752B2 · Mandakolathur Vasudevan et al. · 2016 [cited by applicant]
US 9301753B2 · Aldridge et al. · 2016 [cited by applicant]
US 9320523B2 · Shelton, IV et al. · 2016 [cited by applicant]
US 9332974B2 · Henderson et al. · 2016 [cited by applicant]
US 9351730B2 · Schmid et al. · 2016 [cited by applicant]
US 9364199B2 · Ostapoff et al. · 2016 [cited by applicant]
US 9414838B2 · Shelton, IV et al. · 2016 [cited by applicant]
US 9572574B2 · Shelton, IV et al. · 2017 [cited by applicant]
US 9700311B2 · Shelton, IV et al. · 2017 [cited by applicant]
US 9801630B2 · Harris et al. · 2017 [cited by applicant]
US 9808247B2 · Shelton, IV et al. · 2017 [cited by applicant]
US 9839420B2 · Shelton, IV et al. · 2017 [cited by applicant]
US 9848871B2 · Harris et al. · 2017 [cited by applicant]
US 9937283B2 · Shelton, IV et al. · 2018 [cited by applicant]
US 10076324B2 · Harris et al. · 2018 [cited by applicant]
US 10076329B2 · Shelton, IV et al. · 2018 [cited by applicant]
US 10085745B2 · Dalessandro et al. · 2018 [cited by applicant]
US 10086116B2 · Vendely et al. · 2018 [cited by applicant]
US 10111661B2 · Widenhouse et al. · 2018 [cited by applicant]
US 10123798B2 · Baxter, III et al. · 2018 [cited by applicant]
US 10130738B2 · Shelton, IV et al. · 2018 [cited by applicant]
US 10172973B2 · Vendely et al. · 2019 [cited by applicant]
US 10188389B2 · Vendely et al. · 2019 [cited by applicant]
US 10188390B2 · Harris et al. · 2019 [cited by applicant]
US 10194936B2 · Vendely et al. · 2019 [cited by applicant]
US 10279086B2 · Harris et al. · 2019 [cited by applicant]
US 10285692B2 · Widenhouse et al. · 2019 [cited by applicant]
US 10349938B2 · Widenhouse et al. · 2019 [cited by applicant]
US 10463366B2 · Vendely et al. · 2019 [cited by applicant]
US 10499913B2 · Vendely et al. · 2019 [cited by applicant]
US 10569071B2 · Harris et al. · 2020 [cited by applicant]
US 11020116B2 · Shelton et al. · 2021 [cited by applicant]
US 11129612B2 · Shelton, IV et al. · 2021 [cited by applicant]
US 11826535B2 · Harris et al. · 2023 [cited by applicant]
US 11839733B2 · Harris et al. · 2023 [cited by applicant]
US 20010004459A1 · Barthelemy et al. · 2001 [cited by applicant]
US 20020028243A1 · Masters · 2002 [cited by applicant]
US 20030108511A1 · Sawhney · 2003 [cited by applicant]
US 20030236513A1 · Schwarz et al. · 2003 [cited by applicant]
US 20040043334A1 · Kobayashi et al. · 2004 [cited by applicant]
US 20040254608A1 · Huitema et al. · 2004 [cited by applicant]
US 20050013863A1 · Lim et al. · 2005 [cited by applicant]
US 20050119723A1 · Peacock · 2005 [cited by applicant]
US 20050119725A1 · Wang et al. · 2005 [cited by applicant]
US 20050131390A1 · Heinrich et al. · 2005 [cited by applicant]
US 20050165342A1 · Odland · 2005 [cited by applicant]
US 20050208100A1 · Weber et al. · 2005 [cited by applicant]
US 20050230453A1 · Viola · 2005 [cited by applicant]
US 20050267325A1 · Bouchier et al. · 2005 [cited by applicant]
US 20060025816A1 · Shelton · 2006 [cited by applicant]
US 20060041182A1 · Forbes et al. · 2006 [cited by applicant]
US 20060067976A1 · Ferraro et al. · 2006 [cited by applicant]
US 20060085032A1 · Viola · 2006 [cited by applicant]
US 20060094318A1 · Matsuda et al. · 2006 [cited by applicant]
US 20060108393A1 · Heinrich et al. · 2006 [cited by applicant]
US 20060111738A1 · Wenchell · 2006 [cited by applicant]
US 20060173470A1 · Oray et al. · 2006 [cited by applicant]
US 20060212050A1 · D'Agostino et al. · 2006 [cited by applicant]
US 20060235469A1 · Viola · 2006 [cited by applicant]
US 20070066981A1 · Meagher · 2007 [cited by applicant]
US 20070102453A1 · Morgan et al. · 2007 [cited by applicant]
US 20070112414A1 · Parker et al. · 2007 [cited by applicant]
US 20070123781A1 · Callahan et al. · 2007 [cited by applicant]
US 20070134292A1 · Suokas et al. · 2007 [cited by applicant]
US 20070173787A1 · Huang et al. · 2007 [cited by applicant]
US 20070179528A1 · Soltz et al. · 2007 [cited by applicant]
US 20070190140A1 · Alaux et al. · 2007 [cited by applicant]
US 20070275035A1 · Herman et al. · 2007 [cited by applicant]
US 20080110961A1 · Voegele et al. · 2008 [cited by applicant]
US 20080114334A1 · Voegele · 2008 [cited by applicant]
US 20080114381A1 · Voegele et al. · 2008 [cited by applicant]
US 20080128469A1 · Dalessandro et al. · 2008 [cited by applicant]
US 20080140115A1 · Stopek · 2008 [cited by applicant]
US 20080287878A1 · Tanaka · 2008 [cited by applicant]
US 20080290134A1 · Bettuchi et al. · 2008 [cited by applicant]
US 20090001122A1 · Prommersberger et al. · 2009 [cited by applicant]
US 20090024144A1 · Zeiner et al. · 2009 [cited by applicant]
US 20090062799A1 · Holsten et al. · 2009 [cited by applicant]
US 20090092651A1 · Shah et al. · 2009 [cited by applicant]
US 20090104640A1 · Barron et al. · 2009 [cited by applicant]
US 20090120994A1 · Murray et al. · 2009 [cited by applicant]
US 20090143855A1 · Weber et al. · 2009 [cited by applicant]
US 20090206142A1 · Huitema et al. · 2009 [cited by applicant]
US 20090216104A1 · DeSimone et al. · 2009 [cited by applicant]
US 20090263441A1 · McKay · 2009 [cited by applicant]
US 20090287300A1 · Dave et al. · 2009 [cited by applicant]
US 20100036379A1 · Prakash et al. · 2010 [cited by applicant]
US 20100062606A1 · Morikawa et al. · 2010 [cited by applicant]
US 20100065606A1 · Stopek · 2010 [cited by applicant]
US 20100076489A1 · Stopek et al. · 2010 [cited by applicant]
US 20100087840A1 · Ebersole · 2010 [cited by examiner]
US 20100131050A1 · Zhao · 2010 [cited by applicant]
US 20100137990A1 · Apatsidis et al. · 2010 [cited by applicant]
US 20100147922A1 · Olson · 2010 [cited by applicant]
US 20100179545A1 · Twomey et al. · 2010 [cited by applicant]
US 20100239635A1 · McClain et al. · 2010 [cited by applicant]
US 20100312146A1 · Holsten · 2010 [cited by applicant]
US 20100318108A1 · Datta et al. · 2010 [cited by applicant]
US 20100331880A1 · Stopek · 2010 [cited by applicant]
US 20110066168A1 · Magnusson et al. · 2011 [cited by applicant]
US 20110087279A1 · Shah et al. · 2011 [cited by applicant]
US 20110089219A1 · Hessler · 2011 [cited by applicant]
US 20110106110A1 · McKay · 2011 [cited by applicant]
US 20110112573A1 · Bloom · 2011 [cited by applicant]
US 20110168759A1 · Prommersberger · 2011 [cited by applicant]
US 20110177150A1 · Pathak et al. · 2011 [cited by applicant]
US 20110282446A1 · Schulte et al. · 2011 [cited by applicant]
US 20110319979A1 · Seo et al. · 2011 [cited by applicant]
US 20120010636A1 · Boey et al. · 2012 [cited by applicant]
US 20120080490A1 · Shelton, IV et al. · 2012 [cited by applicant]
US 20120097194A1 · McDaniel et al. · 2012 [cited by applicant]
US 20120125792A1 · Cassivi · 2012 [cited by applicant]
US 20120187179A1 · Gleiman · 2012 [cited by applicant]
US 20120241491A1 · Aldridge et al. · 2012 [cited by applicant]
US 20120241496A1 · Mandakolathur Vasudevan et al. · 2012 [cited by applicant]
US 20120241497A1 · Mandakolathur Vasudevan et al. · 2012 [cited by applicant]
US 20120241499A1 · Baxter, III et al. · 2012 [cited by applicant]
US 20120241503A1 · Baxter, III et al. · 2012 [cited by applicant]
US 20120241505A1 · Alexander, III et al. · 2012 [cited by applicant]
US 20120253298A1 · Henderson et al. · 2012 [cited by applicant]
US 20120253472A1 · Priewe · 2012 [cited by applicant]
US 20120283692A1 · Heffner · 2012 [cited by applicant]
US 20120312860A1 · Ming et al. · 2012 [cited by applicant]
US 20120318842A1 · Anim et al. · 2012 [cited by applicant]
US 20120318844A1 · Shelton, IV et al. · 2012 [cited by applicant]
US 20130037596A1 · Bear et al. · 2013 [cited by applicant]
US 20130062393A1 · Bruewer et al. · 2013 [cited by applicant]
US 20130062394A1 · Smith et al. · 2013 [cited by applicant]
US 20130075447A1 · Weisenburgh, II et al. · 2013 [cited by applicant]
US 20130116341A1 · Askari et al. · 2013 [cited by applicant]
US 20130146643A1 · Schmid et al. · 2013 [cited by applicant]
US 20130149343A1 · Pesnell et al. · 2013 [cited by applicant]
US 20130221065A1 · Aronhalt et al. · 2013 [cited by applicant]
US 20130256365A1 · Shelton, IV et al. · 2013 [cited by applicant]
US 20130256367A1 · Scheib et al. · 2013 [cited by applicant]
US 20130256377A1 · Schmid et al. · 2013 [cited by applicant]
US 20130256380A1 · Schmid et al. · 2013 [cited by applicant]
US 20140005600A1 · Cho et al. · 2014 [cited by applicant]
US 20140048580A1 · Merchant et al. · 2014 [cited by applicant]
US 20140155916A1 · Hodgkinson et al. · 2014 [cited by applicant]
US 20140197224A1 · Penna · 2014 [cited by applicant]
US 20140209658A1 · Skalla et al. · 2014 [cited by applicant]
US 20140217148A1 · Penna · 2014 [cited by applicant]
US 20140276387A1 · Ostapoff et al. · 2014 [cited by applicant]
US 20140358167A1 · Armstrong · 2014 [cited by applicant]
US 20140364941A1 · Edmiston et al. · 2014 [cited by applicant]
US 20150005809A1 · Ayres et al. · 2015 [cited by applicant]
US 20150129634A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150133995A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150133996A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150134076A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150134077A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150196296A1 · Swayze et al. · 2015 [cited by applicant]
US 20150272575A1 · Leimbach et al. · 2015 [cited by applicant]
US 20150313591A1 · Baxter, III et al. · 2015 [cited by applicant]
US 20150351753A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150351754A1 · Harris et al. · 2015 [cited by applicant]
US 20150351757A1 · Harris et al. · 2015 [cited by applicant]
US 20150351758A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150351763A1 · Shelton, IV et al. · 2015 [cited by applicant]
US 20150359529A1 · Ganiban et al. · 2015 [cited by applicant]
US 20150366684A1 · Seo et al. · 2015 [cited by applicant]
US 20150374376A1 · Shelton, IV · 2015 [cited by applicant]
US 20160199063A1 · Mandakolathur Vasudevan et al. · 2016 [cited by applicant]
US 20160206864A1 · Matonick et al. · 2016 [cited by applicant]
US 20160249935A1 · Hewitt et al. · 2016 [cited by applicant]
US 20170055986A1 · Harris et al. · 2017 [cited by applicant]
US 20170119387A1 · Dalessandro et al. · 2017 [cited by applicant]
US 20180200185A1 · Labib et al. · 2018 [cited by applicant]
US 20190321044A1 · Franklin, Sr. · 2019 [cited by applicant]
US 20200155822A1 · Harris et al. · 2020 [cited by applicant]
US 20210196936A1 · Harris et al. · 2021 [cited by applicant]
US 20220087677A1 · Shelton, IV et al. · 2022 [cited by applicant]
CN 101849850A · 2010 [cited by applicant]
CN 102198098A · 2011 [cited by applicant]
EP 0640315A1 · 1995 [cited by applicant]
EP 2008595A2 · 2008 [cited by applicant]
EP 2540311A1 · 2013 [cited by applicant]
EP 2644113A2 · 2013 [cited by applicant]
EP 2644124A1 · 2013 [cited by applicant]
EP 2764824A1 · 2014 [cited by applicant]
EP 2870937A1 · 2015 [cited by applicant]
EP 2910198A2 · 2015 [cited by applicant]
WO WO2006044490A2 · 2006 [cited by applicant]
WO WO2007025293A2 · 2007 [cited by applicant]
WO WO2008140989A2 · 2008 [cited by applicant]
WO WO2010109021A2 · 2010 [cited by applicant]
Abbas, Anastomotic leak: should we continue to accept the risks? Dis Colon Rectum. Jun. 2010;53(6):859-60. [cited by applicant]
Achneck et al., A comprehensive review of topical hemostatic agents. Ann Surg 2010; 251:217-228. [cited by applicant]
Adas et al., Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. Jan. 2011;396(1):115-26. [cited by applicant]
Agren et al., Action of matrix metalloproteinases at restricted sites in colon anastomosis repair: an immunohistochemical and biochemical study. Surgery. Jul. 2006;140(1):72-82. [cited by applicant]
Al Jabri et al., Management and prevention of pelvic adhesions. Sem Rep Med 2011; 29(2):130-137. [cited by applicant]
Anegg et al., Efficiency of fleece-bound sealing (TachoSil) of air leaks in lung surgery: a prospective randomised trial. Eur J Cardiothoracic Surg 2007; 31(2):198-202. [cited by applicant]
Armstrong et al., The effect of three hemostatic agents on early bone healing in an animal model. BMC Surgery 2010; 10:37. [cited by applicant]
Arnold et al., A comparison of burst pressure between buttressed versus non-buttressed staple-lines in an animal model. Obes Surg. Feb. 2005;15(2):164-71. [cited by applicant]
Assalia et al., Staple-line reinforcement with bovine pericardium in laparoscopic sleeve gastrectomy: experimental comparative study in pigs. Obes Surg. Feb. 2007;17(2):222-8. [cited by applicant]
Astafiev GV [All State Laboratory for Surgery Research]. Investigation of processes relating to tissue compression in suturing and stapling apparatus. Surgical Staplers (Chirurgicheskiey Shivayushiye Apparaty). 1967;7 [… [cited by applicant]
Attard et al., The effects of systemic hypoxia on colon anastomotic healing: an animal model. Dis Colon Rectum. Jul. 2005;48(7):1460-70. [cited by applicant]
Aydin et al., FACS, Bariatric Times. 2010;7(3):8-13. [cited by applicant]
Baca et al., Icodextrin and Seprafilm® do not interfere with colonic anastomosis in rats. Eur Surg Res 2007; 39:318-323. [cited by applicant]
Baker et al. The science of stapling and leaks. Obes Surg. 2004; 14:1290-1298. [cited by applicant]
Bartczak et al., Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles. ACS Nano. Jun. 25, 2013;7(6):5628-36. [cited by applicant]
Belda-Sanchis et al., Surgical sealant for preventing air leaks after pulmonary resections in patients with lung cancer. Cochrane Database Syst Rev 2005; 3:CD003051. [cited by applicant]
Bezwada, Controlled Release of Drugs from Novel Absorbable Oligomers and Polymers, White Paper, Bezwada Biomedical, 2008. [cited by applicant]
Bezwada, Functionalized Triclosan for Controlled Release Applications. White Paper, Bezwada Biomedical. 2008. [cited by applicant]
Bezwada, Nitric Oxide and Drug Releasing Hydrolysable Macromers, Oligomers and Polymers, Ch. 11 of Biomaterials, ACS Symposium Series; American Chemical Society: Washington, DC, 2010. [cited by applicant]
Bezwada, Nitric Oxide and Drug Releasing Hydrolysable Macromers, Oligomers and Polymers. White Paper, Bezwada Biomedical. 2009. [cited by applicant]
Bischoff et al., A rheological network model for the continuum anisotropic and viscoelastic behavior of soft tissue. Biomech Model Mechanobiol. Sep. 2004;3(1):56-65. [cited by applicant]
Bischoff, Reduced parameter formulation for incorporating fiber level viscoelasticity into tissue level biomechanical models. Ann Biomed Eng. Jul. 2006;34(7):1164-72. [cited by applicant]
Blouhos et al., The integrity of colonic anastomoses following the intraperitoneal administration of oxaliplatin. Int J Colorectal Dis 2010; 25(7): 835-841. [cited by applicant]
Brady et al., Use of autologous platelet gel in bariatric surgery. Journal of Extra-Corporeal Technology 2006; 38(2):161-164. [cited by applicant]
Broughton G 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. Jun. 2006;117(7 Suppl):12S-34S. [cited by applicant]
Brown et al., Fibroblast Migration in Fibrin Gel Matrices. American Journal of Pathology. 1993;142:273-4. [cited by applicant]
Callery et al., Collagen matrix staple line reinforcement in gastric bypass. Surg Obes Rel Dis 2010. Article in press. [cited by applicant]
D'Andrilli et al., A prospective randomized study to assess the efficacy of a surgical sealant to treat air leaks in lung surgery. Eur J Cardiothoracic Surg 2009; 35:817-821. [cited by applicant]
DeCamp et al., Patient and surgical factors influencing air leak after lung vol. reduction surgery: lessons learned from the National Emphysema Treatment Trial. Ann Thorac Surg. Jul. 2006;82(1):197-206. [cited by applicant]
Deshaies et al., Antiangiogenic agents and late anastomotic complications. J Surg Onc 2010; 101(2):180-183. [cited by applicant]
Dubay et al., Acute wound healing: the biology of acute wound failure. Surg Clin North Am. Jun. 2003;83(3):463-81. [cited by applicant]
Dujovny et al., Minimum vascular occlusive force. J Neurosurg. Nov. 1979;51(5):662-8. [cited by applicant]
Efthimiou et al., Fibrin sealant associated with increased body temperature and leukocytosis after laparoscopic gastric bypass. Surg Obes Rel Dis 2010; 6:46-49. [cited by applicant]
Elariny et al., Tissue thickness of human stomach measured on excised gastric specimens of obese patients. Surg Technol Int. XIV (2005); 14:119-124. [cited by applicant]
Eming et al., “Wound Repair and regeneration: Mechanisms, signaling, and translation,” Science Translational Medicine, vol. 6, No. 265, Dec. 3, 2014. [cited by applicant]
Enestvedt et al., Clinical review: Healing in gastrointestinal anastomoses, part II. Microsurgery. 2006;26(3):137-43. [cited by applicant]
Ersoy et al., Effects of oxaliplatin and 5-Fluorouracil on the healing of colon anastomoses. Surg Today 2009; 39:38-43. [cited by applicant]
European Examination Report for EP 16186419.4 dated May 29, 2018 (5 pages). [cited by applicant]
European Examination Report for EP App. No. 16186387.3 dated Aug. 10, 2018. [cited by applicant]
European Search Report for EP16186385.7 issued Jan. 25, 2017 (6 pages). [cited by applicant]
Fedakar-Senyucel et al., The effects of local and sustained release of fibroblast growth factor on wound healing in esophageal anastomoses. J. Ped Surg 2008; 43 (2):290-295. [cited by applicant]
Fingerhut et al., Use of sealants in pancreatic surgery: Critical appraisal of the literature. Dig Surg 2009; 26:7-14. [cited by applicant]
Frank et al., Clamping the small intestineduring surgery: predicted and measured sealing forces. Proc Inst Mech Eng H. 1995;209(2):111-5. [cited by applicant]
Fullum et al., Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass. Surg Endosc 2009; 23(6):1403-1408. [cited by applicant]
Goto et al., Evaluation of the mechanical strength and patency of functional end-to-end anastomoses. Surg Endosc. Sep. 2007;21(9):1508-11. [cited by applicant]
Gregersen et al., Biomechanics of the gastrointestinal tract. Neurogastroenterol Motil. Dec. 1996;8(4):277-97. [cited by applicant]
Gu et al., Effects of hydration and fixed charge density on fluid transport in charged hydrated soft tissues. Ann Biomed Eng. Nov. 2003;31(10):1162-70. [cited by applicant]
Hardy KJ. Non-suture anastomosis: the historical development. Aust N Z J Surg. Aug. 1990;60(8):625-33. [cited by applicant]
Hendriks et al., Healing of experimental intestinal anastomoses. Parameters for repair. Dis Colon Rectum. Oct. 1990;33(10):891-901. [cited by applicant]
Huh et al., Anastomotic leakage after laparoscopic resection of rectal cancer: The impact of fibrin glue. Am J Surg 2010; 199(4):435-441. [cited by applicant]
Huh et al., Anastomotic leakage after laparoscopic resection of rectal cancer: The impact of fibrin glue. Am J Surg 2010; 1991(4):435-441. [cited by applicant]
International Search Report and Written Opinion for Application No. PCT/US2016/048159 mailed on Nov. 29, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048159 mailed on Nov. 29, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048181 dated Dec. 8, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048267 dated Nov. 24, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048368 dated Dec. 5, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048578 dated Jan. 4, 2017. [cited by applicant]
International Search Report for App. No. PCT/US2016/048583 dated Dec. 2, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048588 dated Nov. 28, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048589 dated Nov. 28, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048594 dated Nov. 8, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048600 dated Nov. 25, 2016. [cited by applicant]
International Search Report for App. No. PCT/US2016/048606 dated Dec. 6, 2016. [cited by applicant]
International Search Report for International App. No. PCT/US2016/048267 dated Nov. 24, 2016. [cited by applicant]
Jonsson et al., Breaking strength of small intestinal anastomoses. Am J Surg. Jun. 1983;145(6):800-3. [cited by applicant]
Kaemmer et al., Erythropoietin (EPO) influences colonic anastomotic healing in a rat model by modulating collagen metabolism. J Surg Res. Oct. 2010;163(2):e67-72. [cited by applicant]
Kanellos et al., Healing of colonic anastomoses after immediate postoperative intraperitoneal administration of oxaliplatin. Int J Colorectal Dis 2008; 23(12):1185-1191. [cited by applicant]
Kennelly et al., Electrical field stimulation promotes anastomotic healing in poorly perfused rat colon. Int J Colorectal Dis 2011; 26:339-344. [cited by applicant]
Kirfel et al., Impaired intestinal wound healing in Fh12-deficient mice is due to disturbed collagen metabolism. Exp Cell Res. Dec. 10, 2008;314(20):3684-91. [cited by applicant]
Kirfel et al., Impaired intestinal wound healing in Fhl2-deficient mice is due to disturbed collagen metabolism. Exp Cell Res. Dec. 10, 2008;314(20):3684-91. [cited by applicant]
Kjaergard HK. Suture support: is it advantageous? Am J Surg. Aug. 2001;182(2 Suppl): 15S-20S. [cited by applicant]
Klein et al., Physiology and pathophysiology of matrix metalloproteases. Amino Acids. Springer, Jul. 18, 2010. [cited by applicant]
Lang et al., Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage afgter standard lobectomy. Eur J Cardiothorac Surg 2004; 25:160-166. [cited by applicant]
Lang et al., Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy. Eur J Cardiothorac Surg 2004; 25:160-166. [cited by applicant]
Lee et al., Efficacy of posterior fixation suture augmented with talc or doxycycline. Graefe's Archive for Clinical and Experimental Ophthamology 2010; 248(9):1287-1292. [cited by applicant]
Lee et al., Using Surgicel to buttress the staple line in lung volume reduction surgery for chronic obstructive pulmonary disease. J Thorac Card Surg 2006; 131(2):495-496. [cited by applicant]
Letowska-Andrzejewicz et al., The use of morphometric and fractal parameters to assess the effects of 5-fluorouracil, interferon and dexamethasone treatment on colonic anastomosis healing: An experimental study in rats.… [cited by applicant]
Li et al., Combination of fibrin glue with growth hormone augments healing of incomplete intestinal anastomoses in a rat model of intra-abdominal sepsis: a dynamic study. J Invest Surg. Sep.-Oct. 2007;20(5):301-6. [cited by applicant]
Li et al., Effect of the combination of fibrin glue and growth hormone on incomplete intestinal anastomoses in a rat model of intra-abdominal sepsis. J Surg Res 2006; 131(1):1110117. [cited by applicant]
Malapert et al., Surgical sealant for the prevention of prolonged air leak after lung resection: Meta-analysis. Ann Thor Surg 2010; 90(6):1779-1785. [cited by applicant]
Martens et al., Postoperative changes in collagen synthesis in between small and large bowel. intestinal anastomoses of the rat: differences Gut 1991;32;1482-1487. [cited by applicant]
McGuireet al., An in vitro assessment of tissue compression damage during circular stapler approximation tests, measuring expulsion of intracellular fluid and force. Proc Inst Mech Eng [H]. 2001;215(6):589-597. [cited by applicant]
Menzies et al., Use of icodextrin 4% solution in the prevention of adhesion formation following general surgery: From the multicentre ARIEL Registry. Ann Royal Coll Surg 2006; 88(4):375-382. [cited by applicant]
Mongardini et al., [The use of Floseal in the prevention and treatment of intra- and post-operative hemorrhage in the surgical treatment of hemorrhoids and colporectocele. Preliminary results]. G Chir. Oct. 2003;24(10):… [cited by applicant]
Munireddy et al., Intra-abdominal healing: gastrointestinal tract and adhesions. Surg Clin North Am. Dec. 2010;90(6):1227-36. [cited by applicant]
Nandakumar et al., Anastomoses of the lower gastrointestinal tract. Nat Rev Gastroenterol Hepatol. Dec. 2009;6(12):709-16. [cited by applicant]
Nandakumar et al., Surgical adhesive increases burst pressure and seals leaks in stapled gastrojejunostomy. Surg Obes Rel Dis 2010; 6:498-502. [cited by applicant]
Nguyen et al., The efficacy of fibrin sealant in prevention of anastomotic leak after laparoscopic gastric bypass. J Surg Res 2004; 122:218-224. [cited by applicant]
Nomori et al., Gelatin-resorcinol-formaldehyde-glutaraldehyde glue-spread stapler prevents air leakage from the lung. Ann Thorac Surg 1997; 63(2):352-355. [cited by applicant]
Nomori et al., The efficacy and side effects of gelatin-resorcinol formaldehyde-glutaraldehyde (GRFG) glue for preventing and sealing pulmonary air leakage. Surgery Today 2000; 30(3):244-248. [cited by applicant]
Okuda et al., “Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro,” Journal of Periodo… [cited by applicant]
Oz et al., Preliminary experience with laser reinforcement of vascular anastomoses. Proceedings of SPIE—The International Society for Optimal Engineering 199; 1422:147-150. [cited by applicant]
Oz et al., Preliminary experience with laser reinforcement of vascular anastomoses. Proceedings of SPIE—The International Society for Optimal Engineering 1991; 1422:147-150. [cited by applicant]
Ozel et al., Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats. World J Gastroenterology 2009; 15(33):4156-4162. [cited by applicant]
Pascual et al., Adipose-derived mesenchymal stem cells in biosutures do not improve healing of experimental colonic anastomoses. Br J Surg 2008; 95(9):1180-1184. [cited by applicant]
Pascual et al., Biosutures improve healing of experimental weak colonic anastomoses. Int J Colorectal Dis 2010; 25(12):1447-1451. [cited by applicant]
Pasternak et al., Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses. Int J Colorectal Dis 2008; 23(3):271-276. [cited by applicant]
Pavlidis et al., The effect of bevacizumab on colon anastomotic healing in rats. Int J Colorectal Dis 2010; 25(12):1465-1473. [cited by applicant]
Rena et al., Air-leak management after upper lobectomy in patients with fused fissure and chronic obstructive pulmonary disease: A pilot trial comparing sealant and standard treatment. Int Cardiovasc Thor Surg 2009; 9(6… [cited by applicant]
Rijcken et al., Insulin-like growth factor 1-coated sutures improve anastomotic healing in an experimental model of colitis. Br J Surg 2010; 97(2): 258-265. [cited by applicant]
Robson et al., Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg. Feb. 2001;38(2):72-140. [cited by applicant]
Rusca et al., Everting versus inverting gastrointestinal anastomoses: bacterial leakage and anastomotic disruption. Ann Surg. May 1969; 169(5):727-35. [cited by applicant]
Sakallioglu et al., Sustained local application of low-dose epidermal growth factor on steroid-inhibited colonic wound healing. J Ped Surg 2004; 39(4):591-595. [cited by applicant]
Sanbeyoulu et al., Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis? Dis col. Rect 2003; 46(4):516-520. [cited by applicant]
Saribeyoglu et al., Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis? Dis col. Rect 2003; 46(4):516-520. [cited by applicant]
Schnriger et al., Prevention of postoperative peritoneal adhesions: A review of the literature. Am J Surg 2011; 201(1):111-121. [cited by applicant]
Search Report for European Patent Application No. EP 16186384.0 dated Feb. 3, 2017. [cited by applicant]
Search Report for European Patent Application No. EP 16186416.0 dated Feb. 3, 2017. [cited by applicant]
Seyda, “Stem Cells and Tissue Engineering” PowerPoint Presentation, Aug. 18, 2009. [cited by applicant]
Shogan et al., Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Trans Med. May 6, 2015;7(286):286ra68. [cited by applicant]
Shogan et al., Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. May 6, 2015;7(286):286ra68. [cited by applicant]
Siemonsma et al., Doxycycline improves wound strength after intestinal anastomosis in the rat. Surgery. Mar. 2003;133(3):268-76. [cited by applicant]
Sileshi et al., Application of energy-based technologies and topical hemostatic agents in the management of surgical hemostasis. Vascular 2010; 18(4):197-204. [cited by applicant]
Spector et al., Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model. Surg Endosc 2011; 25(4):1148-1152. [cited by applicant]
Spector et al., In vitro large diameter bowel anastomosis using a temperature controlled laser tissue soldering system and albumin stent. Lasers in Surgery and Medicine 2009; 41(7):504-508. [cited by applicant]
Stammberger et al., Buttressing the staple line in lung volume reduction surgery: a randomized three-center study. Ann Thorac Surg. Dec. 2000;70(6):1820-5. [cited by applicant]
Subhas et al., Topical gentamicin does not provide any additional anastomotic strength when combined with fibrin glue. Am J Surg 2001; 201 (3):339-343. [cited by applicant]
Suresh et al., Seprafilm slurry does not increase complication rates after laparoscopic colectomy. Surg Endosc. Aug. 2011;25(8):2661-5. [cited by applicant]
Syk et al., Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model. Br J Surg. Feb. 2001;88(2):228-34. [cited by applicant]
Thompson et al., Clinical review: Healing in gastrointestinal anastomoses, part I. Microsurgery. 2006;26(3):131-6. [cited by applicant]
U.S. Appl. No. 14/667,842 entitled “Method of Applying a Buttress to a Surgical Stapler” filed on Mar. 25, 2015. [cited by applicant]
U.S. Appl. No. 14/300,954, entitled “Adjunct Materials and Methods of Using Same in Surgical Methods for Tissue Sealing,” filed on Jun. 10, 2014. [cited by applicant]
U.S. Appl. No. 14/318,996 entitled “Fastener Cartridges Including Extensions Having Different Configurations” filed on Jun. 30, 2014. [cited by applicant]
U.S. Appl. No. 14/498,145 entitled “Method for Creating a Staple Line” filed on Sep. 26, 2014. [cited by applicant]
U.S. Appl. No. 14/667,874 entitled “Malleable Bioabsorbable Polymer Adhesive for Releasably Attaching a Staple Buttress to a Surgical Stapler” filed Mar. 25, 2015. [cited by applicant]
U.S. Appl. No. 14/840,255 entitled “Adjunct Material to Promote Tissue Growth” filed Aug. 31, 2015. [cited by applicant]
U.S. Appl. No. 14/840,386 entitled “Surgical Adjuncts Having Medicants Controllably Releasable Therefrom” filed Aug. 31, 2015. [cited by applicant]