IP Library › Granted Patent US 12,453,631
Granted Patent B2
US 12,453,631 · App. 17/645,690 · Granted Oct 28, 2025

Collapsible-expandable heart valves

Inventor: Brian S. Conklin (Orange, CA)
Assignee: EDWARDS LIFESCIENCES CORPORATION
A61F2/243A61F2/24A61F2/2412A61F2/2415A61F2/2418A61F2/2433A61F2220/0075A61F2230/0054A61F2250/0036A61F2250/006A61F2250/0071
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Quick Facts
Patent No.
US 12,453,631
App. No.
17/645,690
Granted
Oct 28, 2025
Kind
B2
Abstract

A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.

Claims (23)

1 . A prosthetic heart valve for implant at a patient's aortic annulus having a fibrous shelf between an upstream left ventricle and a downstream aorta, comprising:

a collapsible-expandable one-piece frame having a stent portion and a leaflet support portion, the frame being formed of material that permits radial collapse to a collapsed state having a small profile for delivery to the annulus and which enables elastic self-expansion from the collapsed state to an expanded state, the leaflet support portion being positioned along an axis at an outflow end of the frame in series with the stent portion at an inflow end, the leaflet support portion having around a frame periphery a continuous structure formed of elongate members defining three alternating arcuate cusps curved toward the inflow end and three upstanding commissure supports projecting toward the outflow end and terminating in arcuate commissure tips, the leaflet support portion having a cloth covering extending along the cusps and commissure supports, wherein the stent portion comprises a plurality of axially-oriented struts spaced around the frame periphery and connected by a plurality of rows of collapsible-expandable bent struts that allow the stent portion to radially collapse to a compressed configuration for delivery and facilitate expansion of the stent portion so as to engage the inner periphery of the body lumen, wherein three of the axially-oriented struts couple the stent portion to the leaflet support portion, and wherein the axially-oriented struts that couple the stent portion to the leaflet support portion are aligned with and couple directly to the upstanding commissure supports of the leaflet support portion; and

three flexible bioprosthetic leaflets each having an arcuate cusp portion between two commissure portions, each arcuate cusp portion being co-extensive and secured to the cloth covering around one of the leaflet support portion cusps, and each commissure portion having a tab, wherein the tabs of each adjacent leaflet pair are brought together and secured to one of the upstanding commissure supports of the leaflet support portion, and wherein

the stent portion is configured to engage an inner periphery of a body lumen at the aortic annulus implantation site with the commissure supports being cantilevered into the aorta.

2 . The heart valve of claim 1 , wherein the frame material is a superelastic metal.

3 . The heart valve of claim 1 , wherein the frame material is a polymer.

4 . The heart valve of claim 1 , further including a fabric skirt coupled to the stent portion and configured to prevent leakage between the struts.

5 . The heart valve of claim 1 , wherein each adjacent pair of leaflet commissure portions passes radially outward between struts of one of the upstanding commissure supports and is secured to the corresponding axially-oriented strut at that upstanding commissure support.

6 . The heart valve of claim 1 , further including a compressible sealing ring positioned around an inflow end of the leaflet support portion with an undulating shape that tracks along the arcuate cusps of the leaflet support portion.

7 . A prosthetic heart valve for implant at a patient's aortic annulus having a fibrous shelf between an upstream left ventricle and a downstream aorta, comprising:

a collapsible-expandable one-piece frame having a stent portion and a leaflet support portion, the frame being formed of material that permits radial collapse to a collapsed state having a small profile for delivery to the annulus and which enables elastic self-expansion from the collapsed state to an expanded state, the leaflet support portion being positioned along an axis at an outflow end of the frame in series with the stent portion at an inflow end, the leaflet support portion having around a frame periphery a continuous structure formed of elongate members defining three alternating arcuate cusps curved toward the inflow end and three upstanding commissure supports projecting toward the outflow end and terminating in arcuate commissure tips, the leaflet support portion having a cloth covering extending along the cusps and commissure supports; and

three flexible bioprosthetic leaflets each having an arcuate cusp portion between two commissure portions, each arcuate cusp portion being co-extensive and secured to the cloth covering around one of the leaflet support portion cusps, and each commissure portion having a tab, wherein the tabs of each adjacent leaflet pair are brought together and passed radially outward through one of the upstanding commissure supports of the leaflet support portion; and

a collapsible-expandable leaflet support stent having a circumferentially extending base member and three posts extending longitudinally therefrom, each post being located radially outward from one of the commissure supports and the tabs of each adjacent leaflet pair being secured thereto, and wherein

the stent portion is configured to engage an inner periphery of a body lumen at the aortic annulus implantation site with the commissure supports being cantilevered into the aorta.

8 . The heart valve of claim 7 , wherein the frame material is a superelastic metal.

9 . The heart valve of claim 7 , wherein the frame material is a polymer.

10 . The heart valve of claim 7 , wherein the stent portion comprises a plurality of axially-oriented struts spaced around the frame periphery and connected by a plurality of rows of collapsible-expandable bent struts that allow the stent portion to radially collapse to a compressed configuration for delivery and facilitate expansion of the stent portion so as to engage the inner periphery of the body lumen, and wherein three of the axially-oriented struts couple the stent portion to the leaflet support portion.

11 . The heart valve of claim 7 , wherein the stent portion comprises a plurality of axially-oriented struts spaced around the frame periphery and connected by a plurality of rows of collapsible-expandable bent struts that allow the stent portion to radially collapse to a compressed configuration for delivery and facilitate expansion of the stent portion so as to engage the inner periphery of the body lumen, and wherein three of the axially-oriented struts couple the stent portion to the leaflet support portion, and wherein the stent portion couples to the leaflet support portion at connecting segments positioned at approximately the center of each of the cusps of the leaflet support portion.

12 . The heart valve of claim 7 , wherein the stent portion comprises a plurality of axially-oriented struts spaced around the frame periphery and connected by a plurality of rows of collapsible-expandable bent struts that allow the stent portion to radially collapse to a compressed configuration for delivery and facilitate expansion of the stent portion so as to engage the inner periphery of the body lumen, and further including a fabric skirt coupled to the stent portion and configured to prevent leakage between the struts.

13 . The heart valve of claim 7 , further including a compressible sealing ring positioned around an inflow end of the leaflet support portion with an undulating shape that tracks along the arcuate cusps of the leaflet support portion.

14 . The heart valve of claim 13 , wherein the stent portion and the leaflet support portion are separate components not directly connected, and are coupled together with sutures through the sealing ring.

15 . The heart valve of claim 13 , wherein the leaflet support stent and the sealing ring form a subassembly coupled together with a cloth covering.

16 . The heart valve of claim 7 , wherein the leaflet support stent comprises an annular stent frame of a superelastic metal coupled to three polymer commissure tips that form the posts.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2025
From: CONKLIN, BRIAN S.
To: EDWARDS LIFESCIENCES CORPORATION
Reel/Frame 072482/0935 →
Continuity (7)
Continuation 16989826 · Aug 10, 2020
Continuation 15864992 · Jan 8, 2018
Continuation 14466912 · Aug 22, 2014
Division 13237556 · Sep 20, 2011
Provisional Application 61472083 · Apr 5, 2011
Provisional Application 61386833 · Sep 27, 2010
Related Publication 20220110743A1 · Apr 14, 2022
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