IP Library › Granted Patent US 12,455,242
Granted Patent B2
US 12,455,242 · App. 18/626,595 · Granted Oct 28, 2025

Autofluorescence enhanced photothermal infrared spectroscopy

Inventor: Craig Prater (Santa Barbara, CA)
Assignee: PHOTOTHERMAL SPECTROSCOPY CORP.
G01N21/6456G01N21/6486G01N2201/062G01N2201/0636
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Quick Facts
Patent No.
US 12,455,242
App. No.
18/626,595
Granted
Oct 28, 2025
Kind
B2
Abstract

Methods and systems described herein detect autofluorescence of a sample. These methods and systems obviate the need for addition of fluorophores to samples to create IR absorption.

Claims (31)

1. A method for performing infrared imaging of a sample, the method comprising:

illuminating a first region of the sample with an infrared source that generates a modulated infrared beam;

illuminating a second region of the sample at least partially overlapping the first region with a beam of excitation radiation to excite autofluorescent emission;

detecting at least a portion of the autofluorescent emission from the second region by at least one detector as detected autofluorescent emission;

obtaining a first measurement of autofluorescent emission of the second region with a first value of infrared beam energy;

obtaining a second measurement of autofluorescent emission of the second region with a second value of infrared beam energy; and

constructing an output indicative of infrared absorption of the sample using the first and the second measurements of autofluorescent emission.

2. The method of claim 1 , wherein the at least one detector is an array-based detector.

3. The method of claim 1 , wherein the at least one detector is a single-point detector.

4. The method of claim 1 , wherein a source of the beam of excitation radiation is a light emitting diode (LED) source.

5. The method of claim 1 , wherein a source of the beam of excitation radiation is a laser source.

6. The method of claim 1 , wherein the illuminating of the first region and illuminating the second region is performed using a counter-propogating geometry.

7. The method of claim 1 , wherein the illuminating of the first region and illuminating the second region is performed using a co-propogating geometry.

8. The method of claim 7 , wherein the sample is opaque.

9. The method of claim 1 , wherein detecting the detected autofluorescent emission comprises detecting a target class selected from the group consisting of: NAD(P)H bound, NAD(P)H free, fatty acids, vitamins, flavins, proteins, porphyrins, and chlorophyll.

10. The method of claim 1 , wherein constructing the output comprises substantially maximizing transmission of a peak amplitude of an autofluorescent emission spectrum of the sample.

11. An apparatus for performing infrared imaging of a sample,

the apparatus comprising:

an excitation radiation source configured to illuminate a first region of the sample with a beam of excitation radiation to excite autofluorescent emission in the sample;

a modulated infrared source configured to illuminate a second region of the sample at least partially overlapping the first region with a modulated infrared beam to create an infrared illuminated region of the sample;

at least one detector configured to capture at least a portion of the autofluorescent emission from the infrared illuminated region of the sample and obtain a first measurement of autofluorescent emission of the second region with a first value of infrared beam energy and obtain a second measurement of autofluorescent emission of the second region with a second value of infrared beam energy; and

a demodulator configured to construct a signal indicative of infrared absorption of the second region of the sample using the first and second measurements of autofluorescent emission.

12. The apparatus of claim 11 , wherein the at least one detector is an array-based detector.

13. The apparatus of claim 11 , wherein the at least one detector is a single-point detector.

14. The apparatus of claim 11 , wherein the excitation radiation source is a light emitting diode (LED) source.

15. The apparatus of claim 11 , wherein the excitation radiation source is a laser source.

16. The apparatus of claim 11 , wherein the illuminating of the first region and the illuminating of the second region is performed using a counter-propogating geometry.

17. The apparatus of claim 11 , wherein illumination of the first region and the illumination of the second region is performed using a co-propogating geometry.

18. The apparatus of claim 17 , wherein the sample is opaque.

19. The apparatus of claim 11 , further comprising a stage configured to hold the sample.

20. The apparatus of claim 19 , wherein the stage is movable relative to at least one of the beam of infrared illumination and the beam of excitation radiation.

Continuity (2)
Continuation 17937447 · Oct 1, 2022
Related Publication 20240361243A1 · Oct 31, 2024
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